ChemicalBook > CAS DataBase List > 7-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

7-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

Product Name
7-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine
CAS No.
34950-82-8
Chemical Name
7-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine
Synonyms
7-bromo-2H,3H,4H-pyrido[3,2-b][1,4]oxazine;7-bromo-3,4-dihydro-2H-pyrido[3,2-β][1,4]oxazine;7-BROMO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE;2H-Pyrido[3,2-b]-1,4-oxazine, 7-bromo-3,4-dihydro-
CBNumber
CB8853534
Molecular Formula
C7H7BrN2O
Formula Weight
215.05
MOL File
34950-82-8.mol
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7-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine Property

Melting point:
116 °C
Boiling point:
316.8±42.0 °C(Predicted)
Density 
1.619±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
7.32±0.20(Predicted)
form 
solid
Appearance
Light yellow to green yellow Solid
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Safety

WGK Germany 
3
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
ADE001250
Product name
7-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine
Purity
Aldrich
Packaging
1g
Price
$817
Updated
2025/07/31
TRC
Product number
B699683
Product name
7-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
B699683
Product name
7-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
B699683
Product name
7-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine
Packaging
500mg
Price
$130
Updated
2021/12/16
Matrix Scientific
Product number
048483
Product name
7-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine
Packaging
250mg
Price
$342
Updated
2021/12/16
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7-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine Chemical Properties,Usage,Production

Synthesis

20348-23-6

34950-82-8

3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine (500 mg, 3.67 mmol) was used as starting material and dissolved in DMF (10 mL). To this solution was added N-bromosuccinimide (NBS, 719 mg, 4.04 mmol) at 0 °C. The reaction mixture was stirred continuously for 2 h at 0 °C. Upon completion of the reaction, the reaction was quenched with saturated aqueous NaHCO3 solution and stirring was continued for 20 min at 0 °C. The resulting precipitate was collected by filtration and the solid product was washed with water and dried under vacuum to afford 7-bromo-3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazine (549 mg, 2.55 mmol, 69.5% yield) as a brown solid. The product was analyzed by mass spectrometry (ESI+) with a measured value of 215.2 (M + H).1H NMR (300 MHz, CDCl3) δ: 3.50-3.58 (2H, m), 4.18-4.26 (2H, m), 4.82 (1H, brs), 7.10 (1H, d, J = 1.9 Hz), 7.72 (1H, d, J = 2.3 Hz).

References

[1] Patent: WO2018/30550, 2018, A1. Location in patent: Paragraph 0596
[2] Patent: EP2341052, 2011, A1. Location in patent: Page/Page column 40
[3] Acta Chemica Scandinavica (1947-1973), 1971, vol. 25, p. 3135 - 3143
[4] Patent: KR101576386, 2015, B1. Location in patent: Paragraph 0158-0160

7-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 7-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
7-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine 34950-82-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-08-08

34950-82-8, 7-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazineRelated Search:


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  • 7-BROMO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE
  • 7-bromo-3,4-dihydro-2H-pyrido[3,2-β][1,4]oxazine
  • 2H-Pyrido[3,2-b]-1,4-oxazine, 7-bromo-3,4-dihydro-
  • 34950-82-8