Potassium canrenoate

Product Name: Potassium canrenoate
CAS No.: 2181-04-6
Chemical Name: Potassium canrenoate
Synonyms: D01943;CB 8109;Kanrenol;MF 465 a;SC 14266;Venactone;Canrenoate;Soldactona;Soldactone;Soludactone
CBNumber: CB8774235
Molecular Formula: C11H15KO2
Formula Weight: 218.33
MOL File: 2181-04-6.mol

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Potassium canrenoate Property

Melting point:: 242-244°C (dec.)
Density: 1.345 g/cm3
storage temp.: Refrigerator
solubility: Methanol (Slightly)
form: powder
color: light yellow to tan
CAS DataBase Reference: 2181-04-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36
WGK Germany: 3
RTECS: TU3500000
Toxicity: LD50 oral in rat: 650mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J61394
Product name: Canrenoic acid potassium salt, 98+%
Packaging: 1g
Price: $52.65
Updated: 2024/03/01

Alfa Aesar

Product number: J61394
Product name: Canrenoic acid potassium salt, 98+%
Packaging: 5g
Price: $153.65
Updated: 2024/03/01

Alfa Aesar

Product number: J61394
Product name: Canrenoic acid potassium salt, 98+%
Packaging: 25g
Price: $580.65
Updated: 2024/03/01

TRC

Product number: C175625
Product name: CanrenoicAcidPotassiumSalt
Packaging: 50g
Price: $1210
Updated: 2021/12/16

TRC

Product number: C175625
Product name: CanrenoicAcidPotassiumSalt
Packaging: 5g
Price: $155
Updated: 2021/12/16

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Potassium canrenoate Chemical Properties,Usage,Production

Originator

Spiroctan,Boehringer Mannheim,Switz.,1968

Uses

Canrenoic acid is an aldosterone antagonist. Canrenoic acid is used as an diuretic.

Uses

anticholithogenic, antilipemic agent

Manufacturing Process

The lactone is prepared as follows: A solution of 5 parts of 17α-carboxyethyl- 17β-hydroxyandrost-4-en-3-one lactone and 5 parts of chloranil in 400 parts of xylene containing a trace of p-toluenesulfonic acid is heated at the boiling point of the solvent under reflux overnight. The solution is then cooled and filtered through approximately 200 parts of silica gel. The gel is successively washed with 5%, 10%, and 15% ethyl acetate-benzene solutions, and the washings comprising 15% ethyl acetate are thereupon purified by chromatography on a further quantity of silica gel, using benzene and ethyl acetate as developing solvents. From the 15% ethyl acetate eluate there is obtained pure 17α-carboxyethyl-17β-hydroxyandrost-4,6-dien-3-one lactone, melting at 148° to 151°C. The product solidifies above this melting point and melts again at 165°C.

brand name

Aldactone-diurapid;Aldadiene potassium;Kadiur;Lasiren;Luvion;Osirenol;Osyrol-lasix;Phanurane;Sincomen pro injectione;Speroctan-m;Spiroctan.

Therapeutic Function

Aldosterone antagonist, Diuretic

World Health Organization (WHO)

Potassium canrenoate, which has no intrinsic aldosterone antagonist activity, owes its therapeutic effect to the enzymatic interconversion in the body to canrenone. Evidence that long-term administration of high doses are tumorigenic in the rat has recently led to restriction of its use by some national regulatory authorities. See also WHO comments for canrenone and spironolactone.

Potassium canrenoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Potassium canrenoate Suppliers

China 68 Europe 2 India 1 South Korea 1 Switzerland 1 United Kingdom 4 United States 18 Global 95

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-81124267 15229202216
Fax: 029-88380327
Email: 1073@dideu.com
Country: China
ProdList: 10011
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94838
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9664
Advantage: 60

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3750
Advantage: 55

Shanghai TaoSu Biochemical Technology Co., Ltd.

Tel: 021-33632979
Fax: 021-34692979
Email: info@tsbiochem.com
Country: China
ProdList: 8073
Advantage: 58

Jinan Putubio Tech Co., Ltd.

Tel: +86 (531) 8099-2215
Fax: +86 (531) 8099-2215
Email: putubio@outlook.com
Country: China
ProdList: 1261
Advantage: 55

Raw material medicin reagent co.,Ltd

Tel: 025-57798860
Email: sales@njromanme.com
Country: China
ProdList: 4534
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 027-59402396 13419635609
Fax: 027-83989310
Email: 13419635609@163.com
Country: China
ProdList: 1993
Advantage: 55

Wellman Pharmaceutical Group Limited

Tel: 027-027-83778875 15807197853
Fax: 027-83991220
Email: 15807197853@163.com
Country: China
ProdList: 3979
Advantage: 58

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View Lastest Price from Potassium canrenoate manufacturers

Wuhan Senwayer Century Chemical Co.,Ltd

Product: Potassium canrenoate 2181-04-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99% min
Supply Ability: 20 tons
Release date: 2022-12-02

2181-04-6, Potassium canrenoateRelated Search:

Potassium chloride Potassium iodide Potassium iodate Potassium Citrate Potassium persulfate Potassium nitrate Potassium clavulanate Potassium lactate Potassium sorbate Potassium sorbate 1,2,3-Propanetricarboxylicacid,2-hydroxy-,potassiumsalt Potassium sodium tartrate Potassium Acetate Potassium perchlorate Potassium chlorate Potassium POTASSIUM CYCLOHEXANEBUTYRATE Potassium myristate

CANRENOIC ACID POTASSIUM SALT

canrenoic acid potassium

4,6-ANDROSTADIEN-17ALPHA-YL-PROPIONIC ACID-17BETA-OL-3-ONE POTASSIUM SALT

17-HYDROXY-3-OXOPREGNA-4,6-DIENE-21-CARBOXYLIC ACID

17-HYDROXY-3-OXOPREGNA-4,6-DIENE-21-CARBOXYLIC ACID POTASSIUM SALT

POTASSIUM CANRENOATE

Canrenone, potassium salt

Canrenoate

17a-Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, monopotassium salt (8CI)

17a-Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, potassium salt (7CI)

17-Hydroxy-3-oxo-17a-pregna-4,6-diene-21-carboxylic acid potassium salt

CB 8109

Kanrenol

MF 465 a

Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, monopotassium salt, (17a)- (9CI)

SC 14266

SC 14266/371

Soldactona

Soldactone

Soludactone

Venactone

canrenone potassium

17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid, Potassium canrenoate

Canrenoate potassium (usan)

D01943

Potassium canrenoate (jp15)

Soldactone (tn)

(17α)-17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic Acid PotassiuM Salt

PotassiuM 17-Hydroxy-3-oxo-17α-pregna-4,6-diene-21-carboxylate

PotassiuM 3-(17β-Hydroxy-3-oxoandrosta-4,6-dien-17-yl)propionate

PotassiuM 3-(3-oxo-17β-hydroxy-4,6-androstadien-17α-yl)propionate

PotassiuM Aldadiene

PotassiuM β-(3-Oxo-17β-hydroxyandrosta-4,6-dien-17α-yl) Propionate

Cabrenoic Acid Potassium Salt

Potassium canrenoate 17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid potassium salt

Free acid potassium salt

CanrenoicAcidPotassiumSal

competitive,inhibit,hypertension,diuretic,SC-14266,fibrosis,Mineralocorticoid Receptor,Canrenoate potassium,SC14266,Inhibitor,Canrenoate,Aldadiene,cardiac,SC 14266

2181-04-6

C22H30O4K

C22H29KO4

CHENIX