GW 4064
- Product Name
- GW 4064
- CAS No.
- 278779-30-9
- Chemical Name
- GW 4064
- Synonyms
- CS-278;GW 4064;GW4064;GW 4064;3-(2,6-Dichlorophenyl)-4-(3'-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole;3-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-isopropyl-4-isoxazolyl]methoxy]styryl]benzoic Acid;3-(2-Chloro-4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy)styryl)benzoic acid;3-[2-[2-Chloro-4-[3-(2,6-dichlorophenyl)-5-isopropyl-isoxazol-4-ylMethoxy]phenyl]vinyl]benzoic;GW-4064,3-[2-[2-Chloro-4-[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-ylMethoxy]phenyl]vinyl]benzoi;3-[2-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]Methoxy]phenyl]vinyl]benzoic acid;3-[2-[2-Chloro-4-[[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]-benzoic Acid
- CBNumber
- CB8799852
- Molecular Formula
- C28H22Cl3NO4
- Formula Weight
- 542.84
- MOL File
- 278779-30-9.mol
GW 4064 Property
- Melting point:
- >175°C (dec.)
- Boiling point:
- 702.1±60.0 °C(Predicted)
- Density
- 1.367±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble10mg/mL, clear
- pka
- 4.13±0.10(Predicted)
- form
- powder
- color
- white
- InChIKey
- BYTNEISLBIENSA-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=CC(C=CC2=CC=C(OCC3=C(C(C)C)ON=C3C3=C(Cl)C=CC=C3Cl)C=C2Cl)=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- G5172
- Product name
- GW4064
- Purity
- ≥97% (HPLC)
- Packaging
- 5mg
- Price
- $151
- Updated
- 2024/03/01
- Product number
- G5172
- Product name
- GW4064
- Purity
- ≥97% (HPLC)
- Packaging
- 25mg
- Price
- $586
- Updated
- 2024/03/01
- Product number
- 10006611
- Product name
- GW 4064
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 10006611
- Product name
- GW 4064
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 10006611
- Product name
- GW 4064
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $133
- Updated
- 2024/03/01
GW 4064 Chemical Properties,Usage,Production
Uses
A novel nonsteroidal FXR nuclear receptor agonist.
Uses
GW4064 has been used:
- to investigate its ability to protect the livers of mice from lipopolysaccharide (LPS)-induced inflammation and apoptosis
- to examine its capability to inhibit mucosal injury in ileum caused by lipopolysaccharide (LPS)
- to treat ileal explants
Definition
ChEBI: GW 4064 is a stilbenoid.
General Description
GW4064 is a synthetic isoxazole, which is used to decipher the cellular and physiological functions of farnesoid X receptor (FXR). It is an estrogen receptor-related receptors (ERRs) agonist.
Biological Activity
Selective, non-steroidal farnesoid X receptor (FXR) agonist (EC 50 = 15 nM). Displays no activity at other nuclear receptors at concentrations up to 1 μ M. Improves hyperglycaemia and hyperlipidaemia in diabetic db/db mice.
Biochem/physiol Actions
GW4064 is a FXR agonist. GW4064 is a potent (EC50 = 15 nM), non-steroidal agonist of the orphan nuclear receptor FXR. It shows no activity on other nuclear receptors including RAR up to 1 mM. This is an important tool for the study of the involvment of FXR in a variety of biological activities.
storage
Store at +4°C
References
[1] chiang pc, thompson dc, ghosh s, heitmeier mr. a formulation-enabled preclinical efficacy assessment of a farnesoid x receptor agonist, gw4064, in hamsters and cynomolgus monkeys. j pharm sci. 2011 nov;100(11):4722-33.
[2] watanabe m, houten sm, wang l, moschetta a, mangelsdorf dj, heyman ra, moore dd, auwerx j. bile acids lower triglyceride levels via a pathway involving fxr, shp, and srebp-1c. j clin invest. 2004 may;113(10):1408-18.
[3] li w, fu j, cheng f, zheng m, zhang j, liu g, tang y. unbinding pathways of gw4064 from human farnesoid x receptor as revealed by molecular dynamics simulations. j chem inf model. 2012 nov 26;52(11):3043-52.
GW 4064 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from GW 4064 manufacturers
- Product
- GW 4064 278779-30-9
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000t/year
- Release date
- 2023-09-08
- Product
- GW 4064 278779-30-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 100kg
- Release date
- 2019-12-26