2-Bromo-5-fluorobenzyl alcohol
- Product Name
- 2-Bromo-5-fluorobenzyl alcohol
- CAS No.
- 202865-66-5
- Chemical Name
- 2-Bromo-5-fluorobenzyl alcohol
- Synonyms
- CAS:202865-66-5;BUTTPARK 87\01-69;RARECHEM AL BD 0749;Tavaborole Intermediate;Tavaborole Alcohol impurity;2-Ethoxy-4-fluorobromobenzene;2-BROMO-5-FLUOROBENZYL ALCOHOL;2-Bromo-5-fluorobenzenemethanol;(2-Bromo-5-fluorophenyl)methanol;Benzenemethanol,2-bromo-5-fluoro-
- CBNumber
- CB9670255
- Molecular Formula
- C7H6BrFO
- Formula Weight
- 205.02
- MOL File
- 202865-66-5.mol
2-Bromo-5-fluorobenzyl alcohol Property
- Melting point:
- 91-94 °C
- Boiling point:
- 252.5±25.0 °C(Predicted)
- Density
- 1.658±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 13.67±0.10(Predicted)
- form
- Solid
- color
- Yellow
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C7H6BrFO/c8-7-2-1-6(9)3-5(7)4-10/h1-3,10H,4H2
- InChIKey
- HXGZPMHPSBJMKB-UHFFFAOYSA-N
- SMILES
- C1(CO)=CC(F)=CC=C1Br
- CAS DataBase Reference
- 202865-66-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-36-22
- Safety Statements
- 26-36
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 2906290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 665827
- Product name
- 2-Bromo-5-fluorobenzyl alcohol
- Purity
- 97%
- Packaging
- 5g
- Price
- $184
- Updated
- 2023/06/20
- Product number
- B692103
- Product name
- 2-Bromo-5-fluorobenzyl alcohol
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- B692103
- Product name
- 2-Bromo-5-fluorobenzyl alcohol
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 074527
- Product name
- (2-Bromo-5-fluorophenyl)methanol
- Purity
- 95+%
- Packaging
- 5g
- Price
- $82
- Updated
- 2021/12/16
- Product number
- J54027
- Product name
- 2-Bromo-5-fluorobenzyl alcohol
- Packaging
- 25g
- Price
- $40
- Updated
- 2021/12/16
2-Bromo-5-fluorobenzyl alcohol Chemical Properties,Usage,Production
Chemical Properties
Colorless liquid
Uses
2-Bromo-5-fluorobenzyl alcohol is used as intermediates in pharmaceutical and organic synthesis.
Synthesis
94569-84-3
202865-66-5
General procedure for the synthesis of 2-bromo-5-fluorobenzyl alcohol from 2-bromo-5-fluorobenzaldehyde: To a solution of 2-bromo-5-fluorobenzaldehyde (75.0 g, 369 mmol) in ethanol (375 mL) was slowly added a solution of sodium borohydride (4.47 g, 118 mmol) in water (9 mL) at 0 °C. The reaction mixture was kept stirred at 0°C for 1 hour. Upon completion of the reaction, the mixture was treated with water and ethyl acetate and extracted with ethyl acetate. The combined organic extracts were washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give 75.6 g of 2-bromo-5-fluorobenzyl alcohol (yield = 99.8%) as a colorless solid.1H NMR (CDCl3) δ 7.50-7.46 (1H, m), 7.29-7.25 (1H, m), 6.92-6.85 (1H, m), 4.72 (2H, s).
References
[1] Journal of Organic Chemistry, 2005, vol. 70, # 2, p. 756 - 759
[2] Patent: WO2007/19098, 2007, A2. Location in patent: Page/Page column 44
[3] Tetrahedron, 2007, vol. 63, # 38, p. 9401 - 9405
[4] Patent: CN108358961, 2018, A. Location in patent: Paragraph 0016; 0057; 0058-0060; 0062; 0069; 0071; 0078
[5] CrystEngComm, 2014, vol. 16, # 23, p. 4999 - 5011
2-Bromo-5-fluorobenzyl alcohol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-5-fluorobenzyl alcohol manufacturers
- Product
- 2-Bromo-5-fluorobenzyl alcohol 202865-66-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
- Product
- 2-Bromo-5-fluorobenzyl alcohol 202865-66-5
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-16
- Product
- 2-Bromo-5-fluorobenzyl alcohol 202865-66-5
- Price
- US $0.00/KG Ton
- Min. Order
- 1KG Ton
- Purity
- 98%+
- Supply Ability
- 2 tons/month
- Release date
- 2022-10-10