N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA
- Product Name
- N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA
- CAS No.
- 501925-31-1
- Chemical Name
- N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA
- Synonyms
- CS-224;PNU 120596;Nsc 216666;PNU 120596 NEW;PNU120596 PNU-120596;PNU-120596 (NSC-216666);PNU-120596;PNU120596; NSC 216666;PNU-120596 - CAS 501925-31-1 - Calbiochem;1-(5-Chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea;N-(5-Chloro-2,4-dimethoxphenyl)-N'-(5-methyl-3-isoxazolyl)-urea
- CBNumber
- CB8850568
- Molecular Formula
- C13H14ClN3O4
- Formula Weight
- 311.72
- MOL File
- 501925-31-1.mol
N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA Property
- Boiling point:
- 385.0±42.0 °C(Predicted)
- Density
- 1.403
- storage temp.
- room temp
- solubility
- DMSO: >10mg/mL
- form
- White solid
- pka
- 11.72±0.70(Predicted)
- color
- white to off-white
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P0043
- Product name
- PNU-120596
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $132
- Updated
- 2024/03/01
- Product number
- 528201
- Product name
- PNU-120596
- Packaging
- 10mg
- Price
- $225
- Updated
- 2024/03/01
- Product number
- 14304
- Product name
- PNU-120596
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 14304
- Product name
- PNU-120596
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $87
- Updated
- 2024/03/01
- Product number
- P0043
- Product name
- PNU-120596
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $505
- Updated
- 2024/03/01
N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA Chemical Properties,Usage,Production
Uses
PNU 120596 is a type II positive allosteric modulator.
Definition
ChEBI: 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea is a member of ureas.
Biological Activity
Positive allosteric modulator of α 7 neuronal nicotinic acetylcholine receptors (EC 50 = 216 nM), with no detectable effect on α 4 β 2, α 3 β 4 and α 9 α 10 receptors. Active in vivo following systemic administration.
Biochem/physiol Actions
An allosteric modulator of α7 nicotinic receptors, N-(5-chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholinePNU-120596 is a positive allosteric modulator selective for the α7 nicotinic acetylcholine receptor. PNU-120596 produces no detectable change in currents mediated by α4β2, α3β4, α9α10 nAChRs. It increases channel mean open time, but does not affect ion selectivity. It does not bind at the agonist binding site, but induces conformational changes similar to the natural effector.
storage
Desiccate at +4°C
References
[1] hurst r s, hajós m, raggenbass m, et al. a novel positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. the journal of neuroscience, 2005, 25(17): 4396-4405.
[2] bertrand d, gopalakrishnan m. allosteric modulation of nicotinic acetylcholine receptors. biochemical pharmacology, 2007, 74(8): 1155-1163.
N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA manufacturers
- Product
- N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA 501925-31-1
- Price
- US $1.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1lg; 2kg; 5kg; 10kg; 100kg
- Release date
- 2019-08-31