FK 888

Product Name: FK 888
CAS No.: 138449-07-7
Chemical Name: FK 888
Synonyms: FK 888;FK888 hydrate;N(2)-(4-Hydroxy-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl)-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide;(4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide;L-Alaninamide, (4R)-4-hydroxy-1-((1-methyl-1H-indol-3-yl)carbonyl)-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-;L-Alaninamide, trans-4-hydroxy-1-((1-methyl-1H-indol-3-yl)carbonyl)-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-;N2-[(4R)-4-hydroxyl-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl]-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide hydrate;(4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide hydrate
CBNumber: CB8785831
Molecular Formula: C36H36N4O4
Formula Weight: 588.7
MOL File: 138449-07-7.mol

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FK 888 Property

Boiling point:: 901.9±65.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: ≥13mg/mL
form: powder
pka: 13.01±0.40(Predicted)
color: white to tan
optical activity: [α]/D -135 to -145°, c = 1 in methanol

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 2400
Product name: FK888
Purity: ≥98%(HPLC)
Packaging: 10
Price: $304
Updated: 2021/12/16

TRC

Product number: F370403
Product name: FK888
Packaging: 25mg
Price: $960
Updated: 2021/12/16

ApexBio Technology

Product number: B5300
Product name: FK888
Packaging: 10mg
Price: $465
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0001359
Product name: FK 888
Purity: 95.00%
Packaging: 10MG
Price: $799.21
Updated: 2021/12/16

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FK 888 Chemical Properties,Usage,Production

Uses

FK 888 is a neurokinin NK1 receptor antagonist, which is active both in vivo and in vitro.

Definition

ChEBI: (2S,4R)-4-hydroxy-1-[(1-methyl-3-indolyl)-oxomethyl]-N-[(2S)-1-[methyl-(phenylmethyl)amino]-3-(2-naphthalenyl)-1-oxopropan-2-yl]-2-pyrrolidinecarboxamide is a peptide.

Biological Activity

Selective, high affinity tachykinin NK 1 receptor antagonist (K i = 0.69 nM) that displays 320-fold selectivity for human over rat NK 1 receptors. Inhibits substance P-induced contraction of isolated guinea pig trachea (IC 50 = 32 nM) and inhibits substance P-induced airway constriction in vivo following i.v. and oral administration.

storage

Store at -20°C

FK 888 Preparation Products And Raw materials

Raw materials

Preparation Products

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FK 888 Suppliers

China 16 Germany 1 United Kingdom 1 United States 5 Global 23

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Email: sales@chemos-group.com
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138449-07-7, FK 888Related Search:

3-(NAPHTHALEN-2-YL)PROPAN-1-AMINE 2-NAPHTHALEN-2-YL-ETHYLAMINE (1-Methyl-1H-indol-3-yl)-methylamine 1H-PYRROLE-3-METHANAMINE, 1-METHYL- 1H-Indole-3-carboxamide(9CI) FK 888 1-Methylindole-3-carboxaldehyde Gramine

N2-[(4R)-4-hydroxyl-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl]-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide hydrate

FK 888

L-Alaninamide, (4R)-4-hydroxy-1-((1-methyl-1H-indol-3-yl)carbonyl)-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-

L-Alaninamide, trans-4-hydroxy-1-((1-methyl-1H-indol-3-yl)carbonyl)-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-

N(2)-(4-Hydroxy-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl)-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide

(4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide

(4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide hydrate

FK888 hydrate

138449-07-7