(R)-(-)-2-Aminobutane Property

Melting point:

-105°C

alpha 

-7.5 º (c=neat 19 ºC)

Boiling point:

63 °C(lit.)

Density 

0.72 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.393(lit.)

Flash point:

-19°C

storage temp. 

Flammables area

pka

10.74±0.10(Predicted)

form 

clear liquid

color 

Colorless to Almost colorless

optical activity

[α]19/D 7.5°, neat

Water Solubility 

> 10 mg/L

Sensitive 

Air Sensitive

Merck 

14,1544

BRN 

1718760

CAS DataBase Reference

13250-12-9(CAS DataBase Reference)

Safety

Hazard Codes 

F,C,N,F+

Risk Statements 

11-34-50-35-20/22

Safety Statements 

16-26-36/37/39-45-9-61-28A-28

RIDADR 

UN 2733 3/PG 2

WGK Germany 

3

F 

10-23

HazardClass 

3

PackingGroup 

II

HS Code 

29211999

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H314Causes severe skin burns and eye damage

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

(R)-(-)-2-Aminobutane Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liqui

Uses

(R)-(-)-2-Aminobutane is a chiral amine plays an important role in pharmaceutical chemistry and in organic synthesis as chiral auxiliary, which is used to determine the enantiomeric excess (ee).

Uses

(R)-(?)-sec-Butylamine can be used:

• To prepare (R)-(?)-sec-butylbis(2-hydroxyethyl)amine, an intermediate for the synthesis of aminodiphosphine ligands.
• As a substrate to demonstrate the stereochemistry of Mitsunobu reaction in the synthesis of secondary amines.
• As a model compound in the study of singlet-triplet transitions in circular dichroism.

Purification Methods

Dry it over solid NaOH overnight and fractionate it through a short helices packed column. The L-hydrogen tartrate salt has m 139-140o (from H2O), the 1H2O has m 96o []D +18.1o (c 11, H2O), the hydrochloride has m 152o [ ] 21 -1.1o (c 13, H2O) and the benzoyl derivative crystallises from EtOH as needles with m 97o, [] 21 -34.9o (c 11, H2O). [Bruck et al. J Chem Soc 921 1956,Kjaer & Hansen Acta Chem Scand 11 898 1957.] [Beilstein 4 H 161, 4 I 372, 4 III 308, 4 IV 617.] The S -(+)-enantiomer has has same properties except for the optical rotation which has the opposite sign.