ISOTHIAZOLINE 1,1-DIOXIDE

Product Name: ISOTHIAZOLINE 1,1-DIOXIDE
CAS No.: 5908-62-3
Chemical Name: ISOTHIAZOLINE 1,1-DIOXIDE
Synonyms: IsothiazoL;idine 1,1-dioxide;ISOTHIAZOLINE 1,1-DIOXIDE;1,2-thiazolidine-1,1-dione;1,2-thiazolidine 1,1-dioxide;ISOTHIAZOLINE 1,1-DIOXIDE, 10 mM in DMSO;ISOTHIAZOLINE 1,1 DIOXIDE,ISOTHIAZOLINE 1,1DIOXIDE
CBNumber: CB51502322
Molecular Formula: C3H7NO2S
Formula Weight: 121.16
MOL File: 5908-62-3.mol

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ISOTHIAZOLINE 1,1-DIOXIDE Property

Melting point:: 145-146 °C
Boiling point:: 128-132 °C(Press: 0.18 Torr)
Density: 1.326±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 11.52±0.20(Predicted)
form: liquid
color: Colorless to light yellow
InChI: InChI=1S/C3H7NO2S/c5-7(6)3-1-2-4-7/h4H,1-3H2
InChIKey: XGYCWCIGCYGQFU-UHFFFAOYSA-N
SMILES: S1(=O)(=O)CCCN1

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Safety

WGK Germany: 3
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: P835288
Product name: PropaneSultam
Packaging: 100mg
Price: $85
Updated: 2021/12/16

ChemScene

Product number: CS-W001194
Product name: 1,1-Dioxoisothiazolidine
Purity: ≥98.0%
Packaging: 1g
Price: $104
Updated: 2021/12/16

Apolloscientific

Product number: OR914517
Product name: 1,2-Thiazolidine1,1-dioxide
Purity: 98%
Packaging: 1g
Price: $105
Updated: 2021/12/16

AK Scientific

Product number: W7199
Product name: 1,3-Propanesultam
Packaging: 1g
Price: $177
Updated: 2021/12/16

Matrix Scientific

Product number: 123074
Product name: 1,3-Propanesultam
Purity: 95+%
Packaging: 1g
Price: $396
Updated: 2021/12/16

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ISOTHIAZOLINE 1,1-DIOXIDE Chemical Properties,Usage,Production

Uses

Propane Sultam is a reactant used in the synthesis of orally bioavailable hebatits B caspid inhibitors as well as in the preparation of cryptochrome imhibitors as antidiabetic agents.

Synthesis

35578-28-0

5908-62-3

At room temperature, 3-chloropropane-1-sulfonamide (27 g, 170 mmol, 1 eq.) was dissolved in ethanol (250 ml), followed by addition of sodium ethoxide (11.7 g, 170 mmol, 1 eq.). The reaction mixture was heated to reflux for 5 h. After completion of the reaction it was cooled to room temperature and concentrated under reduced pressure. The residual solid was fully extracted with dichloromethane, the organic phases were combined and concentrated under reduced pressure to give 1,1-dioxoisothiazolidine (20 g, 100% yield).

References

[1] Patent: WO2004/50619, 2004, A1. Location in patent: Page 24
[2] Journal of the American Chemical Society, 2015, vol. 137, # 17, p. 5638 - 5641
[3] Journal of Organic Chemistry, 1987, vol. 52, # 11, p. 2162 - 2166
[4] Patent: WO2012/3283, 2012, A1. Location in patent: Page/Page column 206-207
[5] Patent: US2012/316147, 2012, A1. Location in patent: Page/Page column 62-63

ISOTHIAZOLINE 1,1-DIOXIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ISOTHIAZOLINE 1,1-DIOXIDE Suppliers

China 73 France 1 India 1 Ukraine 2 United States 14 Global 91

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View Lastest Price from ISOTHIAZOLINE 1,1-DIOXIDE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1,3-Propanesultam 5908-62-3
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

5908-62-3, ISOTHIAZOLINE 1,1-DIOXIDERelated Search:

Isothiazole-5-methanol 3-Aminoisothiazolo[4,3-b]pyridine Isothiazole Isothiazole-4-carbaldehyde (2R)-Bornane-10,2-sultam (1R)-(-)-(10-Camphorsulfonyl)oxaziridine (+)-(8,8-DICHLOROCAMPHORYLSULFONYL)OXAZIRIDINE (2S)-Bornane-10,2-sultam (1S)-(+)-(Camphorylsulfonyl)oxaziridine N-(2-CARBOXYBENZOYL)-(-)-10,2-CAMPHORSULTAM N-(2-CARBOXY-4,5-DICHLOROBENZOYL)-(-)-10,2-CAMPHORSULTAM N-(2-CARBOXY-4,5-DICHLOROBENZOYL)-(+)-10,2-CAMPHORSULTAM (2R)-BORNANE-10,2-SULTAM GLYCINATE N-PROPIONYL-(2R)-BORNANE- 10,2-SULTAM N-ACETYL-(2S)-BORNANE 10,2-SULTAM (S)-(+)-(2-BUTENOYL)-2 10-CAMPHORSULTAM (2S)-BORNANE-10,2-SULTAM GLYCINATE N-PROPIONYL-(2S)-BORNANE- 10,2-SULTAM

ISOTHIAZOLINE 1,1-DIOXIDE

1,2-thiazolidine-1,1-dione

1,2-thiazolidine 1,1-dioxide

idine 1,1-dioxide

IsothiazoL

ISOTHIAZOLINE 1,1 DIOXIDE,ISOTHIAZOLINE 1,1DIOXIDE

ISOTHIAZOLINE 1,1-DIOXIDE, 10 mM in DMSO

5908-62-3