ChemicalBook > CAS DataBase List > 4-Methyl-3-nitropyridine
4-Methyl-3-nitropyridine
- Product Name
- 4-Methyl-3-nitropyridine
- CAS No.
- 5832-44-0
- Chemical Name
- 4-Methyl-3-nitropyridine
- Synonyms
- 3-nitro-4-picoline;4-METHYL-3-NITROPYRIDINE;3-Nitro-4-methylpyridine;Methyl-3-nitropyridine,4-;pyridine, 4-Methyl-3-nitro-;4-Methyl-3-nitropyridine>4-Methyl-3-nitropyridine 97%;4-Methyl-3-nitropyridine,98%;Pyridine, 4-methyl-3-nitro- (9CI);4-Methyl-3-nitropyridine ISO 9001：2015 REACH
- CBNumber
- CB8769909
- Molecular Formula
- C6H6N2O2
- Formula Weight
- 138.12
- MOL File
- 5832-44-0.mol
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4-Methyl-3-nitropyridine Property
- Melting point:
- 24-28 °C
- Boiling point:
- 238 °C
- Density
- 1.228 g/mL at 25 °C
- refractive index
- n20/D 1.549
- Flash point:
- 227 °F
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to lump to clear liquid
- pka
- 1.87±0.18(Predicted)
- color
- White or Colorless to Yellow
- BRN
- 118796
- InChI
- InChI=1S/C6H6N2O2/c1-5-2-3-7-4-6(5)8(9)10/h2-4H,1H3
- InChIKey
- JLNRJMGYBKMDGI-UHFFFAOYSA-N
- SMILES
- C1=NC=CC(C)=C1[N+]([O-])=O
- CAS DataBase Reference
- 5832-44-0(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xn,T,Xi
- Risk Statements
- 22-37/38-41-36/37/38
- Safety Statements
- 26-39-36
- RIDADR
- 2810
- WGK Germany
- 3
- Hazard Note
- Harmful
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29333990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 532592
- Product name
- 4-Methyl-3-nitropyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $52.7
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- 532592
- Product name
- 4-Methyl-3-nitropyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $219
- Updated
- 2023/06/20
TCI Chemical
- Product number
- M2353
- Product name
- 4-Methyl-3-nitropyridine
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $56
- Updated
- 2023/06/20
TCI Chemical
- Product number
- M2353
- Product name
- 4-Methyl-3-nitropyridine
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $188
- Updated
- 2023/06/20
TRC
- Product number
- M220645
- Product name
- 4-Methyl-3-nitropyridine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
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4-Methyl-3-nitropyridine Chemical Properties,Usage,Production
Chemical Properties
Deliquescent cryst
Uses
4-Methyl-3-nitropyridine may be used as a starting material in the synthesis of ethyl 6-azaindole-2-carboxylate and also 3-substituted azaindoles.
Uses
4-METHYL-3-NITROPYRIDINE is a useful research chemical.
General Description
4-Methyl-3-nitropyridine, a substituted nitropyridine, can be prepared by the malonation of 4-methoxy-3-nitropyridine with sodium diethyl malonate.
Synthesis
108-89-4
5832-44-0
The general procedure for synthesizing 3-nitro-4-methylpyridine from 4-methylpyridine is as follows:1) In step 1) of Example 1, prepare a reaction solution by adding 60 g of nitrogen pentoxide solid to 300 g of liquid sulfur dioxide at -30° C. and stirring sufficiently until completely dissolved.2) Dissolve 30 g of 4-methylpyridine in 120 g of liquid sulfur dioxide and maintain the temperature at -30° C.3 ) Slowly drop the reaction solution into 300 g of ice water for 5 minutes. ) Slowly add the nitrogen pentoxide-sulfur dioxide solution prepared in step 1) dropwise to the 4-methylpyridine solution, and react for 5 min. 4) Slowly pour the reaction solution into 300 g of ice water, and hydrolyze thoroughly. 5) Adjust the pH of the hydrolyzed solution to 8-9 using sodium carbonate. 6) Add 290 g of toluene for two extractions, and combine the extracts. 7) Remove the solvent by vacuum distillation to obtain 39 g of 3- Nitro-4-methylpyridine. The purity of the product was 99.0% by gas chromatography.
References
[1] Organic and Biomolecular Chemistry, 2005, vol. 3, # 3, p. 538 - 541
[2] Acta Chemica Scandinavica, 1994, vol. 48, # 12, p. 1001 - 1006
[3] Acta Chemica Scandinavica, 1994, vol. 48, # 2, p. 181 - 182
[4] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1995, # 6, p. 1211 - 1216
[5] Acta Chemica Scandinavica, 1996, vol. 50, # 6, p. 556 - 557
4-Methyl-3-nitropyridine Preparation Products And Raw materials
Raw materials
4-Methylpyridine
Sodium sulfate
Trifluoroacetic acid
Trifluoroacetic anhydride
Ethyl acetate
Nitric acid
Dichloromethane
Sodium hydroxide
PETROLEUM ETHER
Sodium metabisulfite
Potassium nitrate
Preparation Products
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View Lastest Price from 4-Methyl-3-nitropyridine manufacturers
TAIZHOU DKD CHEMICAL CO., LTD.
- Product
- 4-Methyl-3-nitropyridine 5832-44-0
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2022-11-08
Dideu Industries Group Limited
- Product
- 4-Methyl-3-nitropyridine 5832-44-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-26
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 4-Methyl-3-nitropyridine 5832-44-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
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