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Isothiazole

Product Name
Isothiazole
CAS No.
288-16-4
Chemical Name
Isothiazole
Synonyms
EOS-61208;1,2-Thiazol;Isothiazole;1,2-thiazole;2-Azathiophene;Isothiazole>288-16-4 Isothiazole;Isothiazole (6CI, 7CI, 8CI, 9CI, ACI)
CBNumber
CB91074072
Molecular Formula
C3H3NS
Formula Weight
85.13
MOL File
288-16-4.mol
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Isothiazole Property

Melting point:
176 °C (decomp)(Solv: water (7732-18-5))
Boiling point:
114°C(lit.)
Density 
1.1566 (rough estimate)
refractive index 
1.5280 to 1.5320
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Chloroform, Ethyl Acetate
form 
Oil
pka
4.00±0.12(Predicted)
color 
Clear Colourless
λmax
242nm(lit.)
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Safety

RIDADR 
UN 1993 3/PG II
HS Code 
2934.10.2000
HazardClass 
3
PackingGroup 
II
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
I0982
Product name
Isothiazole
Purity
>98.0%(GC)
Packaging
200mg
Price
$50
Updated
2024/03/01
TCI Chemical
Product number
I0982
Product name
Isothiazole
Purity
>98.0%(GC)
Packaging
1g
Price
$147
Updated
2024/03/01
TRC
Product number
I917605
Product name
Isothiazole
Packaging
500mg
Price
$130
Updated
2021/12/16
Matrix Scientific
Product number
133212
Product name
Isothiazole
Purity
97%
Packaging
10g
Price
$1296
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
65704
Product name
Isothiazole
Packaging
5G
Price
$2000
Updated
2021/12/16
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Isothiazole Chemical Properties,Usage,Production

Chemical Properties

Isothiazole is a colorless liquid with a pyridine-like odor. It is only slightly soluble in water but readily dissolves in organic solvents such as ethanol and benzene. When treated with butyl lithium at -70°C, it undergoes lithiation at the 5-position. Isothiazole serves as a versatile intermediate for the synthesis of various 5-substituted derivatives, including alkyl groups (R-), formyl (-CHO), carboxyl (-COOH), and acyl groups (RCO-), among others. Electrophilic substitution reactions, such as nitration, sulfonation, and halogenation, predominantly occur at the 4-position.

Uses

Isothiazole, is a versatile building block that can be used in the synthesis of more complex compounds with biological activity such as the pharmaceutical drugs ziprasidone (Z485000), and perospirone (P288900).

Definition

ChEBI: Isothiazole is a mancude organic heteromonocyclic parent, a monocyclic heteroarene and a member of 1,2-thiazoles.

Preparation

Isothiazole can be prepared by the reaction of propiolic aldehyde with sodium thiocyanate to first produce 3-thiocyanatoacrolein (NCSCH=CHCHO), which is then reacted with ammonia to obtain isothiazole.

References

[1] LAI CHEN. Discovery of Novel Isothiazole, 1,2,3-Thiadiazole, and Thiazole-Based Cinnamamides as Fungicidal Candidates[J]. Journal of Agricultural and Food Chemistry, 2019, 67 45: 12357-12365. DOI:10.1021/acs.jafc.9b03891.
[2] A. KLETSKOV. Isothiazoles in the Design and Synthesis of Biologically Active Substances and Ligands for Metal Complexes[J]. Synthesis-Stuttgart, 2019, 113 1: 159-188. DOI:10.1055/s-0039-1690688.
[3] BERA A, PATRA P, AZAD A, et al. Neat synthesis of isothiazole compounds, and studies on their synthetic applications and photophysical properties?[J]. New Journal of Chemistry, 2022, 24: 11685-11694. DOI:10.1039/D2NJ01962K.
[4] ZHU-ZHU ZHANG. Synthesis of Isoselenazoles and Isothiazoles from Demethoxylative Cycloaddition of Alkynyl Oxime Ethers[J]. The Journal of Organic Chemistry, 2020, 86 1: 632-642. DOI:10.1021/acs.joc.0c02286.

Isothiazole Preparation Products And Raw materials

Raw materials

Preparation Products

corrosion inhibitor PBTCA-type Disperse Blue 148
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Isothiazole Suppliers

Americas 1 China 117 Europe 1 Germany 1 India 3 Japan 1 United States 14 Global 138
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
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001-617-206-9595
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sales@chemreagents.com
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United States
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Alchem Pharmtech,Inc.
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8485655694
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sales@alchempharmtech.com
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United States
ProdList
63687
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58
Aladdin Scientific
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+1-+1(833)-552-7181
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sales@aladdinsci.com
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United States
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57505
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58
Synthonix Inc
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United States
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AstaTech, Inc
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Focus Synthesis LLC
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Alichem Inc.
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Oakwood Products, Inc.
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OChem Incorporation
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United States Biological
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Combi-Blocks Inc.
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TCI America
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Matrix Scientific
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Allweys LLC
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View Lastest Price from Isothiazole manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
Isothiazole 288-16-4
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000
Release date
2024-03-26
Hebei Weibang Biotechnology Co., Ltd
Product
Isothiazole 288-16-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-30
Hebei Mujin Biotechnology Co.,Ltd
Product
Isothiazole 288-16-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-11-23

288-16-4, IsothiazoleRelated Search:

2-Methyl-4-isothiazolin-3-one Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Isothiazolo[5,4-b]pyridin-3-amine thiazol-3-one Isothiazolo[5,4-b]pyridin-3(2H)-one, 1,1-dioxide ISOTHIAZOLE-5-BORONIC ACID 1,1-DIOXO-ISOTHIAZOLIDINE-3-CARBOXYLIC ACID Isothiazolo[5,4-b]pyridin-3-ol 4-Isothiazolecarbonitrile 3-Aminoisothiazolo[4,3-b]pyridine ISOTHIAZOLINE 1,1-DIOXIDE 4-Carboxyisothiazole Isothiazol-4-ylMethanaMine 3-Isothiazolecarboxamide isothiazol-3-ylMethanol 5-ISOTHIAZOLECARBOXYLIC ACID ISOTHIAZOLE-5-CARBALDEHYDE Isothiazole-5-methanol

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  • EOS-61208
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  • 1,2-Thiazol
  • 288-16-4 Isothiazole
  • Isothiazole (6CI, 7CI, 8CI, 9CI, ACI)
  • 288-16-4
  • Pharmaceutical raw material