3-Bromo-2-fluoroaniline
- Product Name
- 3-Bromo-2-fluoroaniline
- CAS No.
- 58534-95-5
- Chemical Name
- 3-Bromo-2-fluoroaniline
- Synonyms
- 3-Bromo-2-fluorobenzenamine;3-Bromo-2-fluoroaniline;3-Brome-2-fluoroaniline;3-Bromo-2-fluorophenylamine;3-Bromo-2-fluoroaniline 99%;BenzenaMine, 3-broMo-2-fluoro-;3-bromo-2-fluoroaniline hydrochloride;3-Bromo-2-fluoroaniline ISO 9001：2015 REACH
- CBNumber
- CB91107268
- Molecular Formula
- C6H5BrFN
- Formula Weight
- 190.01
- MOL File
- Mol file
3-Bromo-2-fluoroaniline Property
- Boiling point:
- 228℃
- Density
- 1.694
- Flash point:
- 91℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.13±0.10(Predicted)
- form
- liquid
- color
- Clear, light yellow
- InChI
- InChI=1S/C6H5BrFN/c7-4-2-1-3-5(9)6(4)8/h1-3H,9H2
- InChIKey
- HYPQOSVTIONWSN-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=CC(Br)=C1F
Safety
- Safety Statements
- 24/25
- RIDADR
- UN2941
- HazardClass
- 6.1
- HS Code
- 29214300
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- CDS023142
- Product name
- 3-Bromo-2-fluoroaniline
- Packaging
- 10 mg
- Price
- $36.7
- Updated
- 2025/07/31
- Product number
- B700283
- Product name
- 3-Bromo-2-fluoroaniline
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- B700283
- Product name
- 3-Bromo-2-fluoroaniline
- Packaging
- 5g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- PC8089
- Product name
- 3-Bromo-2-fluoroaniline
- Purity
- 98%
- Packaging
- 25g
- Price
- $153
- Updated
- 2021/12/16
- Product number
- 077980
- Product name
- 3-Bromo-2-fluoroaniline
- Purity
- 99%
- Packaging
- 25g
- Price
- $195
- Updated
- 2021/12/16
3-Bromo-2-fluoroaniline Chemical Properties,Usage,Production
Description
3-Bromo-2-fluoroaniline is an aniline derivative with reactive groups (fluorine and bromine atoms). It is widely used in organic synthesis and can be used as a starting material for the synthesis of KRASG12C inhibitors, which have antitumour activity and can be used in the development of anticancer drugs.
Uses
3-Bromo-2-fluoroaniline is used in the preparation of heterotricyclic carboxamides as RIG-1 agonists for treatment cell proliferation disorders.
Synthesis
58534-94-4
58534-95-5
General procedure for the synthesis of 3-bromo-2-fluoroaniline from 2-fluoro-3-bromonitrobenzene: To a mixed solution of 1-bromo-2-fluoro-3-nitrobenzene (13.75 g, 62.76 mmol), acetic acid (26.36 g, 439 mmol), ethanol (150 mL), and water (60 mL) was added, in portions, at room temperature, powdered iron (9.14 g, 163 mmol). The reaction mixture was stirred for 16 h at room temperature and subsequently neutralized with 5N sodium hydroxide solution. The neutralized mixture was extracted with ethyl acetate and the organic layer was sequentially washed with saturated brine, dried over anhydrous sodium sulfate and finally concentrated under reduced pressure. The residue was purified by silica gel fast column chromatography (petroleum ether/ethyl acetate=10:1) to afford the target product 3-bromo-2-fluoroaniline (7.77 g, 65% yield) as a brown oil.
References
[1] Patent: US2011/34450, 2011, A1. Location in patent: Page/Page column 95
[2] Patent: WO2017/15562, 2017, A1. Location in patent: Page/Page column 93-94
[3] Patent: WO2017/87528, 2017, A1. Location in patent: Page/Page column 180; 181
[4] Patent: WO2017/58915, 2017, A1. Location in patent: Page/Page column 102
[5] Patent: US2018/15087, 2018, A1. Location in patent: Paragraph 0318
3-Bromo-2-fluoroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Bromo-2-fluoroaniline manufacturers
- Product
- 3-Bromo-2-fluoroaniline 58534-95-5
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-08-06
- Product
- 3-Bromo-2-fluoroaniline 58534-95-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-04-29
- Product
- 3-Bromo-2-fluoroaniline 58534-95-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-01