ChemicalBook > CAS DataBase List > 2-CHLOROPYRIMIDINE-4-CARBOXAMIDE

2-CHLOROPYRIMIDINE-4-CARBOXAMIDE

Product Name
2-CHLOROPYRIMIDINE-4-CARBOXAMIDE
CAS No.
22536-66-9
Chemical Name
2-CHLOROPYRIMIDINE-4-CARBOXAMIDE
Synonyms
NSC 60802;2-CHLOROPYRIMIDINE-4-CARBOXAMIDE;2-chloro-4-Pyrimidinecarboxamide;4-Pyrimidinecarboxamide, 2-chloro-;2-Chloro-pyrimidine-4-carboxylic acid amide;4-(Aminocarbonyl)-2-chloropyrimidine, 4-Carbamoyl-2-chloropyrimidine
CBNumber
CB8829193
Molecular Formula
C5H4ClN3O
Formula Weight
157.56
MOL File
22536-66-9.mol
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2-CHLOROPYRIMIDINE-4-CARBOXAMIDE Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
Appearance
White to off-white Solid
InChI
InChI=1S/C5H4ClN3O/c6-5-8-2-1-3(9-5)4(7)10/h1-2H,(H2,7,10)
InChIKey
UXXQEVFRPLIOHJ-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=CC(C(N)=O)=N1
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36
HS Code 
29242990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C597780
Product name
2-Chloropyrimidine-4-carboxamide
Packaging
500mg
Price
$220
Updated
2021/12/16
Usbiological
Product number
295672
Product name
2-Chloropyrimidine-4-carboxamide
Packaging
100mg
Price
$363
Updated
2021/12/16
Biosynth Carbosynth
Product number
NC57418
Product name
2-Chloropyrimidine-4-carboxamide
Packaging
2g
Price
$543.4
Updated
2021/12/16
Matrix Scientific
Product number
070084
Product name
2-Chloropyrimidine-4-carboxamide
Purity
96%
Packaging
1g
Price
$605
Updated
2021/12/16
Biosynth Carbosynth
Product number
NC57418
Product name
2-Chloropyrimidine-4-carboxamide
Packaging
500mg
Price
$155
Updated
2021/12/16
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2-CHLOROPYRIMIDINE-4-CARBOXAMIDE Chemical Properties,Usage,Production

Chemical Properties

Light yellow solid

Uses

2-Chloropyrimidine-4-carboxamide is used as an organic synthesis and pharmaceutical intermediate.

Synthesis

149849-92-3

22536-66-9

General procedure for the synthesis of 2-chloropyrimidine-4-carboxamide from 2-chloropyrimidine-4-carboxylic acid: 2-chloropyrimidine-4-carboxylic acid (500 mg, 1.00 eq.) was dissolved in thionyl chloride (10 mL) and the reaction was heated to 90 °C for 30 min. Upon completion of the reaction, the excess thionyl chloride was removed by concentration under reduced pressure. The residue was cooled to 0 °C and ammonium hydroxide solution (20 mL) was slowly added. The reaction mixture was extracted with dichloromethane (20 mL x 3), the organic phases were combined and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give 320 mg of 2-chloropyrimidine-4-carboxamide as a white solid. The product was analyzed by LC-MS (electrospray ionization, m/z): 158 [M+H]+.

References

[1] Patent: WO2015/25026, 2015, A1. Location in patent: Page/Page column 209

2-CHLOROPYRIMIDINE-4-CARBOXAMIDE Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Ethanol Potassium hydroxide Acetone Ethyl formate Hydrogen peroxide Sodium Phosphorus oxitrichloride Urea Sodium iodide Sodium nitrite Hydroquinone N,N-Dimethylaniline Diethyl ether Ethyl acetate Hydrochloric acid Acetic acid Bromoethane

Preparation Products

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2-CHLOROPYRIMIDINE-4-CARBOXAMIDE Suppliers

China 72 Germany 1 India 1 United Kingdom 2 United States 7 Global 83
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
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View Lastest Price from 2-CHLOROPYRIMIDINE-4-CARBOXAMIDE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-chloro-4-Pyrimidinecarboxamide 22536-66-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-29
Shaanxi Dideu Medichem Co. Ltd
Product
2-chloropyrimidine-4-carboxamide 22536-66-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-15
Nanjing jinheyou Trading Co., Ltd.
Product
2-CHLOROPYRIMIDINE-4-CARBOXAMIDE 22536-66-9
Price
US $0.00/g
Min. Order
1g
Purity
95%min
Supply Ability
20kg/month
Release date
2019-12-19

22536-66-9, 2-CHLOROPYRIMIDINE-4-CARBOXAMIDERelated Search:

FLONICAMID N4-PHENYL-2-CHLORO-6-METHYLPYRIMIDINE-4-CARBOXAMIDE 2-CHLOROPYRIMIDINE-4-CARBOXAMIDE N'1-[(2-CHLORO-6-METHYLPYRIMIDIN-4-YL)CARBONYL]-3-(TRIFLUOROMETHYL)BENZENE-1-CARBOHYDRAZIDE N'4-[(6-CHLORO-3-PYRIDYL)CARBONYL]-2-CHLORO-6-METHYLPYRIMIDINE-4-CARBOHYDRAZIDE N1-(4-CHLOROPHENYL)-2-[(2-CHLORO-6-METHYLPYRIMIDIN-4-YL)CARBONYL]HYDRAZINE-1-CARBOXAMIDE 2-CHLORO-6-METHYLPYRIMIDINE-4-CARBOHYDRAZIDE N1-PHENYL-2-[(2-CHLORO-6-METHYLPYRIMIDIN-4-YL)CARBONYL]HYDRAZINE-1-CARBOXAMIDE N1-(3-METHYLPHENYL)-2-[(2-CHLORO-6-METHYLPYRIMIDIN-4-YL)CARBONYL]HYDRAZINE-1-CARBOXAMIDE N'1-[(2-CHLORO-6-METHYLPYRIMIDIN-4-YL)CARBONYL]-2-(TRIFLUOROMETHOXY)BENZENE-1-CARBOHYDRAZIDE

  • 4-(Aminocarbonyl)-2-chloropyrimidine, 4-Carbamoyl-2-chloropyrimidine
  • 2-Chloro-pyrimidine-4-carboxylic acid amide
  • 2-CHLOROPYRIMIDINE-4-CARBOXAMIDE
  • NSC 60802
  • 2-chloro-4-Pyrimidinecarboxamide
  • 4-Pyrimidinecarboxamide, 2-chloro-
  • 22536-66-9
  • Building Blocks
  • Pyrimidine