Varenicline tartrate

Product Name: Varenicline tartrate
CAS No.: 375815-87-5
Chemical Name: Varenicline tartrate
Synonyms: CS-291;Champix;Pidifix330;Pidifix-330;CP 526555-18;Unii-82269asb48;ChaMpix tartrate;Chantix tartrate;Varniclan tartrate;Varenicline tatrate
CBNumber: CB91011765
Molecular Formula: C17H19N3O6
Formula Weight: 361.35
MOL File: 375815-87-5.mol

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Varenicline tartrate Property

Melting point:: 206-208°C
storage temp.: room temp
solubility: DMSO: >5mg/mL
form: powder
color: white to beige
Stability:: Hygroscopic
InChI: InChI=1/C13H13N3.C4H6O6/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1;5-1(3(7)8)2(6)4(9)10/h1-2,4-5,8-9,14H,3,6-7H2;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/s3
InChIKey: TWYFGYXQSYOKLK-UHFFFAOYSA-N
SMILES: [C@H](O)(C(=O)O)[C@@H](O)C(=O)O.C12=CC3=NC=CN=C3C=C1C1CNCC2C1 |&1:0,5,r|

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Safety

Hazard Codes: Xn,N,T,F
Risk Statements: 22-50-39/23/24/25-23/24/25-11
Safety Statements: 22-57-45-36/37-16-7
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0004
Product name: Varenicline tartrate
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $149
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0004
Product name: Varenicline tartrate
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $591
Updated: 2024/03/01

Cayman Chemical

Product number: 15030
Product name: Varenicline (tartrate)
Purity: ≥98%
Packaging: 5mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 15030
Product name: Varenicline (tartrate)
Purity: ≥98%
Packaging: 10mg
Price: $198
Updated: 2024/03/01

Cayman Chemical

Product number: 15030
Product name: Varenicline (tartrate)
Purity: ≥98%
Packaging: 25mg
Price: $467
Updated: 2024/03/01

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Varenicline tartrate Chemical Properties,Usage,Production

Chemical Properties

Tan Solid

Uses

Nicotinic a4? acetylcholine receptor partial agonist. Aid in smoking cessation.

Uses

Varenicline tartrate is a prescription medication used to treat smoking addiction. Varenicline is a nicotinic receptor partial agonist. In this respect, it is similar to cytisine and different from the nicotinic antagonist, bupropion, and nicotine replacement ther

Uses

Nicotinic α4β2 acetylcholine receptor partial agonist. Aid in smoking cessation.

Definition

ChEBI: A tartrate salt obtained by reaction of varenicline with one equivalent of (R,R)-tartaric acid. A partial agonist for nicotinic cholinergic receptors, it is used as an aid to giving up smoking.

brand name

Chantix (Pfizer).

Biological Activity

Orally active, subtype-selective partial agonist at α 4 β 2 nicotinic receptors (K i values are 0.06, 240, 322 and 3540 nM for α 4 β 2, α 3 β 4, α 7, α 1 β γ δ receptors respectively). Reduces nicotine-evoked dopamine release in vitro and decreases nicotine self-administration in vivo .

Biochem/physiol Actions

Varenicline tartrate is a partial α4β2 nicotinic receptor agonist and α7 full agonist. Varenicline competitively binds to α4β2 receptors and partially stimulates without creating a full nicotine effect, while simultaneoudly blocking the ability of nicotine to bind to the receptors. Varenicline thus blocks the ability of nicotine to activate α4β2 receptors and stimulate the central nervous mesolimbic dopamine system, believed to be the neuronal mechanism underlying reinforcement and reward experienced upon smoking.

storage

Room temperature

Varenicline tartrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Varenicline tartrate Suppliers

Canada 2 China 247 India 36 Japan 1 United Kingdom 4 United States 27 Global 317

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View Lastest Price from Varenicline tartrate manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Varenicline tartrate 375815-87-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-01

Hebei Yanxi Chemical Co., Ltd.

Product: Varenicline tartrate 375815-87-5
Price: US $30.00-10.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-11-16

Hangzhou ICH Biofarm Co., Ltd

Product: Varenicline tartrate 375815-87-5
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 99.0%min
Supply Ability: 200kg
Release date: 2023-06-09

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VARENICLINE TARTRATE

Varenicline tartrate for research

7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine (2R,3R)-2,3- dihydroxybutanedioate

Champix

CP 526555-18

Varenicline Tartarate

CS-291

,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 7,8,9,10-tetrahydro-

7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepinetartrate

6,10-Methano-6H-pyrazino(2,3-H)(3)benzazepine, 7,8,9,10-tetrahydro-, (2R,3R)-2,3-dihydroxybutanedioate (1:1)

Unii-82269asb48

7,8,9,10-Tetrahydro-

ChaMpix tartrate

Chantix tartrate

Varenicline tatrate

6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 7,8,9,10-tetrahydro-, (2R,3R)-2,3-dihydroxybutanedioate

Varenicline tartrate solution

7,8,9,10-Tetrahydro-6H-6,10-methanoazepino-[4,5-g]quinoxaline (2R,3R)-2,3-dihydroxysuccinate

7,8,9,10-Tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline (2R,3R)-2,3-Dihydroxysuccinic Acid

Varenicline tartrate USP/EP/BP

Varenicline Tartrate DISCONTINUED

Varenicline Tartrate (CP 526555-18)

Pidifix330

Pidifix-330

TLF3617 Pidifix 330

Varniclan tartrate

Vernicline Tartrate API

375815-87-5

75815-87-5

C13H13N3C4H6O6

Heterocycles

Intermediates & Fine Chemicals

Heterocyclic Compounds

Inhibitors

Chantix, Champix

APIs

Pfizer compounds

Pharmaceuticals