Suplatast tosilate
- Product Name
- Suplatast tosilate
- CAS No.
- 94055-76-2
- Chemical Name
- Suplatast tosilate
- Synonyms
- Suplatast tosylate;IPD-1151T;Suplatast;SUPLATAST TOSILATE;Suplatast Tosylate >Methotrexate Impurity 47;Suplatast tosilate USP/EP/BP;Suplatast Tosylate (IPD 1151T);TIANFU CHEM--Suplatast tosilate;N,N-dimethyl-2-propyl-1-pentanamine
- CBNumber
- CB8837187
- Molecular Formula
- C23H33NO7S2
- Formula Weight
- 499.64062
- MOL File
- 94055-76-2.mol
Suplatast tosilate Property
- Melting point:
- 84-87°C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO: >20mg/mL
- form
- powder
- color
- white to off-white
- Merck
- 14,9003
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
- CAS DataBase Reference
- 94055-76-2(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- RTECS
- WR7906000
- HS Code
- 2930.90.2900
- Toxicity
- LD50 in male, female mice, male, female rats (mg/kg): 81, 96, 96, 93 i.v.; in mice, rats (g/kg): >12.5, >10 orally (Yamashita)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S4701
- Product name
- Suplatast tosylate
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $347
- Updated
- 2024/03/01
- Product number
- S4701
- Product name
- Suplatast tosylate
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $77.6
- Updated
- 2022/05/15
- Product number
- S0875
- Product name
- Suplatast Tosylate
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 100mg
- Price
- $51
- Updated
- 2024/03/01
- Product number
- S0875
- Product name
- Suplatast Tosylate
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 1g
- Price
- $303
- Updated
- 2024/03/01
- Product number
- 30316
- Product name
- Suplatast (tosylate)
- Packaging
- 50mg
- Price
- $68
- Updated
- 2024/03/01
Suplatast tosilate Chemical Properties,Usage,Production
Description
Suplatast tosylate is a unique dimethylsulfonium salt marketed in Japan for the treatment of bronchial asthma, atopic dermatitis and allergic rhinitis. Suplatast tosylate is a potent inhibitor of IgE synthesis without suppressing IgM and IgG. The mechanism of action for suplatast tosylate is thought to be via the inhibition of interleukin-4 and interleukin-6 production by T-cells at the gene level. In allergic patients, suplatast tosylate markedly improved clinical symptoms which correlated with a significant decrease in serum IgE antibody levels.
Description
Suplatast is an antiallergic agent. It inhibits IL-4 and IL-5 production in conalbumin-stimulated D10.G4.1 murine T helper 2 (Th2) cells in a concentration-dependent manner. Suplatast (100 mg/kg) inhibits ovalbumin-induced increases in eosinophil and total cell numbers, as well as IL-4, IL-5, and IL-13, but not IFN-γ, levels in bronchoalveolar lavage fluid (BALF) in an ovalbumin-sensitized mouse model of asthma. It also inhibits ovalbumin-induced increases in ovalbumin-specific IgE in serum and bronchial hyperresponsiveness to methacholine in the ovalbumin-sensitized mouse model of asthma.
Originator
Taiho (Japan)
Uses
Suplatast Tosylate is an antiallergic drug. Suplatast Tosylate inhibits antigen-induced histamine release from mast cells as well as IgE antibody formation. Suplatast Tosylate suppresses interleukin (IL)-4 release from T cells, however in human peripheral basophils, Suplatast Tosylate inhibited the antigen-induced release of IL-13 but not IL-4.
Uses
Suplatast Tosilate is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM.
brand name
IPD
Biological Activity
Th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN- γ production. Acts as an immunoregulator that suppresses IgE production, eosinophil infiltration and histamine release. Exhibits antiasthmatic, anti-inflammatory and antifibrotic activity in vivo and is orally active.
References
1) Kurokawa?et al.?(2001),?Suppressive effects of anti-allergic agent suplatast tosilate (IPD-1151T) on the expression of co-stimulatory molecules on mouse splenocytes in vivo; Mediators Inflamm.,?10?333 2) Hsu?et al.?(2007),?The effects of suplatast tosilate (IPD-1151T) on innate immunity and antigen-presenting cells; Transpl. Immunol.,?18?108 3) Furonaka?et al.?(2009),?Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice; Curr. Opin. J. Pharmacol. Exp. Ther.,?328?55 4) Bhattachrya?et al.?(2014),?Simultaneous inhibition of T helper 2 and T regulatory cell differentiation by small molecules enhances Bacillus Calmette-Guerin vaccine efficacy against tuberculosis; J. Biol. Chem.,?289?33404 5) Wada?et al.?(2009),?Effect of suplatast tosilate on antileukotriene non-responders with mild-to-moderate persistent asthma; Allergol. Int.,?58?389
Suplatast tosilate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Suplatast tosilate manufacturers
- Product
- Suplatast tosilate 94055-76-2
- Price
- US $65.40-800.00/g
- Min. Order
- 1g
- Purity
- 0.98
- Supply Ability
- 10kg
- Release date
- 2023-12-25
- Product
- Suplatast tosilate 94055-76-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-19
- Product
- Suplatast tosilate 94055-76-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2023-03-01