Bindarit

Product Name: Bindarit
CAS No.: 130641-38-2
Chemical Name: Bindarit
Synonyms: AF 2838;CS-1989;Bindarit;Bindarit (AF2838);AF2838;AF-2838;AF 2838;2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid;2-((1-Benzyl-1H-indazol-3-yl)Methoxy)-2-Methylpropanoic acid;2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropionic acid;Propanoic acid, 2-Methyl-2-[[1-(phenylMethyl)-1H-indazol-3-yl]Methoxy]-
CBNumber: CB91118288
Molecular Formula: C19H20N2O3
Formula Weight: 324.37
MOL File: 130641-38-2.mol

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Bindarit Property

Boiling point:: 542.9±40.0 °C(Predicted)
Density: 1.18±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: 2-8°C
solubility: DMSO:47.0(Max Conc. mg/mL);144.89(Max Conc. mM)
form: A crystalline solid
pka: 3.59±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11479
Product name: Bindarit
Purity: ≥98%
Packaging: 1mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 11479
Product name: Bindarit
Purity: ≥98%
Packaging: 5mg
Price: $88
Updated: 2024/03/01

Cayman Chemical

Product number: 11479
Product name: Bindarit
Purity: ≥98%
Packaging: 10mg
Price: $150
Updated: 2024/03/01

Cayman Chemical

Product number: 11479
Product name: Bindarit
Purity: ≥98%
Packaging: 25mg
Price: $250
Updated: 2024/03/01

Usbiological

Product number: 003975
Product name: Bindarit
Packaging: 5mg
Price: $460
Updated: 2021/12/16

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Bindarit Chemical Properties,Usage,Production

Description

Bindarit is an inhibitor of monocyte chemoattractant protein (MCP) production that is selective for MCP-1/CCL2, MPC-3/CCL7, and MCP-2/CCL8 over other chemokines. It inhibits LPS- or C. albicans-induced production of MCP-1/CCL2 in isolated human monocytes (IC₅₀s = 172 and 403 μM, respectively). Bindarit downregulates NF-κB signaling and prevents p65 and p65/p50-mediated MCP-1/CCL2 promoter activation in RAW264.7 cells. It delays the onset of proteinuria and prolongs survival in a mouse model of experimental lupus nephritis when administered at a dose of 50 mg/kg. It prevents LPS-induced increases in MCP-1/CCL2 expression in mouse brain and spinal cord when administered at a dose of 200 mg/kg and reduces the incidence and severity of experimental autoimmune encephalomyelitis (EAE) in mice. Bindarit is also a noncompetitive inhibitor of monocarboxylate transporter 4 (MCT4; K_i = 30.2 μM for the human transporter) that is selective for MCT4 over MCT1.

Uses

Bindarit shows anti-inflammatory activity due to a selective inhibition of a subfamily of inflammatory chemokines. Bindarit is a also protein antidenaturant agent. Bindarit modulates the NFkB pathway and has been shown to reduce secondary phase of adjuvant arthritis in rats.

Uses

Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.

Bindarit Preparation Products And Raw materials

Raw materials

Preparation Products

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Bindarit Suppliers

Canada 1 China 128 India 2 United Kingdom 2 United States 15 Global 148

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63711
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
Advantage: 58

130641-38-2, BindaritRelated Search:

Imatinib Fasudil hydrochloride Dasatinib Avasimibe Entinostat Olaparib (1-METHYL-1H-INDAZOL-3-YL)METHANOL Bindarit 3-(HYDROXYMETHYL)INDAZOLE 3-METHYL-1H-INDAZOLE 1-BENZYL-3-HYDROXYMETHYL-1H-INDAZOLE 1-BENZYL-3-METHYL-1H-INDAZOLE

Bindarit

Propanoic acid, 2-Methyl-2-[[1-(phenylMethyl)-1H-indazol-3-yl]Methoxy]-

2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropionic acid

AF 2838

2-((1-Benzyl-1H-indazol-3-yl)Methoxy)-2-Methylpropanoic acid

AF2838;AF-2838;AF 2838

CS-1989

2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid

Bindarit (AF2838)

130641-38-2

Aromatics

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals