Glembatumumab

Product Name: Glembatumumab
CAS No.: 1020264-78-1
Chemical Name: Glembatumumab
Synonyms: Glembatumumab;Glembatumumab (anti-GPNMB);Research Grade Glembatumumab;Research Grade Glembatumumab(DHG93101)
CBNumber: CB88080813
Formula Weight: 0
MOL File: Mol file

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Glembatumumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Glembatumumab Chemical Properties,Usage,Production

Uses

Glembatumumab is a fully human IgG2 monoclonal antibody directed against the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma. Glembatumumab can be coupled to the microtubule inhibitor monomethyl auristatin E to form glembatumumab vedotin. Glembatumumab vedotin is an antibody-agent coupling (ADC) with antitumor activity[1].

in vivo

Glembatumumab vedotin (i.v., 2.5 mg/kg, 3 times in 7 days) can inhibit tumor growth and is well tolerated in CB17SC scid^/ female mice with sarcomas^[2].

References

[1] Naumovski L, et al. Glembatumumab vedotin, a conjugate of an anti-glycoprotein non-metastatic melanoma protein B mAb and monomethyl auristatin E for the treatment of melanoma and breast cancer. Curr Opin Mol Ther. 2010 Apr;12(2):248-57. PMID:20373269
[2] E Anders Kolb, et al. Initial testing (stage 1) of glembatumumab vedotin (CDX-011) by the pediatric preclinical testing program. Pediatr Blood Cancer. 2014 Oct;61(10):1816-21. DOI:10.1002/pbc.25099
[3] Xiaozhong Qian, et al. Pharmacologically enhanced expression of GPNMB increases the sensitivity of melanoma cells to the CR011-vcMMAE antibody-drug conjugate. Mol Oncol. 2008 Jun;2(1):81-93. DOI:10.1016/j.molonc.2008.02.002

Glembatumumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Glembatumumab Suppliers

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1020264-78-1, GlembatumumabRelated Search:

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Glembatumumab

Research Grade Glembatumumab(DHG93101)

Research Grade Glembatumumab

Glembatumumab (anti-GPNMB)

1020264-78-1