ChemicalBook > CAS DataBase List > 4-AMINO-3,5-DIBROMOPYRIDINE

4-AMINO-3,5-DIBROMOPYRIDINE

Product Name
4-AMINO-3,5-DIBROMOPYRIDINE
CAS No.
84539-34-4
Chemical Name
4-AMINO-3,5-DIBROMOPYRIDINE
Synonyms
3,5-DIBROMOPYRIDIN-4-AMINE;AURORA 15013;IFLAB-BB F1371-0141;OTAVA-BB BB7110951384;3,5-Dibromo-4-pyridinamine;4-aMino-3,5-dibroMopyridin;3,5-dibroMo-4-aMinopyridin;4-AMINO-3,5-DIBROMOPYRIDINE;3,5-dibromo-4-aminopyridine;4-Pyridinamine, 3,5-dibromo-
CBNumber
CB9108891
Molecular Formula
C5H4Br2N2
Formula Weight
251.91
MOL File
84539-34-4.mol
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4-AMINO-3,5-DIBROMOPYRIDINE Property

Melting point:
165-170 °C
Boiling point:
292.9±35.0 °C(Predicted)
Density 
2.147
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
4.96±0.24(Predicted)
color 
Light yellow to Yellow to Orange
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Safety

Hazard Codes 
Xi,T
Risk Statements 
25-37/38-41
Safety Statements 
26-45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1162556
Product name
Dalfampridine Related Compound B
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50mg
Price
$1150
Updated
2025/07/31
Sigma-Aldrich
Product number
758426
Product name
4-Amino-3,5-dibromopyridine
Purity
95%
Packaging
1g
Price
$83.5
Updated
2023/06/20
TCI Chemical
Product number
A2309
Product name
4-Amino-3,5-dibromopyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$140
Updated
2025/07/31
TRC
Product number
A610688
Product name
4-Amino-3,5-dibromopyridine
Packaging
10mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
074743
Product name
4-Amino-3,5-dibromopyridine
Purity
95+%
Packaging
1g
Price
$59
Updated
2021/12/16
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4-AMINO-3,5-DIBROMOPYRIDINE Chemical Properties,Usage,Production

Chemical Properties

white solid

Uses

4-Amino-3,5-dibromopyridine is an important synthetic intermediate of a natural product Desmopyradine, can be converted into another important pyridine intermediate such as 3, 5-dibromopyridine, 3, 5-dibromo-4-iodopyridine and the like, and has important synthetic value.

Preparation

A preparation method of 4-Amino-3,5-dibromopyridine is characterized by comprising the following steps: pyridine or pyridine salt is taken as raw material, ammonium salt and H are added into HBr solution2O2And reacting in one step to obtain the 4-Amino-3,5-dibromopyridine.

Synthesis

504-24-5

84539-34-4

General procedure for the synthesis of 4-amino-3,5-dibromopyridine from 4-aminopyridine: To a suspension of 4-aminopyridine (188.2 mg, 2.0 mmol, 1.0 eq.) in dichloromethane (10 mL) was added slowly over a period of 1 hour a dichloromethane (30 mL) solution of N-bromosuccinimide (818.7 mg, 4.6 mmol, 2.3 eq.). ) solution. The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give a mixture of succinimide and 4-amino-3,5-dibromopyridine. The mixture was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 1/1) to afford the target product 4-amino-3,5-dibromopyridine (464.8 mg, 1.84 mmol, 92% yield) as a colorless solid. Thin layer chromatography (TLC) Rf value was 0.62 (unfolding agent: hexane/ethyl acetate = 1/1). The melting point is 163-167 °C. Infrared spectrum (KBr, cm^-1): 3535, 3429, 3266, 3100, 2667, 2536, 2329, 1872, 1825, 1785, 1626, 1566, 1522, 1485, 1408, 1323, 1262, 1154, 1138, 1081, 1051, 892, 855. 747, 726, 658, 589, 573, 517, 468, 431.NMR hydrogen spectrum (300 MHz, CDCl3) δ 8.31 (2H, s, H2/6), 5.06 (2H, s, NH). NMR carbon spectra (75 MHz, CDCl3) δ 149.9, 147.8, 106.2. electron bombardment mass spectra (EI-MS) m/z calculated value C5H4Br2N2 [M]+ 249.87, measured value 249.90.

References

[1] Synthesis, 2001, # 14, p. 2175 - 2179
[2] Chemistry - A European Journal, 2012, vol. 18, # 20, p. 6328 - 6334
[3] Tetrahedron Asymmetry, 2012, vol. 23, # 22-23, p. 1557 - 1563
[4] Patent: CN106957259, 2017, A. Location in patent: Paragraph 0015; 0017; 0019
[5] Angewandte Chemie - International Edition, 2017, vol. 56, # 16, p. 4575 - 4578

4-AMINO-3,5-DIBROMOPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-AMINO-3,5-DIBROMOPYRIDINE Suppliers

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View Lastest Price from 4-AMINO-3,5-DIBROMOPYRIDINE manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd
Product
4-AMINO-3,5-DIBROMOPYRIDINE 84539-34-4
Price
US $85.00-850.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-08
Henan Fengda Chemical Co., Ltd
Product
3,5-Dibromo-4-pyridinamine 84539-34-4
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-02
Dideu Industries Group Limited
Product
4-AMINO-3,5-DIBROMOPYRIDINE 84539-34-4
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-08-20

84539-34-4, 4-AMINO-3,5-DIBROMOPYRIDINERelated Search:

3-Amino-2,6-dibromopyridine ,98%,3-AMINO-2,6-DIBROMOPYRIDINE(2-AMINO-5-NITRO-4-METHYLPYRIDINE),3-AMINO-2,6-DIBROMOPYRIDINE 3,5-Dibromopyridine 4-AMINO-2,6-DIBROMOPYRIDINE 3-AMINO-4,6-DIBROMOPYRIDINE 2-AMINO-3,5-DIBROMOPYRIDINE,2-Amino-3,5-dibromopyridine&nbsp 3-Amino-5,6-dibromopyridine 3,5-DIBROMO-4-NITROPYRIDINE 4-AMINO-3,5-DIBROMO-2-METHYLPYRIDINE 4-AMINO-2,3,5-TRIBROMOPYRIDINE 3,5-DIBROMO-4-NITROPYRIDINE-N-OXIDE 4-AMINO-3,5-DIBROMOPYRIDINE 6-Amino-2,3-dibromopyridine 3-Amino-2,5-dibromopyridine 5-Amino-2,3-dibromopyridine 3-Amino-2,4-dibromopyridine 6-AMINO-3,5-DIBROMOPYRIDINE-2-CARBOXAMIDE 6-AMINO-3,5-DIBROMOPYRIDINE-2-CARBONITRILE TERT-BUTYL 3,5-DIBROMOPYRIDIN-4-YLCARBAMATE

  • OTAVA-BB BB7110951384
  • AURORA 15013
  • IFLAB-BB F1371-0141
  • 4-AMINO-3,5-DIBROMOPYRIDINE
  • 3,5-DIBROMOPYRIDIN-4-AMINE
  • 3,5-dibromo-4-aminopyridine
  • 3,5-dibroMo-4-aMinopyridin
  • 4-aMino-3,5-dibroMopyridin
  • 4-Amino-3,5-dibromopyridine 3,5-Dibromopyridin-4-amine
  • 3,5-Dibromo-4-pyridinamine
  • 3,5-Dibromo-pyridin-4-ylamine
  • Dalfampridine Related Compound B
  • 4-Pyridinamine, 3,5-dibromo-
  • 4-AMINO-3,5-DIBROMOPYRIDINE ISO 9001：2015 REACH
  • Dalfampridine Related Compound B (1162556)
  • 84539-34-4
  • Heterocycle-Pyridine series