Catalyst of Organic synthesis Electrolytic preparation of tetramethylammonium hydroxide The preparation of PHBHQ type thermoset Liquid crystalline epoxy resin (LCER) Uses
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Tetramethylammonium chloride

Catalyst of Organic synthesis Electrolytic preparation of tetramethylammonium hydroxide The preparation of PHBHQ type thermoset Liquid crystalline epoxy resin (LCER) Uses
Product Name
Tetramethylammonium chloride
CAS No.
75-57-0
Chemical Name
Tetramethylammonium chloride
Synonyms
TMA;TMAC;TMACL;50g;Tetramethylammoniumchlorid;N,N,N-trimethylmethanaminium chloride;usafan-8;USAF AN-8;N1,1,1,1Cl;tetraminechloride
CBNumber
CB9118809
Molecular Formula
C4H12ClN
Formula Weight
109.6
MOL File
75-57-0.mol
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Tetramethylammonium chloride Property

Melting point:
>300 °C (lit.)
Boiling point:
165.26°C (rough estimate)
Density 
1,17 g/cm3
refractive index 
1.5320 (estimate)
storage temp. 
Store below +30°C.
solubility 
methanol: 0.1 g/mL, clear, colorless
form 
Hygroscopic Crystalline Powder
Specific Gravity
1.169
color 
White to ivory
PH
6-8 (100g/l, H2O, 20℃)
Odor
Odorless
PH Range
6 - 8
Water Solubility 
>60 g/100 mL (20 ºC)
Sensitive 
Hygroscopic
λmax
λ: 260 nm Amax: 0.02
λ: 280 nm Amax: 0.02
BRN 
2496575
Stability:
Stable. Incompatible with strong oxidizing agents, water. Hygroscopic.
CAS DataBase Reference
75-57-0(CAS DataBase Reference)
NIST Chemistry Reference
Tetramethylammonium chloride(75-57-0)
EPA Substance Registry System
Tetramethylammonium chloride (75-57-0)
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Safety

Hazard Codes 
T,Xn
Risk Statements 
21-25-36/37/38-20/21/22
Safety Statements 
26-36/37-45-37/39-28A-28-36
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
1
RTECS 
BS7700000
F 
3-10
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29239000
Hazardous Substances Data
75-57-0(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 50 mg/kg LD50 dermal Rat 537 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H311Toxic in contact with skin

H315Causes skin irritation

H370Causes damage to organs

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.22156
Product name
Tetramethylammonium chloride
Purity
for synthesis
Packaging
250g
Price
$69.1
Updated
2024/03/01
Sigma-Aldrich
Product number
8.22156
Product name
Tetramethylammonium chloride
Purity
for synthesis
Packaging
1kg
Price
$169
Updated
2024/03/01
Sigma-Aldrich
Product number
8.22156
Product name
Tetramethylammonium chloride
Purity
for synthesis
Packaging
5kg
Price
$368
Updated
2024/03/01
Sigma-Aldrich
Product number
74202
Product name
Tetramethylammonium chloride
Purity
suitable for ion pair chromatography, LiChropur?, ≥99.0% (AT)
Packaging
50g
Price
$81.9
Updated
2024/03/01
Sigma-Aldrich
Product number
74202
Product name
Tetramethylammonium chloride
Purity
suitable for ion pair chromatography, LiChropur?, ≥99.0% (AT)
Packaging
250g
Price
$327
Updated
2024/03/01
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Tetramethylammonium chloride Chemical Properties,Usage,Production

Catalyst of Organic synthesis

Tetramethylammonium chloride is the phase transfer catalyst in organic synthesis phase with its catalytic activity being stronger than triphenylphosphine and triethylamine. At room temperature, it is a white crystalline powder, and is volatile, irritant, and easy to absorb moisture. It is easily soluble in methanol, soluble in water and hot ethanol but insoluble in ether and chloroform. Being heated to above 230 °C causes its decomposition into trimethylamine and methyl chloride. Median lethal dose (mice, intraperitoneal) is around 25mg/kg. It is also used for the synthesis of liquid crystal epoxy compound, and Pope and polarographic analysis, as well as electronic industry.
The above information is edited by the chemicalbook of Dai Xiongfeng.

Electrolytic preparation of tetramethylammonium hydroxide

Tetramethylammonium hydroxide is a kind of organic base, and has a broad range of application in the field of both industry and scientific research.
In our own country, it is mainly used as the catalyst in the synthesis of organic silicon products, such as synthetic silicone oil, silicone rubber, and silicone resin. Although it has a low usage amount, but it can significantly affect both the yield and quality of the product.
In abroad, it is mainly used for polyester-based polymers, textiles, plastics, food, leather, wood processing, electroplating, and some kinds of microorganisms.
Now tetramethylammonium hydroxide has entered the advanced technology areas. For example, in the field of manufacturing industry of electronic circuit and microscopic sheets production, it can be used as the cleaning agent of integrated circuit board as well as the anisotropic corrosive agents of the Si-SiO2 interface in semiconductor microfabrication technique. With the development of science and technology, the requirements of this type of chemicals are also increasing, posing higher requirements for both the quality and the quantity of the tetramethylammonium hydroxide.
The basic principle of using electrolytic method for preparation of tetramethylammonium hydroxide is that the aqueous solution of tetramethylammonium chloride in the anode compartment of the electrolytic bath, under the action of the electric force, has its chloride ions migrate to the direction of anode until discharge of anode occurs to generate chlorine. Meanwhile, because of the selective permeability of the ion-exchange membrane, chloride can’t penetrate through the ion-exchange membrane through diffusion. Instead, only tetramethylammonium ions can selectively penetrate into the cathode compartment through, and be enriched over there. The water molecule in the electrolyzer cathode chamber is decomposed into hydrogen and hydroxyl ions. The latter one exactly binds to the tetramethylammonium ions migrated from the anode chamber to generate tetramethylammonium hydroxide. With the increase of electricity, tetramethylammonium hydroxide concentration continues to improve, finally achieving the desired final concentration of crude.
The anodic electrochemical reaction is:
(CH3) 4NCl → (CH3) 4N ++ Clˉ2Clˉ-2e → Cl2 ↑
The cathodic electrochemical reaction is:
H2O → H + + OHˉ (CH3) 4N ++ OHˉ → (CH3) 4NOH 2H ++ 2e → H2 ↑
The total reaction is:
2 (CH3) 4NCl + 2H2O → 2 (CH3) 4NOH + H2 ↑ + Cl2 ↑
The hydrogen generated during electrolysis is vented with the resulting chlorine absorbed by alkaline solution to generate sodium hypochlorite which is major raw materials for producing bleach.
Therefore, this method of producing tetramethylammonium hydroxide is simple with high purity and causing no environmental pollution.

The preparation of PHBHQ type thermoset Liquid crystalline epoxy resin (LCER)

Use toluene as the solvent, concentrated sulfuric acid and boric acid as the catalyst, add into the three-necked flask of equal amount of hydroxybenzoic acid and 1,4-hydroquinone, have reaction at 120~130 °C for 6 h; after cooling, repeatedly wash with distilled water, and obtain the p-hydroxybenzoic acid p-hydroquinone ester after vacuum dry (white solid, yield 87.5%).
Dissolve the above product in an excess amount of epichlorohydrin, further add tetramethylammonium chloride and have reaction at 60~70 °C for 10 h; add drop wise of excess amount of aqueous 45% NaOH solution (the addition takes 6 h). Excess amount epichlorohydrin was distilled off under reduced pressure; wash the reaction mixture with acetone-methanol mixed solution for crystallization; it is further subject to vacuum drying to obtain a white PHBHQ-type thermosetting liquid crystalline epoxy resin (with the yield being 37.5%). Mix PHBHQ and hardener stoichiometrically for heating and melting, casting with the curing process being 90 ℃ × 1h; 120 ℃ × 2h; 150 ℃ × 2h; 180 ℃ × 2h.

Uses

1. It can be used as polarographic analysis reagents which is widely used in the electronics industry.
2. Tetramethylammonium chloride is the phase transfer catalyst in organic synthesis with its catalytic activity being stronger than triphenylphosphine and triethylamine. At room temperature, it is a white crystalline powder, and is volatile, irritant, and easy to absorb moisture. It is easily soluble in methanol, soluble in water and hot ethanol but insoluble in ether and chloroform. Being heated to above 230 °C causes its decomposition into trimethylamine and methyl chloride. Median lethal dose (mice, intraperitoneal) is around 25mg/kg. It is also used for the synthesis of liquid crystal epoxy compound, and Pope and polarographic analysis, as well as electronic industry.

Chemical Properties

white crystals

Uses

Tetramethylammonium chloride along with N-hydroxyphthalimide and xanthone may be used as an efficient chloride catalytic system for the aerobic oxidation of hydrocarbons to form the corresponding oxygenated compounds. It may also be used as a phase transfer catalyst for the synthesis of aryl fluorides via selective chloride/fluoride exchange reaction of activated aryl chlorides with potassium fluoride in solid-liquid phase.

Uses

TMAC may be used in ion-exchange procedures to show the increase of pH in understanding the chemical behaviour of catalyst [CTA]Si-MCM-41 using Knoevenagel condensation model.

Uses

Chemical intermediate, catalyst, inhibitor.

Definition

ChEBI: N,N,N-Trimethylmethanaminium chloride is an organic molecular entity.

General Description

Tetramethylammonium chloride is a quaternary ammonium salt commonly used as a catalyst due to its thermal stability and also tolerance towards strong aqueous bases or nucleophiles.

Safety Profile

Poison by ingestion, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of NOx, NH3, and Cl-. See also CHLORIDES.

Purification Methods

Crystallise the chloride from EtOH, EtOH/CHCl3, EtOH/diethyl ether, acetone/EtOH (1:1), isopropanol or water. Traces of the free amine can be removed by washing with CHCl3. [Beilstein 4 IV 145.]

Tetramethylammonium chloride Preparation Products And Raw materials

Raw materials

Preparation Products

2,6-DICHLORO-4-ISOCYANATOPYRIDINE 4-FLUORO-2-NITROBENZONITRILE 2-Hydroxyethyl methacrylate
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View Lastest Price from Tetramethylammonium chloride manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Tetramethylammonium chloride 75-57-0
Price
US $999.00-800.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
5000
Release date
2024-08-20
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Tetramethylammonium chloride 75-57-0
Price
US $25.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-04-25
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Tetramethylammonium chloride 75-57-0
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-22

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