N-Hydroxy-5-norbornene-2,3-dicarboximide
- Product Name
- N-Hydroxy-5-norbornene-2,3-dicarboximide
- CAS No.
- 21715-90-2
- Chemical Name
- N-Hydroxy-5-norbornene-2,3-dicarboximide
- Synonyms
- HONB;N-HYDROXY-5-NORBORNENE-2,3-DICARBOXYLIC ACID IMIDE;2-Hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione;N-Hydroxy-5-norborne;LABOTEST-BB LT00112336;Endo-N-Hydroxy-5-Norbornene-2,;N-Hydroxynorborna-5-ene-2,3-dicarbimide;N-Hydroxy-5-Norborene-2,3-Dicarboximide;N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE;N-Hydroxy-5-norbornene-2,4-dicarboximide
- CBNumber
- CB9121858
- Molecular Formula
- C9H9NO3
- Formula Weight
- 179.17
- MOL File
- 21715-90-2.mol
N-Hydroxy-5-norbornene-2,3-dicarboximide Property
- Melting point:
- 165-170 °C (lit.)
- Boiling point:
- 311.69°C (rough estimate)
- Density
- 1.2822 (rough estimate)
- refractive index
- 1.5600 (estimate)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Soluble in ethanol
- pka
- 9.00±0.20(Predicted)
- form
- Solid
- color
- Off-White
- BRN
- 13540
- CAS DataBase Reference
- 21715-90-2(CAS DataBase Reference)
- EPA Substance Registry System
- 4,7-Methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-2-hydroxy- (21715-90-2)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 226378
- Product name
- N-Hydroxy-5-norbornene-2,3-dicarboxylic acid imide
- Purity
- 97%
- Packaging
- 50g
- Price
- $203
- Updated
- 2024/03/01
- Product number
- H0528
- Product name
- N-Hydroxy-5-norbornene-2,3-dicarboximide [for Peptide Synthesis]
- Purity
- >99.0%(T)
- Packaging
- 25g
- Price
- $34
- Updated
- 2024/03/01
- Product number
- H0528
- Product name
- N-Hydroxy-5-norbornene-2,3-dicarboximide [for Peptide Synthesis]
- Purity
- >99.0%(T)
- Packaging
- 250g
- Price
- $185
- Updated
- 2024/03/01
- Product number
- A13205
- Product name
- endo-N-Hydroxy-5-norbornene-2,3-dicarboximide, 97%
- Packaging
- 10g
- Price
- $33.65
- Updated
- 2024/03/01
- Product number
- A13205
- Product name
- endo-N-Hydroxy-5-norbornene-2,3-dicarboximide, 97%
- Packaging
- 50g
- Price
- $125.65
- Updated
- 2024/03/01
N-Hydroxy-5-norbornene-2,3-dicarboximide Chemical Properties,Usage,Production
Description
N-Hydroxy-5-norbornene-2,3-dicarboximide (NHD) is a compound that has antiviral activity and is used to treat HIV infections. It inhibits the reverse transcriptase enzyme in the virus, which blocks the synthesis of viral DNA. The ferroelectric properties of NHD were first observed by observing changes in its melting point when mixed with water. This property makes it useful for diagnosis purposes. In animal studies, a dose of 5 mg/kg was found to be effective against cancer cells and the drug showed no toxicity in humans at doses up to 500 mg/day. The optimal reaction conditions for NHD are pH 6 and temperature 45 degrees Celsius.
Chemical Properties
white to off-white crystalline powder
Uses
Inhibits racemization in peptide synthesis using DCC as condensing agent.
Uses
N-Hydroxy-5-norbornene-2,3-dicarboximide(HONB) is used in solution-phase peptide synthesis. Used in the synthesis of enkephalin analogs.
Uses
It decreases racemization in peptide synthesis and inhibits formation of N-acylureas.
Purification Methods
Dissolve the imide in CHCl3, filter, evaporate and recrystallise from EtOAc. IR (nujol): max 1695, 1710 and 1770 (C=O), and 3100 (OH) cm-1. The O-acetyl derivative has m 113-114o (from EtOH) with IR bands at max 1730, 1770 and 1815 cm-1 only, and the O-benzoyl derivative has m 143-144o (from propan-2-ol or *C6H6). [Bauer & Miarka J Org Chem 24 1293 1959, Fujino et al. Chem Pharm Bull Jpn 22 1857 1974]. [Beilstein 21/10 V 188.]
N-Hydroxy-5-norbornene-2,3-dicarboximide Preparation Products And Raw materials
Raw materials
Preparation Products
N-Hydroxy-5-norbornene-2,3-dicarboximide Suppliers
- Tel
- --
- Fax
- --
- info@trc-canada.com
- Country
- Canada
- ProdList
- 6038
- Advantage
- 71
View Lastest Price from N-Hydroxy-5-norbornene-2,3-dicarboximide manufacturers
- Product
- N-Hydroxy-5-norbornene-2,3-dicarboximide 21715-90-2
- Price
- US $0.00-0.00/G
- Min. Order
- 1G
- Purity
- 99.9%
- Supply Ability
- 20ton
- Release date
- 2023-02-27
- Product
- N-Hydroxy-5-norbornene-2,3-dicarboximide 21715-90-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-26
- Product
- N-Hydroxy-5-norbornene-2,3-dicarboximide 21715-90-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5000kg/month
- Release date
- 2021-10-20