ChemicalBook > CAS DataBase List > 2,4-Diaminopyrimidine

2,4-Diaminopyrimidine

Product Name: 2,4-Diaminopyrimidine
CAS No.: 156-81-0
Chemical Name: 2,4-Diaminopyrimidine
Synonyms: DAP;Pyrimidine-2,4-diamine;2,4-PYRIMIDINEDIAMINE;Diaminopyrimidine;2,4-DIAMINOPYRIMIDINE;2,6-DIAMINOPYRIMIDINE;Minoxidil Impurity 35;Minoxidil Impurity 28;Pyrimidine,2,4-diamino-;2,4-Diaminopyrimidine>
CBNumber: CB8763402
Molecular Formula: C4H6N4
Formula Weight: 110.12
MOL File: 156-81-0.mol

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2,4-Diaminopyrimidine Property

Melting point:: 143-147 °C (lit.)
Boiling point:: 401.7±37.0 °C(Predicted)
Density: 1.368±0.06 g/cm3(Predicted)
refractive index: 1.46-1.466
storage temp.: Keep in dark place,Sealed in dry,2-8°C
pka: 7.08±0.10(Predicted)
form: powder to crystal
color: White to Almost white
Water Solubility: 840 g/L (25 ºC)
InChI: InChI=1S/C4H6N4/c5-3-1-2-7-4(6)8-3/h1-2H,(H4,5,6,7,8)
InChIKey: YAAWASYJIRZXSZ-UHFFFAOYSA-N
SMILES: C1(N)=NC=CC(N)=N1
CAS DataBase Reference: 156-81-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 468231
Product name: 2,4-Diaminopyrimidine
Purity: 98%
Packaging: 1g
Price: $109
Updated: 2025/07/31

Sigma-Aldrich

Product number: 468231
Product name: 2,4-Diaminopyrimidine
Purity: 98%
Packaging: 5g
Price: $410
Updated: 2023/06/20

TCI Chemical

Product number: D2120
Product name: 2,4-Diaminopyrimidine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $188
Updated: 2025/07/31

TCI Chemical

Product number: D2120
Product name: 2,4-Diaminopyrimidine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $593
Updated: 2025/07/31

TRC

Product number: D415250
Product name: 2,4-Diaminopyrimidine
Packaging: 1g
Price: $75
Updated: 2021/12/16

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2,4-Diaminopyrimidine Chemical Properties,Usage,Production

Chemical Properties

light orange crystalline powder

Definition

ChEBI: Pyrimidine-2,4-diamine is an aminopyrimidine in which a pyrimidine nucleus is substituted with amino groups at C-2 and C-4.

Synthesis

1004-01-9

73183-34-3

156-81-0

944401-61-0

Synthesis of 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-2,4-diamine: To a dry 1L flask was added 5-bromopyrimidine-2,4-diamine (30.0 g, 158.7 mmol), potassium acetate (45.8 g, 466.7 mmol), pinacol bis(boronic acid) ester (51.16 g, 202.2 mmol) and dioxane (500 mL). After bubbling argon through the solution for 15 minutes, 1,1'-bis(diphenylphosphino)ferrocene palladium(II) chloride (2.53 g, 3.11 mmol) was added. The reaction mixture was refluxed in an oil bath at 115 °C for 16 h under argon protection. After completion of the reaction, it was cooled to room temperature, filtered to remove solid inorganic material and washed with ethyl acetate (1 L). The organic filtrate was concentrated under vacuum and dichloromethane (1 L) was added to the resulting solid. After sonication, the solid was collected by filtration and this solid was the debromination product 2,4-diaminopyrimidine. The filtrate containing the target borate was concentrated in vacuo and ether (100 mL) was added to the residue. After sonication, the filtrate was filtered and washed with additional ether (50 mL), and the resulting solid was dried under high vacuum to afford the target product 2,4-diaminopyrimidine-5-boronic acid pinacol ester (10.13 g, 27% yield). The substance was analyzed by 1H NMR as a 4:1 mixture of 2,4-diaminopyrimidine-5-boronic acid pinacol ester and 2,4-diaminopyrimidine by-product. The mixture could be used in the subsequent Suzuki reaction without further purification.LCMS (m/z): 155 (MH+ of boronic acid, derived from hydrolysis of the in situ product on LC); 1H NMR (CDCl3 + CD3OD): δ8.16 (s, 1H), 1.34 (s, 12H).

References

[1] Patent: WO2008/98058, 2008, A1. Location in patent: Page/Page column 64-65
[2] Patent: WO2007/84786, 2007, A1. Location in patent: Page/Page column 98
[3] ACS Medicinal Chemistry Letters, 2011, vol. 2, # 10, p. 774 - 779
[4] Patent: WO2012/109423, 2012, A1. Location in patent: Page/Page column 23

2,4-Diaminopyrimidine Preparation Products And Raw materials

Raw materials

3,3-Diethoxypropionitrile Guanidine hydrochloride 1-Butanol

Preparation Products

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2,4-Diaminopyrimidine Suppliers

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View Lastest Price from 2,4-Diaminopyrimidine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2,4-Diaminopyrimidine 156-81-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-22

Shaanxi Dideu New Materials Co. Ltd

Product: 2,4-Diaminopyrimidine 156-81-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-20

Dideu Industries Group Limited

Product: 2,4-Diaminopyrimidine 156-81-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-10

156-81-0, 2,4-DiaminopyrimidineRelated Search:

2-Aminopyrimidine 4,6-Dihydroxypyrimidine Iminodiacetonitrile 4,4'-Methylenedianiline 4,4'-Diaminodiphenylsulfone Diaminomaleonitrile 4-Aminopyrimidine Iminodiacetic acid 5-(3,4-Dimethoxybenzyl)-2,4-diaminopyrimidine 4,6-DIAMINOPYRIMIDINE 2,4,5-Triamino-6-chloropyrimidine hydrochloride 2,6-DIAMINOPURINE SULPHATE MONOHYDRATE 2,4-DIAMINO-6,7-DIMETHYLPTERIDINE 5-Nitroso-2,4,6-triaminopyrimidine 4-CHLORO-2,6-DIAMINOPYRIMIDINE (2,4-DIAMINO-6-CHLOROPYRIMIDINE) 2,4,6-Triaminopyrimidine 2,4-DIAMINO-6-MERCAPTOPYRIMIDINE 2,4-Diamino-6-hydroxypyrimidine ,98%

2,4-Diaminopyrimidine (sulphate)

2,4-Diaminopyrimidine,97%

2,4-Diaminopyrimidine, 2,4-Diamino-1,3-diazine

Pyrimidine-2,4-diamine 98%

2,4-PYRIMIDINEDIAMINE 98+%

2,4-DIAMINOPYRIMIDINE 97%

DAP

2,4-Pyrimidinediamine (9CI)

3-Morpholinosydnoneimine HCl

pyrimidine-2,4-diyldiamine

Diaminopyrimidine

Pyrimidine,2,4-diamino-

Pyrimidine-2,4-diamine

2,4-DIAMINOPYRIMIDINE

2,4-PYRIMIDINEDIAMINE

2,6-DIAMINOPYRIMIDINE

2,4-Diaminopyrimidine&gt

2,4-Diaminopyrimidine ISO 9001：2015 REACH

Minoxidil Impurity 35

Terbufos Impurity 3 (Terfuboxon)

Minoxidil Impurity 28

pyrimidine-2,4-diamine - [P83244]

156-81-0

C4H6N4

Heterocycle-Pyrimidine series

Building Blocks

Heterocyclic Building Blocks

Pyrimidines

APIs & Intermediate

PYRIMIDINE