4-AMINO-3,5-DIBROMOPYRIDINE

Product Name: 4-AMINO-3,5-DIBROMOPYRIDINE
CAS No.: 84539-34-4
Chemical Name: 4-AMINO-3,5-DIBROMOPYRIDINE
Synonyms: 3,5-DIBROMOPYRIDIN-4-AMINE;AURORA 15013;IFLAB-BB F1371-0141;OTAVA-BB BB7110951384;3,5-Dibromo-4-pyridinamine;4-aMino-3,5-dibroMopyridin;3,5-dibroMo-4-aMinopyridin;4-AMINO-3,5-DIBROMOPYRIDINE;3,5-dibromo-4-aminopyridine;4-Pyridinamine, 3,5-dibromo-
CBNumber: CB9108891
Molecular Formula: C5H4Br2N2
Formula Weight: 251.91
MOL File: 84539-34-4.mol

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4-AMINO-3,5-DIBROMOPYRIDINE Property

Melting point:: 165-170 °C
Boiling point:: 292.9±35.0 °C(Predicted)
Density: 2.147
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: 4.96±0.24(Predicted)
color: Light yellow to Yellow to Orange

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Safety

Hazard Codes: Xi,T
Risk Statements: 25-37/38-41
Safety Statements: 26-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1162556
Product name: Dalfampridine Related Compound B
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 50mg
Price: $1150
Updated: 2025/07/31

Sigma-Aldrich

Product number: 758426
Product name: 4-Amino-3,5-dibromopyridine
Purity: 95%
Packaging: 1g
Price: $83.5
Updated: 2023/06/20

TCI Chemical

Product number: A2309
Product name: 4-Amino-3,5-dibromopyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $140
Updated: 2025/07/31

TRC

Product number: A610688
Product name: 4-Amino-3,5-dibromopyridine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 074743
Product name: 4-Amino-3,5-dibromopyridine
Purity: 95+%
Packaging: 1g
Price: $59
Updated: 2021/12/16

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4-AMINO-3,5-DIBROMOPYRIDINE Chemical Properties,Usage,Production

Chemical Properties

white solid

Uses

4-Amino-3,5-dibromopyridine is an important synthetic intermediate of a natural product Desmopyradine, can be converted into another important pyridine intermediate such as 3, 5-dibromopyridine, 3, 5-dibromo-4-iodopyridine and the like, and has important synthetic value.

Preparation

A preparation method of 4-Amino-3,5-dibromopyridine is characterized by comprising the following steps: pyridine or pyridine salt is taken as raw material, ammonium salt and H are added into HBr solution2O2And reacting in one step to obtain the 4-Amino-3,5-dibromopyridine.

Synthesis

504-24-5

84539-34-4

General procedure for the synthesis of 4-amino-3,5-dibromopyridine from 4-aminopyridine: To a suspension of 4-aminopyridine (188.2 mg, 2.0 mmol, 1.0 eq.) in dichloromethane (10 mL) was added slowly over a period of 1 hour a dichloromethane (30 mL) solution of N-bromosuccinimide (818.7 mg, 4.6 mmol, 2.3 eq.). ) solution. The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give a mixture of succinimide and 4-amino-3,5-dibromopyridine. The mixture was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 1/1) to afford the target product 4-amino-3,5-dibromopyridine (464.8 mg, 1.84 mmol, 92% yield) as a colorless solid. Thin layer chromatography (TLC) Rf value was 0.62 (unfolding agent: hexane/ethyl acetate = 1/1). The melting point is 163-167 °C. Infrared spectrum (KBr, cm^-1): 3535, 3429, 3266, 3100, 2667, 2536, 2329, 1872, 1825, 1785, 1626, 1566, 1522, 1485, 1408, 1323, 1262, 1154, 1138, 1081, 1051, 892, 855. 747, 726, 658, 589, 573, 517, 468, 431.NMR hydrogen spectrum (300 MHz, CDCl3) δ 8.31 (2H, s, H2/6), 5.06 (2H, s, NH). NMR carbon spectra (75 MHz, CDCl3) δ 149.9, 147.8, 106.2. electron bombardment mass spectra (EI-MS) m/z calculated value C5H4Br2N2 [M]+ 249.87, measured value 249.90.

References

[1] Synthesis, 2001, # 14, p. 2175 - 2179
[2] Chemistry - A European Journal, 2012, vol. 18, # 20, p. 6328 - 6334
[3] Tetrahedron Asymmetry, 2012, vol. 23, # 22-23, p. 1557 - 1563
[4] Patent: CN106957259, 2017, A. Location in patent: Paragraph 0015; 0017; 0019
[5] Angewandte Chemie - International Edition, 2017, vol. 56, # 16, p. 4575 - 4578

4-AMINO-3,5-DIBROMOPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-AMINO-3,5-DIBROMOPYRIDINE Suppliers

Americas 1 Austria 1 Canada 1 China 156 Europe 1 France 1 Germany 2 India 8 Japan 1 The Netherlands 1 Ukraine 1 United Kingdom 4 United States 18 Global 196

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View Lastest Price from 4-AMINO-3,5-DIBROMOPYRIDINE manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: 4-AMINO-3,5-DIBROMOPYRIDINE 84539-34-4
Price: US $85.00-850.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-08

Henan Fengda Chemical Co., Ltd

Product: 3,5-Dibromo-4-pyridinamine 84539-34-4
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-02

Dideu Industries Group Limited

Product: 4-AMINO-3,5-DIBROMOPYRIDINE 84539-34-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-20

84539-34-4, 4-AMINO-3,5-DIBROMOPYRIDINERelated Search:

3-Amino-2,6-dibromopyridine ,98%,3-AMINO-2,6-DIBROMOPYRIDINE(2-AMINO-5-NITRO-4-METHYLPYRIDINE),3-AMINO-2,6-DIBROMOPYRIDINE 3,5-Dibromopyridine 4-AMINO-2,6-DIBROMOPYRIDINE 3-AMINO-4,6-DIBROMOPYRIDINE 2-AMINO-3,5-DIBROMOPYRIDINE,2-Amino-3,5-dibromopyridine&nbsp 3-Amino-5,6-dibromopyridine 3,5-DIBROMO-4-NITROPYRIDINE 4-AMINO-3,5-DIBROMO-2-METHYLPYRIDINE 4-AMINO-2,3,5-TRIBROMOPYRIDINE 3,5-DIBROMO-4-NITROPYRIDINE-N-OXIDE 4-AMINO-3,5-DIBROMOPYRIDINE 6-Amino-2,3-dibromopyridine 3-Amino-2,5-dibromopyridine 5-Amino-2,3-dibromopyridine 3-Amino-2,4-dibromopyridine 6-AMINO-3,5-DIBROMOPYRIDINE-2-CARBOXAMIDE 6-AMINO-3,5-DIBROMOPYRIDINE-2-CARBONITRILE TERT-BUTYL 3,5-DIBROMOPYRIDIN-4-YLCARBAMATE

OTAVA-BB BB7110951384

AURORA 15013

IFLAB-BB F1371-0141

4-AMINO-3,5-DIBROMOPYRIDINE

3,5-DIBROMOPYRIDIN-4-AMINE

3,5-dibromo-4-aminopyridine

3,5-dibroMo-4-aMinopyridin

4-aMino-3,5-dibroMopyridin

4-Amino-3,5-dibromopyridine 3,5-Dibromopyridin-4-amine

3,5-Dibromo-4-pyridinamine

3,5-Dibromo-pyridin-4-ylamine

Dalfampridine Related Compound B

4-Pyridinamine, 3,5-dibromo-

4-AMINO-3,5-DIBROMOPYRIDINE ISO 9001：2015 REACH

Dalfampridine Related Compound B (1162556)

84539-34-4

Heterocycle-Pyridine series