4-Hydroxy-6-methyl-2-pyrone
- Product Name
- 4-Hydroxy-6-methyl-2-pyrone
- CAS No.
- 675-10-5
- Chemical Name
- 4-Hydroxy-6-methyl-2-pyrone
- Synonyms
- 4-HYDROXY-6-METHYL-2H-PYRAN-2-ONE;4-Hydroxy-6-methylpyran-2-one;Triacetate lactone;188-190℃;NSC 34625;AURORA KA-5368;riacetatelactone;Hydroxy-6-Methyl-2-;triaceticacidlactone;6-methy-4-hydroxy-2-pyrone
- CBNumber
- CB8767354
- Molecular Formula
- C6H6O3
- Formula Weight
- 126.11
- MOL File
- 675-10-5.mol
4-Hydroxy-6-methyl-2-pyrone Property
- Melting point:
- 188-190 °C (dec.) (lit.)
- Boiling point:
- 174.21°C (rough estimate)
- Density
- 1.2048 (rough estimate)
- refractive index
- 1.4189 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- 8.6g/l
- form
- Powder
- pka
- 5.14±0.30(Predicted)
- color
- Off-white to brown
- Water Solubility
- 8.60 g/L (20 ºC)
- BRN
- 113815
- InChI
- InChI=1S/C6H6O3/c1-4-2-5(7)3-6(8)9-4/h2-3,7H,1H3
- InChIKey
- NSYSSMYQPLSPOD-UHFFFAOYSA-N
- SMILES
- C1(=O)OC(C)=CC(O)=C1
- CAS DataBase Reference
- 675-10-5(CAS DataBase Reference)
- EPA Substance Registry System
- 2H-Pyran-2-one, 4-hydroxy-6-methyl- (675-10-5)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- RTECS
- UQ1000000
- Hazard Note
- Irritant
- TSCA
- TSCA listed
- HS Code
- 29322980
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H43415
- Product name
- 4-Hydroxy-6-methyl-2-pyrone
- Purity
- 98%
- Packaging
- 5g
- Price
- $42.4
- Updated
- 2025/07/31
- Product number
- H43415
- Product name
- 4-Hydroxy-6-methyl-2-pyrone
- Purity
- 98%
- Packaging
- 25g
- Price
- $88.2
- Updated
- 2025/07/31
- Product number
- H0715
- Product name
- 4-Hydroxy-6-methyl-2-pyrone
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $48
- Updated
- 2025/07/31
- Product number
- H0715
- Product name
- 4-Hydroxy-6-methyl-2-pyrone
- Purity
- >98.0%(GC)
- Packaging
- 500g
- Price
- $405
- Updated
- 2025/07/31
- Product number
- 25210
- Product name
- 4-Hydroxy-6-methyl-2-pyrone
- Purity
- ≥98%
- Packaging
- 1 g
- Price
- $26
- Updated
- 2024/03/01
4-Hydroxy-6-methyl-2-pyrone Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
4-Hydroxy-6-methylpyran-2-one was used in the synthesis of pyrano[3,2-c]pyridones with antiproliferative and apoptosis inducing activities. It was also used in the design of benzisothiazolone human leukocyte elastase inhibitors.
Definition
ChEBI: Triacetate lactone is a member of 2-pyranones. It is a conjugate acid of a triacetate lactone oxoanion.
Synthesis Reference(s)
Synthetic Communications, 20, p. 1931, 1990 DOI: 10.1080/00397919008053123
Synthesis
14.4g (0.1mol) isopropylidene malonate, 35ml dichloromethane and 15ml chlorobenzene were placed in the reaction flask, cooled to <5C under stirring, 10.1g (0.1mol) triethylamine and 10.1g (0.12mol) bis(vinylidene) ketone were added dropwise. After addition, slowly warmed to room temperature, continue to stir for 2 hours. The reaction was washed with cooled dilute hydrochloric acid, dried, filtered and most of the dichloromethane was removed in a rotary evaporator. The residual reactant was heated and refluxed for 2 hours, and yellow crystals were precipitated. The crystals were cooled, filtered and washed with a small amount of ether. After drying, 4-hydroxy-6-methyl-2-pyranone was obtained 10.1g, yield 82%, m.p. 186-189 (literature value 188-189 ).
4-Hydroxy-6-methyl-2-pyrone Preparation Products And Raw materials
Raw materials
Preparation Products
4-Hydroxy-6-methyl-2-pyrone Suppliers
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View Lastest Price from 4-Hydroxy-6-methyl-2-pyrone manufacturers
- Product
- 4-Hydroxy-6-methyl-2-pyrone 675-10-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.3%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18
- Product
- 4-Hydroxy-6-methyl-2-pyrone 675-10-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-28
- Product
- 4-Hydroxy-6-methyl-2-pyrone 675-10-5
- Price
- US $36.00/KG
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 500000kgs
- Release date
- 2021-08-12