5-AMINO-1,3-DIHYDROXYMETHYLBENZENE
Uses- Product Name
- 5-AMINO-1,3-DIHYDROXYMETHYLBENZENE
- CAS No.
- 71176-54-0
- Chemical Name
- 5-AMINO-1,3-DIHYDROXYMETHYLBENZENE
- Synonyms
- (5-Amino-1,3-phenylene)dimethanol;(5-Amino-1,3-phenylene);3,5-Di(hydroxymethyl)aniline;5-amino-1,3-Benzenedimethanol;1,3-Benzenedimethanol,5-amino-;5-AMINO-1,3-DIHYDROXYMETHYLBENZENE;(3-AMino-5-hydroxyMethyl-phenyl)-Methanol
- CBNumber
- CB8847524
- Molecular Formula
- C8H11NO2
- Formula Weight
- 153.18
- MOL File
- 71176-54-0.mol
5-AMINO-1,3-DIHYDROXYMETHYLBENZENE Property
- Melting point:
- 98 °C
- Boiling point:
- 388.5±32.0 °C(Predicted)
- Density
- 1.283±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 14.16±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A634830
- Product name
- (5-Amino-1,3-phenylene)dimethanol
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- CS-W007237
- Product name
- (5-Amino-1,3-phenylene)dimethanol
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- CS-W007237
- Product name
- (5-Amino-1,3-phenylene)dimethanol
- Packaging
- 5g
- Price
- $208
- Updated
- 2021/12/16
- Product number
- CS-W007237
- Product name
- (5-Amino-1,3-phenylene)dimethanol
- Packaging
- 10g
- Price
- $364
- Updated
- 2021/12/16
- Product number
- 3067AJ
- Product name
- 5-Amino-1,3-dihydroxymethylbenzene
- Packaging
- 10g
- Price
- $514
- Updated
- 2021/12/16
5-AMINO-1,3-DIHYDROXYMETHYLBENZENE Chemical Properties,Usage,Production
Uses
(5-Amino-1,3-phenylene)dimethanol is a useful research chemical, a reagent in the synthesis of nucleic acid analogs consisting of a benzene-phosphate backbone.
Synthesis
71176-55-1
71176-54-0
5-Nitro-m-xylene-α,α′-diol (1.07 g, 5.84 mmol) was used as the starting material, which was dissolved in methanol (50 mL) and Pd/C (10%, 311 mg, 0.29 mmol) was added as a catalyst. The hydrogenation reaction was carried out at 5 psi hydrogen pressure for 2 h at room temperature after hydrogen was introduced to displace the air in the reaction system. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated by rotary evaporation to afford 5-amino-m-xylene-α,α′-diol (26) as a white solid (900 mg, 100% yield).1H NMR (400 MHz, MeOD): δ 6.71 (s, 1H), 6.66 (s, 2H), 4.51 (s, 4H); 13C NMR (400 MHz, MeOD): δ 148.9, 143.8, 116.7, 114.3, 65.5. Compound 26 was dissolved in anhydrous acetonitrile (30 mL), and ethyl bromoacetate (443 μL, 4.67 mmol) and potassium carbonate (807 mg, 5.84 mmol) were added sequentially. The reaction mixture was refluxed at 86 °C in an oil bath for 17 hours. At the end of the reaction, it was cooled to room temperature, diluted with dichloromethane, filtered through diatomaceous earth and the solid was washed with dichloromethane. A white precipitate precipitated from the filtrate and was collected by filtration to afford 5-amino-1,3-dihydroxymethylbenzene (27) as a white solid (414 mg, 39% yield).1H NMR (400 MHz, MeOD): δ 6.67 (s, 1H), 6.53 (s, 2H), 4.51 (s, 4H), 3.94 (s, 2H), 3.73 (s, 3H ); 13C NMR (400 MHz, MeOD): δ 174.0, 149.7, 143.9, 116.2, 111.6, 65.6, 52.6, 46.5; MS (m/z): measured value 248.0 (M + Na)+.
References
[1] Patent: WO2010/91150, 2010, A1. Location in patent: Page/Page column 119-120
[2] Chemische Berichte, 1985, vol. 118, # 3, p. 1204 - 1229
5-AMINO-1,3-DIHYDROXYMETHYLBENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-AMINO-1,3-DIHYDROXYMETHYLBENZENE manufacturers
- Product
- 5-AMINO-1,3-DIHYDROXYMETHYLBENZENE 71176-54-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-04-29