ChemicalBook > CAS DataBase List > Gantenerumab
Gantenerumab
- Product Name
- Gantenerumab
- CAS No.
- 1043556-46-2
- Chemical Name
- Gantenerumab
- Synonyms
- Gantenerumab;Research Grade Gantenerumab;Gantenerumab (anti-Amyloid Beta);Research Grade Gantenerumab(DHC12503)
- CBNumber
- CB88080772
- Formula Weight
- 0
- MOL File
- Mol file
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Gantenerumab Property
- form
- Liquid
- color
- Colorless to light yellow
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Gantenerumab Chemical Properties,Usage,Production
Uses
Gantenerumab is a monoclonal antibody for the treatment of Alzheimer's disease being developed by Hoffmann-La Roche pharmaceuticals.
in vivo
Gantenerumab (20 mg/kg; intravenous injection; once a week; 5 months) has a protective effect in PS2APP transgenic mice and can reduce the number of Aβ amyloid plaques[1].
| Animal Model: | PS2APP transgenic mice by administering a single anti-CD4 injection[1] |
| Dosage: | 20 mg/kg |
| Administration: | Intravenous injection; once a week; 5 months |
| Result: | Reduced the number of Aβ amyloid plaques in PS2APP mice compared with vehicle controls. Specifically, in the hippocampus, neocortex, and thalamus, the plaque numbers were significantly reduced by 36%, 40%, and 70% respectively. Efficiently reduced the number of smaller plaques. Did not cause neurological or locomotor deficits. |
Gantenerumab Preparation Products And Raw materials
Raw materials
Preparation Products
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