2,4-Diaminopyrimidine
- Product Name
- 2,4-Diaminopyrimidine
- CAS No.
- 156-81-0
- Chemical Name
- 2,4-Diaminopyrimidine
- Synonyms
- DAP;Pyrimidine-2,4-diamine;2,4-PYRIMIDINEDIAMINE;Diaminopyrimidine;2,4-DIAMINOPYRIMIDINE;2,6-DIAMINOPYRIMIDINE;Minoxidil Impurity 35;Minoxidil Impurity 28;Pyrimidine,2,4-diamino-;2,4-Diaminopyrimidine>
- CBNumber
- CB8763402
- Molecular Formula
- C4H6N4
- Formula Weight
- 110.12
- MOL File
- 156-81-0.mol
2,4-Diaminopyrimidine Property
- Melting point:
- 143-147 °C (lit.)
- Boiling point:
- 401.7±37.0 °C(Predicted)
- Density
- 1.368±0.06 g/cm3(Predicted)
- refractive index
- 1.46-1.466
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- pka
- 7.08±0.10(Predicted)
- form
- powder to crystal
- color
- White to Almost white
- Water Solubility
- 840 g/L (25 ºC)
- InChI
- InChI=1S/C4H6N4/c5-3-1-2-7-4(6)8-3/h1-2H,(H4,5,6,7,8)
- InChIKey
- YAAWASYJIRZXSZ-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=CC(N)=N1
- CAS DataBase Reference
- 156-81-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 468231
- Product name
- 2,4-Diaminopyrimidine
- Purity
- 98%
- Packaging
- 1g
- Price
- $109
- Updated
- 2025/07/31
- Product number
- 468231
- Product name
- 2,4-Diaminopyrimidine
- Purity
- 98%
- Packaging
- 5g
- Price
- $410
- Updated
- 2023/06/20
- Product number
- D2120
- Product name
- 2,4-Diaminopyrimidine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $188
- Updated
- 2025/07/31
- Product number
- D2120
- Product name
- 2,4-Diaminopyrimidine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $593
- Updated
- 2025/07/31
- Product number
- D415250
- Product name
- 2,4-Diaminopyrimidine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
2,4-Diaminopyrimidine Chemical Properties,Usage,Production
Chemical Properties
light orange crystalline powder
Definition
ChEBI: Pyrimidine-2,4-diamine is an aminopyrimidine in which a pyrimidine nucleus is substituted with amino groups at C-2 and C-4.
Synthesis
1004-01-9
73183-34-3
156-81-0
944401-61-0
Synthesis of 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-2,4-diamine: To a dry 1L flask was added 5-bromopyrimidine-2,4-diamine (30.0 g, 158.7 mmol), potassium acetate (45.8 g, 466.7 mmol), pinacol bis(boronic acid) ester (51.16 g, 202.2 mmol) and dioxane (500 mL). After bubbling argon through the solution for 15 minutes, 1,1'-bis(diphenylphosphino)ferrocene palladium(II) chloride (2.53 g, 3.11 mmol) was added. The reaction mixture was refluxed in an oil bath at 115 °C for 16 h under argon protection. After completion of the reaction, it was cooled to room temperature, filtered to remove solid inorganic material and washed with ethyl acetate (1 L). The organic filtrate was concentrated under vacuum and dichloromethane (1 L) was added to the resulting solid. After sonication, the solid was collected by filtration and this solid was the debromination product 2,4-diaminopyrimidine. The filtrate containing the target borate was concentrated in vacuo and ether (100 mL) was added to the residue. After sonication, the filtrate was filtered and washed with additional ether (50 mL), and the resulting solid was dried under high vacuum to afford the target product 2,4-diaminopyrimidine-5-boronic acid pinacol ester (10.13 g, 27% yield). The substance was analyzed by 1H NMR as a 4:1 mixture of 2,4-diaminopyrimidine-5-boronic acid pinacol ester and 2,4-diaminopyrimidine by-product. The mixture could be used in the subsequent Suzuki reaction without further purification.LCMS (m/z): 155 (MH+ of boronic acid, derived from hydrolysis of the in situ product on LC); 1H NMR (CDCl3 + CD3OD): δ8.16 (s, 1H), 1.34 (s, 12H).
References
[1] Patent: WO2008/98058, 2008, A1. Location in patent: Page/Page column 64-65
[2] Patent: WO2007/84786, 2007, A1. Location in patent: Page/Page column 98
[3] ACS Medicinal Chemistry Letters, 2011, vol. 2, # 10, p. 774 - 779
[4] Patent: WO2012/109423, 2012, A1. Location in patent: Page/Page column 23
2,4-Diaminopyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
2,4-Diaminopyrimidine Suppliers
- Tel
- --
- Fax
- --
- chemcontrol@nextra.sk
- Country
- Slovakia
- ProdList
- 6700
- Advantage
- 60
View Lastest Price from 2,4-Diaminopyrimidine manufacturers
- Product
- 2,4-Diaminopyrimidine 156-81-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-22
- Product
- 2,4-Diaminopyrimidine 156-81-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-20
- Product
- 2,4-Diaminopyrimidine 156-81-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-10