ChemicalBook > CAS DataBase List > 2,6-Dimethyl-4-heptanone

2,6-Dimethyl-4-heptanone

Product Name
2,6-Dimethyl-4-heptanone
CAS No.
108-83-8
Chemical Name
2,6-Dimethyl-4-heptanone
Synonyms
DIBK;DIISOBUTYL KETONE;ISOBUTYL KETONE;2,6-Dimethylheptan-4-one;VALERONE;FEMA 3537;NSC 15136;isovaleron;NSC 406913;ISOVALERONE
CBNumber
CB8852764
Molecular Formula
C9H18O
Formula Weight
142.24
MOL File
108-83-8.mol
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2,6-Dimethyl-4-heptanone Property

Melting point:
-46 °C
Boiling point:
165-170 °C(lit.)
Density 
0.808 g/mL at 25 °C(lit.)
vapor density 
4.9 (vs air)
vapor pressure 
1.7 mm Hg ( 20 °C)
refractive index 
n20/D 1.412(lit.)
FEMA 
3537 | 2,6-DIMETHYL-4-HEPTANONE
Flash point:
120 °F
storage temp. 
Store below +30°C.
solubility 
Miscible with ethanol, ether, carbon tetrachloride, chloroform, benzene and most organic liquids.
form 
Liquid
Specific Gravity
0.810 (20/4℃)
color 
Clear colorless to slightly yellow
Odor
Sweet Pineapple-Banana-like fruity taste, but with a somewhat harsh chemical note.
Odor Type
green
explosive limit
0.8-6.2%, 100°F
Water Solubility 
0.05 g/100 mL
JECFA Number
302
BRN 
1743163
Henry's Law Constant
6.36(x 10-4 atm?m3/mol) at 20 °C (approximate - calculated from water solubility and vapor pressure)
Dielectric constant
9.9100000000000001
Exposure limits
TLV-TWA 150 mg/m3 (25 ppm); IDLH 1000 ppm.
Stability:
Stable. Flammable. Incompatible with strong oxidizing agents.
LogP
3.71 at 20℃
CAS DataBase Reference
108-83-8(CAS DataBase Reference)
NIST Chemistry Reference
4-Heptanone, 2,6-dimethyl-(108-83-8)
EPA Substance Registry System
Diisobutyl ketone (108-83-8)
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Safety

Hazard Codes 
Xi
Risk Statements 
10-37
Safety Statements 
24
RIDADR 
UN 1157 3/PG 3
OEB
A
OEL
TWA: 25 ppm (150 mg/m3)
WGK Germany 
1
RTECS 
MJ5775000
Autoignition Temperature
745 °F
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29141990
Hazardous Substances Data
108-83-8(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 5750 mg/kg LD50 dermal Rabbit 16000 mg/kg
IDLA
500 ppm
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.18831
Product name
Diisobutyl ketone
Purity
for synthesis
Packaging
1L
Price
$65.3
Updated
2024/03/01
Sigma-Aldrich
Product number
273848
Product name
2,6-Dimethyl-4-heptanone
Purity
99%
Packaging
25g
Price
$123
Updated
2024/03/01
Sigma-Aldrich
Product number
273848
Product name
2,6-Dimethyl-4-heptanone
Purity
99%
Packaging
100g
Price
$399
Updated
2024/03/01
Sigma-Aldrich
Product number
8.18831
Product name
Diisobutyl ketone
Purity
for synthesis
Packaging
100mL
Price
$23
Updated
2023/06/20
TCI Chemical
Product number
D0733
Product name
2,6-Dimethyl-4-heptanone
Purity
>90.0%(GC)
Packaging
25mL
Price
$16
Updated
2024/03/01
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2,6-Dimethyl-4-heptanone Chemical Properties,Usage,Production

Description

2, 6-Dimethyl-4-heptanone, also known as diisobutyl ketone, belongs to the family of ketones, being a flavoring ingredient. It can also be used as the extraction solvent for the determination of ten trace metals (V, Cr, Fe, Co, Ni, Cu, Zn, Mo, Cd, Pb) in aqueous samples with plasma atomic emission spectrometry. Similar logic can also be applied to the measurement of phosphorus using 2, 6-dimethyl-4-heptanone as the extraction agent. It is also an important organic solvent widely used as industrial intermediates.

Chemical Properties

5-Methyl-3-heptanone is a colorless liquid with low solubility in water (0.3 wt %); water is poorly soluble in the ketone (0.9 wt %). 5-Methyl-3-heptanone is highly soluble in common organic solvents.

Physical properties

Clear, colorless liquid with a mild, sweet, ether-like odor. Odor threshold concentration is 0.11 ppm (quoted, Amoore and Hautala, 1983).

Occurrence

Reported found in baked potato and wheaten bread.

Uses

2,6-Dimethyl-4-heptanone is used as a coating solvent. It is an active component of mint oil. It acts as a dispersant for organosol type resins. It is involved in the antigerminative treatment of bulbs and tubers. Further, it is used as a solvent for nitrocellulose. In addition to this, it acts as an intermediate in the preparation of inhibitors, active pharmaceutical ingredients and dyes.

Uses

Diisobutyl ketone (DIBK) is a transparent liquid with a distinct odor and a high boiling point. It is an heavy-end byproduct of producing MIBK. DIBK is used in many applications such as nitrocellulose lacquers, synthetic resins, coatings and stains, paint strippers, leather finishings, adhesives, printing and coating inks, cleaning and dregreasing, Flavors and fragrances, solvent and re-crystallization aid for pharmaceuticals, mining, and as a chemical intermediate. DIBK has good activity for many synthetic resins including nitrocellulose, rosin esters, phenolics, hydrocarbons, alkyds, polyesters, and acrylics. It is useful as a retarder solvent to improve flow and minimize humidity blushing. The low density and low surface tension of DIBK enables formulators to develop high-solids coatings with low VOC content and excellent flow and leveling properties. DIBK has excellent viscosity reduction for and reduces surface tension in high solid’s coatings. It has good volume-to-weight advantage over other classes of solvents used in coatings. It is a non-HAP (Hazardous Air Pollutant) solvent.

Uses

Diisobutyl ketone is used as a solvent fornitrocellulose, lacquers, and synthetic resins;in organic syntheses.

Uses

Diisobutyl Ketone is a component of mint oil and L-carvone solutions for fungicidal and antigerminative treatment of bulbs and tubers.

Definition

ChEBI: 2-Methyl-4-heptanone is a ketone.

Production Methods

Diisobutyl ketone is produced by hydrogenation of phorone or by metal-catalyzed decomposition of isovaleric acid.It is also a by-product in the manufacture of methyl isobutyl ketone.

Synthesis Reference(s)

Journal of the American Chemical Society, 95, p. 6876, 1973 DOI: 10.1021/ja00801a081

General Description

A clear colorless liquid. Flash point 140°F. Less dense than water and insoluble in water. Vapors heavier than air.

Air & Water Reactions

Flammable. Insoluble in water.

Reactivity Profile

2,6-Dimethyl-4-heptanone may attack some plastics. 2,6-Dimethyl-4-heptanone reacts with oxidizers.

Health Hazard

Inhalation of vapor causes irritation of nose and throat. Ingestion causes irritation of mouth and stomach. Vaporirritates eyes. Contact with liquid irritates skin.

Health Hazard

Inhalation of the vapors of diisobutyl ketonecan produce irritation of the eyes, nose, andthroat. At 25 ppm its odor was unpleasant, but the irritation effect on humanswas insignificant. At 50 ppm the irritationwas mild. A 7- hour exposure to 125 ppmhad no adverse effect on rats; however, at250 ppm, female rats developed increasedliver and kidney weights. An 8-hour exposure to 2000 ppm was lethal. Ingestion ofthis compound can cause the symptoms ofheadache, dizziness, and dermatitis.
LD50 value, oral (rats): 5.8 g/kg.

Flammability and Explosibility

Not classified

Chemical Reactivity

Reactivity with Water No reaction; Reactivity with Common Materials: May attack some forms of plastics; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Safety Profile

Moderately toxic by ingestion and inhalation. Mddly toxic by skin contact. Human systemic effects by inhalation: headache, nausea or vomiting, and unspecified eye effects. An eye and skin irritant. Narcotic in high concentrations. Flammable liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use Con, dry chemical, water spray, mist or fog. When heated to decomposition it emits acrid smoke and fumes. See also KETONES.

Potential Exposure

Human Data;Primary Irritant. Diisobutyl ketone is used as a solvent; as a dispersant for resins; and as an intermediate in the synthesisof pharmaceuticals and pesticides.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the

Environmental Fate

Biological. Using the BOD technique to measure biodegradation, the mean 5-d BOD value (mM BOD/mM diisobutyl ketone) and ThOD were 4.86 and 37.4%, respectively (Vaishnav et al., 1987).
Chemical/Physical. Diisobutyl ketone will not hydrolyze because it has no hydrolyzable functional group.
At an influent concentration of 300 mg/L, treatment with GAC resulted in nondetectable concentrations in the effluent. The adsorbability of the carbon used was 60 mg/g carbon (Guisti et al., 1974).

storage

Color Code—Red: Flammability Hazard: Store ina flammable liquid storage area or approved cabinet awayfrom ignition sources and corrosive and reactive materials. Prior to working with DIBK you should be trained on itsproper handling and storage. Before entering confined spacewhere DIBK may be present, check to make sure that anexplosive concentration does not exist. Store in tightlyclosed containers in a cool, well-ventilated area. Metal containers involving the transfer of this chemical should begrounded and bonded. Where possible, automatically pumpliquid from drums or other storage containers to processcontainers. Drums must be equipped with self-closingvalves, pressure vacuum bungs, and flame arresters. Useonly nonsparking tools and equipment, especially whenopening and closing containers of this chemical. Sources ofignition, such as smoking and open flames, are prohibitedwhere this chemical is used, handled, or stored in a mannerthat could create a potential fire or explosion hazard.Wherever this chemical is used, handled, manufactured, orstored, use explosion-proof electrical equipment andfittings.

Shipping

This compound requires a shipping label of“FLAMMABLE LIQUID.” It falls in Hazard Class 3 andPacking Group II.

Incompatibilities

Forms explosive mixture with air.Incompatible with strong acids, aliphatic amines, strongoxidizers. Attacks some forms of plastics, coatings, andrubber.

Waste Disposal

Incineration, molten metal salt destruction.

References

Bone, K. M., and W. D. Hibbert. "Solvent extraction with ammonium pyrrolidinedithiocarbamate and 2,6-dimethyl-4-heptanone for the determination of trace metals in effluents and natural waters." Analytica Chimica Acta 107.JUN(1979):219-229.
Miyazaki, Akira, A. Kimura, and Y. Umezaki. "Determination of ng ml-1 levels of phosphorus in waters by diisobutyl ketone extraction and inductively coupled plasma atomic emission spectrometry." Analytica Chimica Acta 127.96(1981):93-101.
Zhang, Fagen, et al. "Comparative metabolism and pharmacokinetics of diisobutyl ketone and diisobutyl carbinol in male SD rats." Toxicology Letters 232.1(2015):175-181.

2,6-Dimethyl-4-heptanone Preparation Products And Raw materials

Raw materials

2,6-Dimethyl-2,5-heptadien-4-one

Preparation Products

5-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID
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2,6-Dimethyl-4-heptanone Suppliers

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View Lastest Price from 2,6-Dimethyl-4-heptanone manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Diisobutyl ketone / 2,6-DIMETHYL-4-HEPTA 108-83-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-28
Hebei Chuanghai Biotechnology Co,.LTD
Product
2,6-Dimethyl-4-heptanone 108-83-8
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-15
Henan Bao Enluo International TradeCo.，LTD
Product
2,6-Dimethyl-4-heptanone 108-83-8
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500t/month
Release date
2023-08-09

108-83-8, 2,6-Dimethyl-4-heptanoneRelated Search:

DIISOBUTYLALUMINUM CHLORIDE ISOBUTYLTRICHLOROSILANE Dimethyl sulfate Dimethyl phthalate Dimethyl ether Dimethyl carbonate Dacthal Triisobutylaluminium 4-Methyl-2-pentanone Diisobutylaluminium hydride ETHANE Dimethyl disulfide Dimethyl sulfoxide Benzophenone N,N-Dimethylformamide Diisobutylcarbinol Dimethyl fumarate Cortisone acetate

  • 2,6-DIMETHYL-4-HEPTANONE
  • 2,6-Dimethyl-4-heptanone, remainder mainly 4,6-dimethyl-2-heptanone
  • Diisobutyl ketone~Isovalerone
  • Dimethylheptanone
  • 2 6-DIMETHYL-4-HEPTANONE 99+%
  • 2,6-DIMETHYL-4-HEPTANONE, TECH., 80%
  • 2,6-Dimethyl-4-Heptanone,Purified
  • 2,6-Dimethyl-4-heptanone, remainder mainly 4,6-dimethyl-2-heptanone, tech., 80%
  • isovaleron
  • VALERONE
  • S-DIISOPROPYLACETONE
  • 2,6-dimetil-eptan-4-one (italian)
  • 2,6-DIMETHYL-4-HEPTANONE,98+%
  • 2,6-DIMETHYL-4-HEPTANONE, MIXTURE OF ISOMERS, 98%, CA 2:1 WI
  • 2,6-Dimethyl-4-heptanone, mixture of isomers, 98%, ca 2:1 with 4,6-dimethyl-2-heptanone
  • 2,6-DIMETHYL-4-HEPTANONE, PURE
  • 2,6-dimethylheptan-4-one di-isobutyl ketone
  • Di Isobutyl Ketone (DIBK)
  • DIBK, Diisobutyl ketone, Isovalerone
  • ISOVALERONE
  • DIISOBUTYL KETONE
  • DIBK
  • ISOBUTYL KETONE
  • FEMA 3537
  • (iso-C4H9)2CO
  • 2,5-Dimethyl-4-heptanone
  • 2,6-dimethyl-4-heptanon
  • 2,6-dimethyl-4-heptanone (diisobutyl ketone)
  • 2,6-Dimethyl-heptan-4-on
  • 2,6-Dimethylheptan-4-on
  • 2,6-dimethyl-heptan-4-on(dutch,german)
  • 2,6-dimethyl-heptan-4-one
  • 2,6-Dimethylheptan-4-one
  • 2,6-Dimetil-eptan-4-one
  • 4-Heptanone,2,6-dimethyl-
  • dibutylketone(non-specificname)
  • Diisobutilchetone
  • DiMethyl-4-heptan
  • 2,6-Dimethyi-4-heptanone
  • Diisobutyl ketone for synthesis
  • 2,6-Dimethyl-4-heptanone, (sum of 2,6-Dimethyl-4-heptanone & 4,6-Dimethyl-2-heptanone)
  • diisobutylcetone
  • Di-isobutylcetone
  • di-isobutylcetone(french)
  • Diisobutylketon
  • diisobutylketon(dutch,german)
  • Diisopropylacetone
  • sec-diisopropylacetone
  • sym-Diisopropylacetone
  • 2,6-Dimethyl-4-heptanone technical grade
  • 2,6-Dimethyl-4-heptanone, 80%, remainder mainly 4,6-dimethyl-2-heptanone, tech.
  • Diisobutyl ketone, extra pure
  • 2,6-Dimethyl-4-heptanone,Diisobutyl ketone, Isovalerone
  • 2,6-2-4-heptanone
  • 2,6-DiMethyl-4-heptanone, >90% (suM of 2,6-DiMethyl-4-heptanone & 4,6-DiMethyl-4-heptanone)
  • 2,6-DiMethyl-4-heptanone, >90% (suM of 2,6-DiMethyl-4-heptanone & 4,6-DiMethyl-2-heptanone)
  • 2,6-Dimethyl-4-heptanone, mixture of isomers, 97%, ca 2:1 with 4,6-dimethyl-2-heptanone
  • NSC 15136