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fenspiride

Product Name
fenspiride
CAS No.
5053-06-5
Chemical Name
fenspiride
Synonyms
DESP;FUBMN24;FUB-MN24;Fenspirid;fenspiride;Fenspiridum;Fenspiride-d5;fenspiride USP/EP/BP;8-phenethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one;Pharmaceutical intermediates BKEDBP BKEDBP bkedbp
CBNumber
CB8875352
Molecular Formula
C15H20N2O2
Formula Weight
260.33
MOL File
5053-06-5.mol
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fenspiride Property

Boiling point:
126-127 °C(Press: 2 Torr)
Density 
1.19±0.1 g/cm3(Predicted)
pka
12.44±0.20(Predicted)
form 
Solid:particulate/powder
color 
White to off-white
LogP
1.798-1.802 at 20℃ and pH6
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific
Product number
S040
Product name
Fenspiride
Packaging
1g
Price
$384
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
RDL0006831
Product name
FENSPIRIDE-D5
Purity
95.00%
Packaging
5MG
Price
$500.31
Updated
2021/12/16
AK Scientific
Product number
S040
Product name
Fenspiride
Packaging
5g
Price
$1051
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
D74913
Product name
Fenspiride-d5
Packaging
5mg
Price
$1490
Updated
2021/12/16
J&W Pharmlab
Product number
60R0505
Product name
8-Phenethyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one
Purity
97%
Packaging
5g
Price
$3998
Updated
2021/12/16
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fenspiride Chemical Properties,Usage,Production

Originator

Viarespan,Servier,France,1969

Uses

Bronchodilator;anti-adrenergic (β-receptor).

Definition

ChEBI: 8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one is an azaspiro compound.

Manufacturing Process

A solution of 192 g of 1-phenethyl-4-hydroxy-4-aminomethyl piperidine in 800 cc of diethylcarbonate is heated for 2? hours to reflux at about 80°C in the presence of sodium methylate (prepared for immediate use from 2 g of sodium). After this time, the ethyl alcohol formed during the reaction is slowly distilled while the maximum temperature is reached. The excess ethyl carbonate is distilled under reduced pressure. A crystallized residue is then obtained, which is stirred with 400 cc of water and 400 cc of ether. The solution is filtered and 125 g (77.6%) of practically pure product melting at 232°C to 233°C, are obtained.
The starting material was prepared in a yield of 58% by reduction of the corresponding cyanohydrin. It in turn was prepared from 1-(2-phenylethyl)-4- piperidone and potassium cyanide to give the cyanohydrin which was reduced by lithium aluminum hydride.

Therapeutic Function

Bronchodilator

Pharmaceutical Applications

Fenspiride is an antagonist of 5-hydroxytryptamine, whose effect on bronchial smooth muscle expansion is between isoproterenol and theophylline. It also has the effect of unobtrusion-free respiratory tract and air resistance elimination in the lungs. It has the effect of antitussive, antipyretic, analgesic and anti-inflammatory, and the antipyretic and analgesic effect is better than aminopyrine and the anti-inflammatory effect is stronger than bute.

fenspiride Preparation Products And Raw materials

Raw materials

Preparation Products

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fenspiride Suppliers

Sinbond Industiral Co., Ltd.
Tel
--
Fax
--
Email
cici1124@gmail.com
Country
United Kingdom
ProdList
248
Advantage
50
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View Lastest Price from fenspiride manufacturers

Henan Bao Enluo International TradeCo.,LTD
Product
Fenspiride 5053-06-5
Price
US $50.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
10000MT
Release date
2023-06-28
Qiuxian Baitai New Material Co., LTD
Product
fenspiride 5053-06-5
Price
US $25.00/KG
Min. Order
100g
Purity
99.99%
Supply Ability
5ton/Month
Release date
2021-11-24
Wuhan Monad Medicine Tech Co.,LTD
Product
Fenspiride 5053-06-5
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%min
Supply Ability
5000
Release date
2021-04-16

5053-06-5, fenspirideRelated Search:


  • fenspiride
  • Fenspiridum
  • 8-phenethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one
  • 8-(2-Phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one
  • DESP
  • Fenspirid
  • 1-Oxa-3,8-diazaspiro[4.5]decan-2-one, 8-(2-phenylethyl)-
  • Fenspiride-d5
  • Pharmaceutical intermediates BKEDBP BKEDBP bkedbp
  • FUBMN24
  • FUB-MN24
  • fenspiride USP/EP/BP
  • 5053-06-5
  • 5053-6-5
  • 5053-38-7
  • 5053/6/5
  • 5053-06-6
  • Intermediate
  • medical intermediate
  • Pharm intermediate
  • organic
  • Pharmaceutical intermediates