ChemicalBook > CAS DataBase List > Chlorodifluoroacetic acid ethyl ester

Chlorodifluoroacetic acid ethyl ester

Product Name: Chlorodifluoroacetic acid ethyl ester
CAS No.: 383-62-0
Chemical Name: Chlorodifluoroacetic acid ethyl ester
Synonyms: Ethyl 2-chloro-2,2-difluoroacetate;ETHYL CHLORODIFLUOROACETATE;Difluorochlorate;Ethyl Difluorochloroacetate;Ethyl chlorodifluoroethanoate;Ethylchlorodifluoroacetate,98%;Ethyl chloroacetatetwo fluorine;Ethyl chlorodifluoroacetate 98%;Ethyl Chlorodifluoroacetate >chlorodifluoro-aceticaciethylester
CBNumber: CB8772600
Molecular Formula: C4H5ClF2O2
Formula Weight: 158.53
MOL File: 383-62-0.mol

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Chlorodifluoroacetic acid ethyl ester Property

Boiling point:: 96-97.5 °C (lit.)
Density: 1.252 g/mL at 25 °C (lit.)
refractive index: n20/D 1.358(lit.)
Flash point:: 65 °F
storage temp.: 2-8°C
solubility: Chloroform (Sparingly), Ethyl Acetate (Sparingly)
form: clear liquid
color: Colorless to Almost colorless
Specific Gravity: 1.252
Sensitive: Moisture Sensitive
BRN: 1761413
InChI: InChI=1S/C4H5ClF2O2/c1-2-9-3(8)4(5,6)7/h2H2,1H3
InChIKey: GVCAWQUJCHZRCB-UHFFFAOYSA-N
SMILES: C(OCC)(=O)C(Cl)(F)F
CAS DataBase Reference: 383-62-0(CAS DataBase Reference)
EPA Substance Registry System: Acetic acid, chlorodifluoro-, ethyl ester (383-62-0)

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Safety

Hazard Codes: F,C,Xi
Risk Statements: 11-34-20/21/22
Safety Statements: 16-26-27-36/37/39-45
RIDADR: UN 2924 3/PG 2
WGK Germany: 3
Hazard Note: Flammable
TSCA: Yes
HazardClass: 3
PackingGroup: II
HS Code: 29159000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 469599
Product name: Ethyl chlorodifluoroacetate
Purity: 98%
Packaging: 25ml
Price: $98.9
Updated: 2025/07/31

TCI Chemical

Product number: C1458
Product name: Ethyl Chlorodifluoroacetate
Purity: >97.0%(GC)
Packaging: 25g
Price: $79
Updated: 2025/07/31

TCI Chemical

Product number: C1458
Product name: Ethyl Chlorodifluoroacetate
Purity: >97.0%(GC)
Packaging: 500g
Price: $537
Updated: 2025/07/31

SynQuest Laboratories

Product number: 2123-7-02
Product name: Ethyl chlorodifluoroacetate
Purity: 98%
Packaging: 5G
Price: $15
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2123-7-02
Product name: Ethyl chlorodifluoroacetate
Purity: 98%
Packaging: 25g
Price: $20
Updated: 2021/12/16

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Chlorodifluoroacetic acid ethyl ester Chemical Properties,Usage,Production

Chemical Properties

clear colorless liquid

Uses

Ethyl chlorodifluoroacetate (ECDFA) may be used as a starting reagent in the synthesis of 3-gem-difluoro-2-ethoxy allylic alcohols.

General Description

Ethyl chlorodifluoroacetate (ECDFA) undergoes Reformatskii reaction with various aldehydes in DMF. It reacts with phenylacetylene to afford ethyl α,α?difluoro-4-phenyl-3-butenoates.

Synthesis

64-17-5

76-04-0

383-62-0

General procedure for the synthesis of ethyl difluorochloroacetate from ethanol and difluorochloroacetic acid: 504.3 g (3.87 mmol) of difluorochloroacetic acid and 5.0 g of p-toluenesulfonic acid were dissolved in 775 mL of dichloromethane, and 311.6 g (6.76 mol) of ethanol was slowly added over a 30-minute period at room temperature (the temperature was raised to 33 °C during the reaction). The mixture was assembled to a water condenser and stirred at reflux for 38 hours and then cooled to room temperature. The reaction mixture was washed sequentially with 200 mL of water, 200 mL of saturated sodium bicarbonate solution and 200 mL of water, followed by drying with anhydrous sodium sulfate, filtration and distillation. Further purification by fractional distillation afforded 488.9 g (98% purity, 78.5% yield) of ethyl difluorochloroacetate with a boiling point of 94-96 °C.

References

[1] Patent: WO2005/3077, 2005, A1. Location in patent: Page 13
[2] Journal of the American Chemical Society, 1957, vol. 79, p. 4174,4177

Chlorodifluoroacetic acid ethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE

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View Lastest Price from Chlorodifluoroacetic acid ethyl ester manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Chlorodifluoroacetic acid ethyl ester 383-62-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-09

Shaanxi Dideu Medichem Co. Ltd

Product: Chlorodifluoroacetic acid ethyl ester 383-62-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20t
Release date: 2024-06-25

Zhuozhou Wenxi import and Export Co., Ltd

Product: Chlorodifluoroacetic acid ethyl ester 383-62-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

383-62-0, Chlorodifluoroacetic acid ethyl esterRelated Search:

Difluorochloromethane Ethyl difluoroacetate Difluoroacetic acid METHYL DIFLUOROACETATE DIFLUOROACETIC ANHYDRIDE Ethyl bromodifluoroacetate Sodium chlorodifluoroacetate Diethyl 2,2-difluoromalonate Ethyl fluoroacetate Chlorodifluoroacetic acid ethyl ester Chlorofluoromethane Chlorodifluoroacetic acid CHLORODIFLUOROACETIC ANHYDRIDE 1-CHLORO-1-FLUOROETHANE CHLOROFLUOROACETIC ACID Ethyl chloroacetate 2-Chloroethyl ethyl ether Chloroacetic acid

Ethyl chlorodifluoroacetate 98%

Ethyl 2-chloro-2,2-difluoroacetate

Ethyl chlorodifluoroethanoate

Difluorochloroacetic acid ethyl ester

Ethyl chlorodifluoroacetate, Chlorodifluoroacetic acid ethyl ester

Ethyl 2-chloro-2,2-difluoroethanoate, Chloro(difluoro)acetic acid ethyl ester

Ethyl chloroacetatetwo fluorine

Acetic acid,2-chloro-2,2-difluoro-, ethyl ester

ETHYL CHLORODIFLUOROACETATE

CHLORODIFLUOROACETIC ACID ETHYL ESTER

Ethylchlorodifluoroacetate,98%

chlorodifluoro-aceticaciethylester

Ethyl Chlorodifluoroacetate &gt

Ethyl Difluorochloroacetate

Difluorochlorate

383-62-0

383-62-1

ClF2CCO2CH2CH3

C4H5ClF2O2

ClCF2COOC2H5

ClCF2CO2C2H5

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