Betulonicacid
- Product Name
- Betulonicacid
- CAS No.
- 4481-62-3
- Chemical Name
- Betulonicacid
- Synonyms
- Prazocin;Prazosine;LiquidaMba;Betulonicaci;Betunolic acid;Betulonic acid;Lulu Tong acid;Betulinonic acid;Betulonic Acid(P);Betulonic acid-RM
- CBNumber
- CB91075473
- Molecular Formula
- C30H46O3
- Formula Weight
- 454.68
- MOL File
- 4481-62-3.mol
Betulonicacid Property
- Melting point:
- 253 °C
- Boiling point:
- 548.1±33.0 °C(Predicted)
- Density
- 1.061±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- Solid
- pka
- 4.62±0.70(Predicted)
- color
- White to Off-White
- InChIKey
- SLJTWDNVZKIDAU-SVAFSPIFSA-N
- SMILES
- C1(=O)[C@@]([C@]2([C@](C)(CC1)[C@]1([H])[C@@]([C@]3([C@@](CC1)([H])[C@@]1([C@@](CC[C@H]1C(C)=C)(C(O)=O)CC3)[H])C)(C)CC2)[H])(C)C
Safety
- Safety Statements
- 24/25
- HS Code
- 29389090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H227Combustible liquid
H290May be corrosive to metals
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P234Keep only in original container.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363Wash contaminated clothing before reuse.
P370+P378In case of fire: Use … for extinction.
P390Absorb spillage to prevent material damage.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P406Store in corrosive resistant/… container with a resistant inner liner.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PHL83839
- Product name
- Betulonic acid
- Purity
- phyproof? Reference Substance
- Packaging
- 10MG
- Price
- $363
- Updated
- 2025/07/31
- Product number
- B6085
- Product name
- Betulonic Acid
- Packaging
- 50MG
- Price
- $177
- Updated
- 2025/07/31
- Product number
- B6085
- Product name
- Betulonic Acid
- Packaging
- 250MG
- Price
- $619
- Updated
- 2025/07/31
- Product number
- 29765
- Product name
- Betulonic Acid
- Packaging
- 10mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 29765
- Product name
- Betulonic Acid
- Packaging
- 25mg
- Price
- $116
- Updated
- 2024/03/01
Betulonicacid Chemical Properties,Usage,Production
Chemical Properties
Betulin ketoacetic acid in the form of a white crystalline powder is a pentacyclic triterpenoid widely distributed in a variety of plants, and its content in the bark of Betula alba ranges from 0.25 to 2% (in dry form).
Uses
(+)-Betulonic Acid shows potent cytotoxic activities against PC3, MGC-803, Bcap-37, and MCF-7 cell lines.
Definition
ChEBI: Betulonic acid is a triterpenoid. It has a role as an anticoronaviral agent.
Synthesis
472-15-1
4481-62-3
General procedure for the synthesis of 3-oxo-lupin-20(29)-en-28-oic acid from betulinic acid: 1. preparation of Jones' reagent: chromium trioxide (CrO3, 26.72 g) was dissolved in concentrated sulfuric acid (H2SO4, 23 ml) and the solution was subsequently diluted to 100 ml with water. 2. Reaction process: Betulinic acid (BA, 500 mg, 1.09 mmol) was dissolved in a solvent mixture of dichloromethane (CH2Cl2, 12 ml) and acetone (12 ml), and Jones reagent (1 ml) was added slowly after cooling. 3. Reaction control: the reaction mixture was stirred at room temperature for 15 min followed by addition of methanol (MeOH, 5 ml) to terminate the reaction. After continued stirring for 10 minutes, the reaction mixture was diluted by adding dichloromethane (CH2Cl2, 20 ml). 4. Post-treatment: The organic layer was washed sequentially with water and saturated sodium chloride (NaCl) solution, dried with anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under vacuum. 5. Purification: the crude product was recrystallized three times in methanol (MeOH) to give 3-oxo lupin-20(29)-en-28-oic acid (462 mg, 93% yield) as a white solid.
IC 50
Plasmodium; HSV-1
References
[1] Phytochemistry, 1998, vol. 49, # 3, p. 709 - 717
[2] Journal of Asian Natural Products Research, 2014, vol. 16, # 1, p. 34 - 42
[3] Chinese Chemical Letters, 2015, vol. 26, # 6, p. 759 - 762
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 7, p. 3122 - 3134
[5] European Journal of Medicinal Chemistry, 2015, vol. 95, p. 240 - 248
Betulonicacid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Betulonicacid manufacturers
- Product
- Betulonicacid 4481-62-3
- Price
- US $10.00/KG
- Min. Order
- 100KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-12-05
- Product
- Liquidambaric acid 4481-62-3
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-10-11
- Product
- Liquidambaric acid 4481-62-3
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- Analytical Standard
- Supply Ability
- 10 g
- Release date
- 2019-10-11