4,5,6,7-TETRABROMOBENZOTRIAZOLE

Product Name: 4,5,6,7-TETRABROMOBENZOTRIAZOLE
CAS No.: 17374-26-4
Chemical Name: 4,5,6,7-TETRABROMOBENZOTRIAZOLE
Synonyms: TBB;TBBT;NSC 231634;7-tetrabromo-;CK2 INHIBITOR;TBB(NSC 231634);YM905 free base;TBB (enzyMe inhibitor);4,5,6,7-Tetrabromotriazole;CASEIN KINASE II INHIBITOR I
CBNumber: CB9104424
Molecular Formula: C6HBr4N3
Formula Weight: 434.71
MOL File: 17374-26-4.mol

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4,5,6,7-TETRABROMOBENZOTRIAZOLE Property

Melting point:: 262-266°C
Boiling point:: 552.5±45.0 °C(Predicted)
Density: 2.840±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 28 mg/mL
pka: 3.87±0.40(Predicted)
form: solid
color: white
λmax: 300nm(MeOH)(lit.)

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Safety

WGK Germany: 3
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T0826
Product name: TBB
Purity: ≥98% (HPLC), solid
Packaging: 10mg
Price: $282
Updated: 2024/03/01

Sigma-Aldrich

Product number: 218697
Product name: Casein Kinase II Inhibitor I
Packaging: 10mg
Price: $144
Updated: 2024/03/01

TCI Chemical

Product number: T2920
Product name: 4,5,6,7-Tetrabromobenzotriazole
Purity: >97.0%(HPLC)(T)
Packaging: 10mg
Price: $103
Updated: 2022/04/27

TCI Chemical

Product number: T2920
Product name: 4,5,6,7-Tetrabromobenzotriazole
Purity: >97.0%(HPLC)(T)
Packaging: 50mg
Price: $373
Updated: 2024/03/01

Cayman Chemical

Product number: 14453
Product name: TBB
Purity: ≥98%
Packaging: 5mg
Price: $38
Updated: 2024/03/01

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4,5,6,7-TETRABROMOBENZOTRIAZOLE Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Uses

TBB is one of the most selective protein kinase inhibitors known, and when tested against a panel of 33 serine/threonine and tyrosine protein kinases, only three exhibited moderate inhibition by TBB, with Ki values one to two orders of magnitude higher than that for CK2.

Biological Activity

A cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC 50 = 0.9 and 1.6 μ M for rat liver and human recombinant CK2 respectively). Exhibits modest discrimination between CK2 subunits, with K i values ranging from 80 nM to 210 nM. Acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases.

Biochem/physiol Actions

TBB binds to the Val66 residue of casein kinase-2 and inhibits the binding of ATP/GTP. TBB is cell permeable; it induces caspase-dependent apoptosis and degrades hematopoietic lineage cell-specific protein 1 in Jurkat cells.

storage

Store at -20°C

4,5,6,7-TETRABROMOBENZOTRIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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4,5,6,7-TETRABROMOBENZOTRIAZOLE Suppliers

Canada 1 China 91 Europe 1 France 1 Germany 3 India 3 Japan 1 Switzerland 1 United Kingdom 1 United States 19 Global 122

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View Lastest Price from 4,5,6,7-TETRABROMOBENZOTRIAZOLE manufacturers

Career Henan Chemical Co

Product: 4,5,6,7-TETRABROMOBENZOTRIAZOLE 17374-26-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 500kg/month
Release date: 2019-08-01

17374-26-4, 4,5,6,7-TETRABROMOBENZOTRIAZOLERelated Search:

2-(2H-Benzothiazol-2-yl)-6-(dodecyl)-4-methylphenol Dibenzothiophene Centchroman CASEIN KINASE II 5-BROMO-1H-BENZOTRIAZOLE 4,5,6,7-TETRABROMOBENZOTRIAZOLE

NSC 231634

TBB

TBBT

7-tetrabromo-

NSC 231634; TBB (ENZYME INHIBITOR);1H-BENZOTRIAZOLE; 4;5;6;7-TETRABROMO-

4,5,6,7-Tetrabromo-1H-benzotriazole

CASEIN KINASE II INHIBITOR *TBB**

4,5,6,7-Tetrabromo-2-azabenzimidazole, 4,5,6,7-Tetrabromobenzotriazole, NSC 231634, TBBt

1H-Benzotriazole, 4,5,6,7-tetrabroMo-

TBB (enzyMe inhibitor)

4,5,6,7-TetrabroMo-1H-benzo[d][1,2,3]triazole

TBB(NSC 231634)

4,5,6,7-tetrabromo-2H-benzotriazole

4,5,6,7-Tetrabromobenzotriazole, 97%, selective, cell-permeable casein kinase-2 (CK2) inhibitor

4,5,6,7-TETRABROMO-2-AZABENZIMIDAZOLE

4,5,6,7-TETRABROMOBENZOTRIAZOLE

CASEIN KINASE II INHIBITOR I

CK2 INHIBITOR

4,5,6,7-Tetrabromotriazole

YM905 free base

4,5,6,7-Tetrabromobenzotriazole, selective, cell-permeable casein kinase-2 (CK2) inhibitor

17374-26-4

35-95-2

C6HN3Br4

C6HBr4N3

Casein Kinase (CK)

Cell Biology

Cell Signaling and Neuroscience

BioChemical

Kinase/Phosphatase Biology

Serine/Threonine Kinase Inhibitors

Akt

mTOR

PI3K

Inhibitors

PI3K/Akt/mTOR

Protein Kinase

Protein Kinase Inhibitors and Activators