ChemicalBook > CAS DataBase List > 2-CHLOROPYRIMIDINE-4-CARBOXAMIDE

2-CHLOROPYRIMIDINE-4-CARBOXAMIDE

Product Name
2-CHLOROPYRIMIDINE-4-CARBOXAMIDE
CAS No.
22536-66-9
Chemical Name
2-CHLOROPYRIMIDINE-4-CARBOXAMIDE
Synonyms
NSC 60802;2-CHLOROPYRIMIDINE-4-CARBOXAMIDE;2-chloro-4-Pyrimidinecarboxamide;4-Pyrimidinecarboxamide, 2-chloro-;2-Chloro-pyrimidine-4-carboxylic acid amide;4-(Aminocarbonyl)-2-chloropyrimidine, 4-Carbamoyl-2-chloropyrimidine
CBNumber
CB8829193
Molecular Formula
C5H4ClN3O
Formula Weight
157.56
MOL File
22536-66-9.mol
More
Less

2-CHLOROPYRIMIDINE-4-CARBOXAMIDE Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
Appearance
White to off-white Solid
InChI
InChI=1S/C5H4ClN3O/c6-5-8-2-1-3(9-5)4(7)10/h1-2H,(H2,7,10)
InChIKey
UXXQEVFRPLIOHJ-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=CC(C(N)=O)=N1
More
Less

Safety

Risk Statements 
36/37/38
Safety Statements 
26-36
HS Code 
29242990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
C597780
Product name
2-Chloropyrimidine-4-carboxamide
Packaging
500mg
Price
$220
Updated
2021/12/16
Usbiological
Product number
295672
Product name
2-Chloropyrimidine-4-carboxamide
Packaging
100mg
Price
$363
Updated
2021/12/16
Biosynth Carbosynth
Product number
NC57418
Product name
2-Chloropyrimidine-4-carboxamide
Packaging
2g
Price
$543.4
Updated
2021/12/16
Matrix Scientific
Product number
070084
Product name
2-Chloropyrimidine-4-carboxamide
Purity
96%
Packaging
1g
Price
$605
Updated
2021/12/16
Biosynth Carbosynth
Product number
NC57418
Product name
2-Chloropyrimidine-4-carboxamide
Packaging
500mg
Price
$155
Updated
2021/12/16
More
Less

2-CHLOROPYRIMIDINE-4-CARBOXAMIDE Chemical Properties,Usage,Production

Chemical Properties

Light yellow solid

Uses

2-Chloropyrimidine-4-carboxamide is used as an organic synthesis and pharmaceutical intermediate.

Synthesis

149849-92-3

22536-66-9

General procedure for the synthesis of 2-chloropyrimidine-4-carboxamide from 2-chloropyrimidine-4-carboxylic acid: 2-chloropyrimidine-4-carboxylic acid (500 mg, 1.00 eq.) was dissolved in thionyl chloride (10 mL) and the reaction was heated to 90 °C for 30 min. Upon completion of the reaction, the excess thionyl chloride was removed by concentration under reduced pressure. The residue was cooled to 0 °C and ammonium hydroxide solution (20 mL) was slowly added. The reaction mixture was extracted with dichloromethane (20 mL x 3), the organic phases were combined and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give 320 mg of 2-chloropyrimidine-4-carboxamide as a white solid. The product was analyzed by LC-MS (electrospray ionization, m/z): 158 [M+H]+.

References

[1] Patent: WO2015/25026, 2015, A1. Location in patent: Page/Page column 209

2-CHLOROPYRIMIDINE-4-CARBOXAMIDE Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Ethanol Potassium hydroxide Acetone Ethyl formate Hydrogen peroxide Sodium Phosphorus oxitrichloride Urea Sodium iodide Sodium nitrite Hydroquinone N,N-Dimethylaniline Diethyl ether Ethyl acetate Hydrochloric acid Acetic acid Bromoethane

Preparation Products

More
Less

2-CHLOROPYRIMIDINE-4-CARBOXAMIDE Suppliers

China 72 Germany 1 India 1 United Kingdom 2 United States 7 Global 83
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Princeton BioMolecular Research, Inc.
Tel
--
Fax
--
Email
info@princetonbio.com
Country
United States
ProdList
6934
Advantage
51
More
Less

View Lastest Price from 2-CHLOROPYRIMIDINE-4-CARBOXAMIDE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-chloro-4-Pyrimidinecarboxamide 22536-66-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-29
Shaanxi Dideu Medichem Co. Ltd
Product
2-chloropyrimidine-4-carboxamide 22536-66-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-15
Nanjing jinheyou Trading Co., Ltd.
Product
2-CHLOROPYRIMIDINE-4-CARBOXAMIDE 22536-66-9
Price
US $0.00/g
Min. Order
1g
Purity
95%min
Supply Ability
20kg/month
Release date
2019-12-19

22536-66-9, 2-CHLOROPYRIMIDINE-4-CARBOXAMIDERelated Search:

FLONICAMID N4-PHENYL-2-CHLORO-6-METHYLPYRIMIDINE-4-CARBOXAMIDE 2-CHLOROPYRIMIDINE-4-CARBOXAMIDE N'1-[(2-CHLORO-6-METHYLPYRIMIDIN-4-YL)CARBONYL]-3-(TRIFLUOROMETHYL)BENZENE-1-CARBOHYDRAZIDE N'4-[(6-CHLORO-3-PYRIDYL)CARBONYL]-2-CHLORO-6-METHYLPYRIMIDINE-4-CARBOHYDRAZIDE N1-(4-CHLOROPHENYL)-2-[(2-CHLORO-6-METHYLPYRIMIDIN-4-YL)CARBONYL]HYDRAZINE-1-CARBOXAMIDE 2-CHLORO-6-METHYLPYRIMIDINE-4-CARBOHYDRAZIDE N1-PHENYL-2-[(2-CHLORO-6-METHYLPYRIMIDIN-4-YL)CARBONYL]HYDRAZINE-1-CARBOXAMIDE N1-(3-METHYLPHENYL)-2-[(2-CHLORO-6-METHYLPYRIMIDIN-4-YL)CARBONYL]HYDRAZINE-1-CARBOXAMIDE N'1-[(2-CHLORO-6-METHYLPYRIMIDIN-4-YL)CARBONYL]-2-(TRIFLUOROMETHOXY)BENZENE-1-CARBOHYDRAZIDE

  • 4-(Aminocarbonyl)-2-chloropyrimidine, 4-Carbamoyl-2-chloropyrimidine
  • 2-Chloro-pyrimidine-4-carboxylic acid amide
  • 2-CHLOROPYRIMIDINE-4-CARBOXAMIDE
  • NSC 60802
  • 2-chloro-4-Pyrimidinecarboxamide
  • 4-Pyrimidinecarboxamide, 2-chloro-
  • 22536-66-9
  • Building Blocks
  • Pyrimidine