ChemicalBook > CAS DataBase List > N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA

N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA

Product Name
N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA
CAS No.
501925-31-1
Chemical Name
N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA
Synonyms
CS-224;PNU 120596;Nsc 216666;PNU 120596 NEW;PNU120596 PNU-120596;PNU-120596 (NSC-216666);PNU-120596;PNU120596; NSC 216666;PNU-120596 - CAS 501925-31-1 - Calbiochem;1-(5-Chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea;N-(5-Chloro-2,4-dimethoxphenyl)-N'-(5-methyl-3-isoxazolyl)-urea
CBNumber
CB8850568
Molecular Formula
C13H14ClN3O4
Formula Weight
311.72
MOL File
501925-31-1.mol
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N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA Property

Boiling point:
385.0±42.0 °C(Predicted)
Density 
1.403
storage temp. 
room temp
solubility 
DMSO: >10mg/mL
form 
White solid
pka
11.72±0.70(Predicted)
color 
white to off-white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P0043
Product name
PNU-120596
Purity
≥98% (HPLC)
Packaging
5mg
Price
$132
Updated
2024/03/01
Sigma-Aldrich
Product number
528201
Product name
PNU-120596
Packaging
10mg
Price
$225
Updated
2024/03/01
Cayman Chemical
Product number
14304
Product name
PNU-120596
Purity
≥98%
Packaging
5mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
14304
Product name
PNU-120596
Purity
≥98%
Packaging
10mg
Price
$87
Updated
2024/03/01
Sigma-Aldrich
Product number
P0043
Product name
PNU-120596
Purity
≥98% (HPLC)
Packaging
25mg
Price
$505
Updated
2024/03/01
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N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA Chemical Properties,Usage,Production

Uses

PNU 120596 is a type II positive allosteric modulator.

Definition

ChEBI: 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea is a member of ureas.

Biological Activity

Positive allosteric modulator of α 7 neuronal nicotinic acetylcholine receptors (EC 50 = 216 nM), with no detectable effect on α 4 β 2, α 3 β 4 and α 9 α 10 receptors. Active in vivo following systemic administration.

Biochem/physiol Actions

An allosteric modulator of α7 nicotinic receptors, N-(5-chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholinePNU-120596 is a positive allosteric modulator selective for the α7 nicotinic acetylcholine receptor. PNU-120596 produces no detectable change in currents mediated by α4β2, α3β4, α9α10 nAChRs. It increases channel mean open time, but does not affect ion selectivity. It does not bind at the agonist binding site, but induces conformational changes similar to the natural effector.

storage

Desiccate at +4°C

References

[1] hurst r s, hajós m, raggenbass m, et al. a novel positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. the journal of neuroscience, 2005, 25(17): 4396-4405.
[2] bertrand d, gopalakrishnan m. allosteric modulation of nicotinic acetylcholine receptors. biochemical pharmacology, 2007, 74(8): 1155-1163.

N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA Suppliers

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View Lastest Price from N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA manufacturers

Career Henan Chemical Co
Product
N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA 501925-31-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1lg; 2kg; 5kg; 10kg; 100kg
Release date
2019-08-31

501925-31-1, N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREARelated Search:

Tivantinib (ARQ 197) Selumetinib LY2109761 A 769662 Erlotinib hydrochloride Veliparib 5-Chloro-2,4-dimethoxyaniline 3-Aminoisoxazole 3-Amino-5-methylisoxazole 1-(4-METHOXYPHENYL)-3-METHYLUREA N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA 2,4-DIMETHOXYANILINE HYDROCHLORIDE, 99 4-Chlororesorcinol 2-HYDROXY-4-METHOXYANILINE HYDROCHLORIDE O-METHOXYPHENYLUREA METOXURON-MONOMETHYL

  • PNU 120596
  • N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA
  • N-(5-Chloro-2,4-dimethoxphenyl)-N'-(5-methyl-3-isoxazolyl)-urea
  • 1-(5-Chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea
  • Nsc 216666
  • Urea, N-(5-chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-
  • PNU-120596;PNU120596; NSC 216666
  • CS-224
  • 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-1,2-oxazol-3-yl)urea
  • PNU-120596 - CAS 501925-31-1 - Calbiochem
  • PNU 120596 NEW
  • N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA USP/EP/BP
  • PNU-120596 (NSC-216666)
  • PNU120596 PNU-120596
  • 501925-31-1
  • 501928-31-1
  • C13H14ClN3O4
  • Inhibitors