L-Leucinamide hydrochloride
- Product Name
- L-Leucinamide hydrochloride
- CAS No.
- 10466-61-2
- Chemical Name
- L-Leucinamide hydrochloride
- Synonyms
- H-Leu-NH2Cl;LEU-NH2 HCL;H-LEU-NH2 HCL;L-Leu-NH2.HCl;LEUCINE-NH2 HCL;H-L-LEU-NH2 HCL;L-Leucinamide HCl;L-LEUCINEAMIDE HCL;H-Leu-NH2·HCl ,≥99%;L-Leucinamide hydroc
- CBNumber
- CB8754976
- Molecular Formula
- C6H15ClN2O
- Formula Weight
- 166.65
- MOL File
- 10466-61-2.mol
L-Leucinamide hydrochloride Property
- Melting point:
- 254256°C
- alpha
- 9 º (c=1, H2O)
- refractive index
- 9.8 ° (C=5, H2O)
- storage temp.
- Inert atmosphere,Room Temperature
- Water Solubility
- very faint turbidity in Water
- form
- Powder
- color
- White to off-white
- optical activity
- [α]25/D +10°, c = 5 in H2O
- Sensitive
- Hygroscopic
- BRN
- 4237021
- CAS DataBase Reference
- 10466-61-2(CAS DataBase Reference)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 29241900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H317May cause an allergic skin reaction
H318Causes serious eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P403+P235Store in a well-ventilated place. Keep cool.
N-Bromosuccinimide Price
- Product number
- 286427
- Product name
- L-Leucinamide hydrochloride
- Purity
- 99%
- Packaging
- 5g
- Price
- $128
- Updated
- 2025/07/31
- Product number
- L0094
- Product name
- L-Leucinamide Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $28
- Updated
- 2025/07/31
- Product number
- L0094
- Product name
- L-Leucinamide Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $89
- Updated
- 2025/07/31
- Product number
- 281409
- Product name
- L-Leucine amide hydrochloride
- Packaging
- 10g
- Price
- $353
- Updated
- 2021/12/16
- Product number
- 164678
- Product name
- L-Leucinamide Hydrochloride
- Packaging
- 1g
- Price
- $403
- Updated
- 2021/12/16
L-Leucinamide hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Crystalline
Uses
L-Leucinamide Hydrochloride, is a derivative of Leucine, which is an essential amino acid, and acts as a nutrient signal to stimulate protein synthesis. L-Leucinamide Hydrochloride, is shown to be the potential elicitors of insulin secretion in rats.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
7517-19-3
10466-61-2
The general procedure for the synthesis of L-leucinamide hydrochloride from L-leucine methyl ester hydrochloride is as follows: the synthesis is an improvement on a previously published method. The raw material L-leucine methyl ester hydrochloride can be purchased from Alfa Aesar. L-Leucine methyl ester hydrochloride (1.0 g, 5.5 mmol) and methanol (10 mL) were added to a glass pressure tube, followed by a methanol solution of 7N ammonia (7.9 mL, 55 mmol). The reaction tube was sealed, heated to 50 °C and kept for 2 days. After completion of the reaction, the mixture was concentrated in vacuum. The crude product was suspended in 1,4-dioxane (10 mL) and converted to hydrochloride by addition of 1,4-dioxane solution (1.7 mL, 6.8 mmol) in 4N HCl. Mixing was facilitated by sonication. The solvent and excess HCl were removed using a rotary evaporator, 1,4-dioxane (10 mL) was added during the process to help remove excess HCl.The product was purified by recrystallization from hot isopropanol, allowing crystals to form slowly at room temperature. The recrystallized solid was placed under high vacuum to remove residual solvent. The final yield was 0.55 g (60%). The product had a melting point of 216-218 °C, a specific spin [α]D24 of +12.0° (c 0.50, methanol), and an HPLC purity (200 nm) greater than 99% and significantly lower than 0.5% of the parent leucine.1H NMR ((CD3)2SO) δ 8.29 (broad single peak, 3H), 7.96 (single peak, 1H), 7.48 (single peak, 1H), and 3.66 (multiple peaks, 1H), 1.67 (multiple peaks, 1H), 1.56 (multiple peaks, 2H), 0.92 (double peaks, J=3Hz, 3H), 0.90 (double peaks, J=3Hz, 3H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 20, p. 5000 - 5006
[2] Journal fur Praktische Chemie - Chemiker - Zeitung, 1996, vol. 338, # 3, p. 251 - 256
L-Leucinamide hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from L-Leucinamide hydrochloride manufacturers
- Product
- L-Leucinamide hydrochloride 10466-61-2
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-07-27