ChemicalBook > CAS DataBase List > Betulonicacid

Betulonicacid

Product Name: Betulonicacid
CAS No.: 4481-62-3
Chemical Name: Betulonicacid
Synonyms: Prazocin;Prazosine;LiquidaMba;Betulonicaci;Betunolic acid;Betulonic acid;Lulu Tong acid;Betulinonic acid;Betulonic Acid(P);Betulonic acid-RM
CBNumber: CB91075473
Molecular Formula: C30H46O3
Formula Weight: 454.68
MOL File: 4481-62-3.mol

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Betulonicacid Property

Melting point:: 253 °C
Boiling point:: 548.1±33.0 °C(Predicted)
Density: 1.061±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Solid
pka: 4.62±0.70(Predicted)
color: White to Off-White
InChIKey: SLJTWDNVZKIDAU-SVAFSPIFSA-N
SMILES: C1(=O)[C@@]([C@]2([C@](C)(CC1)[C@]1([H])[C@@]([C@]3([C@@](CC1)([H])[C@@]1([C@@](CC[C@H]1C(C)=C)(C(O)=O)CC3)[H])C)(C)CC2)[H])(C)C

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Safety

Safety Statements: 24/25
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H227Combustible liquid

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P234Keep only in original container.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P370+P378In case of fire: Use … for extinction.

P390Absorb spillage to prevent material damage.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL83839
Product name: Betulonic acid
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $363
Updated: 2025/07/31

TCI Chemical

Product number: B6085
Product name: Betulonic Acid
Packaging: 50MG
Price: $177
Updated: 2025/07/31

TCI Chemical

Product number: B6085
Product name: Betulonic Acid
Packaging: 250MG
Price: $619
Updated: 2025/07/31

Cayman Chemical

Product number: 29765
Product name: Betulonic Acid
Packaging: 10mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 29765
Product name: Betulonic Acid
Packaging: 25mg
Price: $116
Updated: 2024/03/01

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Betulonicacid Chemical Properties,Usage,Production

Chemical Properties

Betulin ketoacetic acid in the form of a white crystalline powder is a pentacyclic triterpenoid widely distributed in a variety of plants, and its content in the bark of Betula alba ranges from 0.25 to 2% (in dry form).

Uses

(+)-Betulonic Acid shows potent cytotoxic activities against PC3, MGC-803, Bcap-37, and MCF-7 cell lines.

Definition

ChEBI: Betulonic acid is a triterpenoid. It has a role as an anticoronaviral agent.

Synthesis

472-15-1

4481-62-3

General procedure for the synthesis of 3-oxo-lupin-20(29)-en-28-oic acid from betulinic acid: 1. preparation of Jones' reagent: chromium trioxide (CrO3, 26.72 g) was dissolved in concentrated sulfuric acid (H2SO4, 23 ml) and the solution was subsequently diluted to 100 ml with water. 2. Reaction process: Betulinic acid (BA, 500 mg, 1.09 mmol) was dissolved in a solvent mixture of dichloromethane (CH2Cl2, 12 ml) and acetone (12 ml), and Jones reagent (1 ml) was added slowly after cooling. 3. Reaction control: the reaction mixture was stirred at room temperature for 15 min followed by addition of methanol (MeOH, 5 ml) to terminate the reaction. After continued stirring for 10 minutes, the reaction mixture was diluted by adding dichloromethane (CH2Cl2, 20 ml). 4. Post-treatment: The organic layer was washed sequentially with water and saturated sodium chloride (NaCl) solution, dried with anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under vacuum. 5. Purification: the crude product was recrystallized three times in methanol (MeOH) to give 3-oxo lupin-20(29)-en-28-oic acid (462 mg, 93% yield) as a white solid.

IC 50

Plasmodium; HSV-1

References

[1] Phytochemistry, 1998, vol. 49, # 3, p. 709 - 717
[2] Journal of Asian Natural Products Research, 2014, vol. 16, # 1, p. 34 - 42
[3] Chinese Chemical Letters, 2015, vol. 26, # 6, p. 759 - 762
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 7, p. 3122 - 3134
[5] European Journal of Medicinal Chemistry, 2015, vol. 95, p. 240 - 248

Betulonicacid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Betulonicacid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Betulonicacid 4481-62-3
Price: US $10.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-12-05

Shanghai Standard Technology Co., Ltd.

Product: Liquidambaric acid 4481-62-3
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-10-11

Shanghai Standard Technology Co., Ltd.

Product: Liquidambaric acid 4481-62-3
Price: US $0.00/mg
Min. Order: 5mg
Purity: Analytical Standard
Supply Ability: 10 g
Release date: 2019-10-11

4481-62-3, BetulonicacidRelated Search:

Terrestrosin K roburic acid Pachymic acid LiquidaMbaric lactone Poricoic acid A(F) Terrestrosin D Carboxyatractyloside ALLEOSIDE A Nalidixic acid 4,4'-Carbonyldiphthalic acid Betulinic acid Betulinicaldehyde Betulin LUPENONE Betulonicacid Betulonicacidmethylester LUP-20(29)-ENE 6-HEPTYLDECAHYDRONAPHTHALENE-2-CARBOXYLIC ACID

Betulinonic acid

LiquidaMba

Betulonic acid

Liquidambaric acid

(+)-Betulonic acid, 98%, from Liquidambar formosana Hance

Liquidambaric acid 4481-62-3

Betunolic acid

Lup-20(29)-en-28-oic acid, 3-oxo-

Betulonicaci

Lup-20(29)-ene-28-oic acid,3-oxo

Betulonicacid 4481-62-3

Prazocin

Prazosine

Lulu Tong acid

Betulonic Acid(P)

Betulonic acid-RM

Betulonic acid, 10 mM in DMSO

4481-62-3

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract