ChemicalBook > CAS DataBase List > 4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE

4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE

Product Name
4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE
CAS No.
5754-34-7
Chemical Name
4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE
Synonyms
2-(2,2-Dimethyl-1,3-dioxolan-4-yl);2,2-dimethyl-1,3-dioxolane-4-ethanol;1,3-Dioxolane-4-ethanol, 2,2-diMethyl-;4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIO&;4-(2-Hydroxyethyl)-2,2-diMethyl-1,3-dioxolaMe;4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE;(RAC)-2-(2,2-DIMETHYL[1,3]DIOXOLANE-4YL)ETHANOL;4-(2-Hydroxyethyl)-2,2-diMethyl-1,3-dioxolane 98%;1,4-Benzenedicarboxylicacid,bis(5-methylethyl)ester;ETHYL 7-(4-CHLOROPHENYL)-4-(3,4-DIMETHOXYPHENYL)-2-METHYL-5-OXO-4,6,7,8-TETRAHYDRO-1H-QUINOLINE-3-CA
CBNumber
CB8754365
Molecular Formula
C7H14O3
Formula Weight
146.18
MOL File
5754-34-7.mol
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4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE Property

Boiling point:
199-200 °C(lit.)
Density 
1.031 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.4400(lit.)
Flash point:
>230 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
14.80±0.10(Predicted)
Appearance
Colorless to light yellow Liquid
InChI
InChI=1S/C7H14O3/c1-7(2)9-5-6(10-7)3-4-8/h6,8H,3-5H2,1-2H3
InChIKey
YYEZYENJAMOWHW-UHFFFAOYSA-N
SMILES
O1CC(CCO)OC1(C)C
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Safety

RIDADR 
NA 1993 / PGIII
WGK Germany 
3
Storage Class
10 - Combustible liquids
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
571466
Product name
4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane
Purity
89%
Packaging
5g
Price
$106.4
Updated
2025/07/31
Sigma-Aldrich
Product number
571466
Product name
4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane
Purity
89%
Packaging
25g
Price
$224
Updated
2025/07/31
TCI Chemical
Product number
D5914
Product name
2-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethan-1-ol
Purity
min. 90.0 %
Packaging
1G
Price
$53
Updated
2025/07/31
TCI Chemical
Product number
D5914
Product name
2-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethan-1-ol
Purity
min. 90.0 %
Packaging
5G
Price
$209
Updated
2025/07/31
TRC
Product number
D481123
Product name
2-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethanol
Packaging
5g
Price
$335
Updated
2021/12/16
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4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE Chemical Properties,Usage,Production

Uses

2-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethanol is used in preparation of cationic lipids and stealth lipids for treating a variety of disorders.

Synthesis

3068-00-6

67-64-1

5754-34-7

GENERAL STEPS: A mixture of 1,2,4-butanetriol (15 g, 141 mmol), acetone (100 mL, 1362 mmol), and p-toluenesulfonic acid monohydrate (700 mg, 3.68 mmol) was stirred for 16 hours at room temperature. Upon completion of the reaction, triethylamine (2 mL, 14.3 mmol) was added to the reaction mixture to neutralize the acidic catalyst and the mixture was subsequently concentrated. The resulting residue was purified by silica gel column chromatography (silica gel, eluting solvent: heptane/ethyl acetate = 1/0 → 1/1-1/3 gradient) to afford 4-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolane (16.55 g, yield: 80.3%) as a colorless oil. 1H-NMR (400 MHz, CDCl3) δ ppm: 1.37 (3H, s), 1.43 (3H, s), 1.79-1.86 (2H, m), 2.18-2.24 (1H, br), 3.60 (1H, dd, J = 7.8 Hz), 3.76-3.86 (2H, m), 4.10 (1H, dd, J = 6.8 Hz), 4.23-4.32 (1H, m).

References

[1] Nucleosides, Nucleotides and Nucleic Acids, 2005, vol. 24, # 10-12, p. 1543 - 1568
[2] European Journal of Organic Chemistry, 2015, vol. 2015, # 27, p. 6075 - 6083
[3] Journal of Organic Chemistry, 1996, vol. 61, # 3, p. 831 - 837
[4] Tetrahedron Letters, 1999, vol. 40, # 2, p. 209 - 212
[5] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 9, p. 1247 - 1250

4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE Preparation Products And Raw materials

Raw materials

Preparation Products

1-METHYLTHYMINE
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4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE Suppliers

Austria 1 China 79 Germany 1 India 1 Switzerland 1 United Kingdom 1 United States 4 Global 88
Nanjing Norris-Pharm Technology Co., Ltd
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View Lastest Price from 4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE manufacturers

Career Henan Chemical Co
Product
4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE 5754-34-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg
Release date
2018-08-13

5754-34-7, 4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANERelated Search:

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  • 4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE
  • (RAC)-2-(2,2-DIMETHYL[1,3]DIOXOLANE-4YL)ETHANOL
  • 4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIO&
  • 2,2-dimethyl-1,3-dioxolane-4-ethanol
  • 1,3-Dioxolane-4-ethanol, 2,2-diMethyl-
  • 4-(2-Hydroxyethyl)-2,2-diMethyl-1,3-dioxolaMe
  • 4-(2-Hydroxyethyl)-2,2-diMethyl-1,3-dioxolane 98%
  • 2-(2,2-Dimethyl-1,3-dioxolan-4-yl)
  • 1,4-Benzenedicarboxylicacid,bis(5-methylethyl)ester
  • ETHYL 7-(4-CHLOROPHENYL)-4-(3,4-DIMETHOXYPHENYL)-2-METHYL-5-OXO-4,6,7,8-TETRAHYDRO-1H-QUINOLINE-3-CA
  • 5754-34-7
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