N-Hydroxy-5-norbornene-2,3-dicarboximide

ChemicalBook > CAS DataBase List > N-Hydroxy-5-norbornene-2,3-dicarboximide

N-Hydroxy-5-norbornene-2,3-dicarboximide

Product Name: N-Hydroxy-5-norbornene-2,3-dicarboximide
CAS No.: 21715-90-2
Chemical Name: N-Hydroxy-5-norbornene-2,3-dicarboximide
Synonyms: HONB;N-HYDROXY-5-NORBORNENE-2,3-DICARBOXYLIC ACID IMIDE;2-Hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione;N-Hydroxy-5-norborne;LABOTEST-BB LT00112336;Endo-N-Hydroxy-5-Norbornene-2,;N-Hydroxynorborna-5-ene-2,3-dicarbimide;N-Hydroxy-5-Norborene-2,3-Dicarboximide;N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE;N-Hydroxy-5-norbornene-2,4-dicarboximide
CBNumber: CB9121858
Molecular Formula: C9H9NO3
Formula Weight: 179.17
MOL File: 21715-90-2.mol

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N-Hydroxy-5-norbornene-2,3-dicarboximide Property

Melting point:: 165-170 °C (lit.)
Boiling point:: 311.69°C (rough estimate)
Density: 1.2822 (rough estimate)
refractive index: 1.5600 (estimate)
storage temp.: Sealed in dry,2-8°C
solubility: Soluble in ethanol
pka: 9.00±0.20(Predicted)
form: Solid
color: Off-White
BRN: 13540
CAS DataBase Reference: 21715-90-2(CAS DataBase Reference)
EPA Substance Registry System: 4,7-Methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-2-hydroxy- (21715-90-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
TSCA: Yes
HS Code: 29280090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 226378
Product name: N-Hydroxy-5-norbornene-2,3-dicarboxylic acid imide
Purity: 97%
Packaging: 50g
Price: $203
Updated: 2024/03/01

TCI Chemical

Product number: H0528
Product name: N-Hydroxy-5-norbornene-2,3-dicarboximide [for Peptide Synthesis]
Purity: >99.0%(T)
Packaging: 25g
Price: $34
Updated: 2024/03/01

TCI Chemical

Product number: H0528
Product name: N-Hydroxy-5-norbornene-2,3-dicarboximide [for Peptide Synthesis]
Purity: >99.0%(T)
Packaging: 250g
Price: $185
Updated: 2024/03/01

Alfa Aesar

Product number: A13205
Product name: endo-N-Hydroxy-5-norbornene-2,3-dicarboximide, 97%
Packaging: 10g
Price: $33.65
Updated: 2024/03/01

Alfa Aesar

Product number: A13205
Product name: endo-N-Hydroxy-5-norbornene-2,3-dicarboximide, 97%
Packaging: 50g
Price: $125.65
Updated: 2024/03/01

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N-Hydroxy-5-norbornene-2,3-dicarboximide Chemical Properties,Usage,Production

Description

N-Hydroxy-5-norbornene-2,3-dicarboximide (NHD) is a compound that has antiviral activity and is used to treat HIV infections. It inhibits the reverse transcriptase enzyme in the virus, which blocks the synthesis of viral DNA. The ferroelectric properties of NHD were first observed by observing changes in its melting point when mixed with water. This property makes it useful for diagnosis purposes. In animal studies, a dose of 5 mg/kg was found to be effective against cancer cells and the drug showed no toxicity in humans at doses up to 500 mg/day. The optimal reaction conditions for NHD are pH 6 and temperature 45 degrees Celsius.

Chemical Properties

white to off-white crystalline powder

Uses

Inhibits racemization in peptide synthesis using DCC as condensing agent.

Uses

N-Hydroxy-5-norbornene-2,3-dicarboximide(HONB) is used in solution-phase peptide synthesis. Used in the synthesis of enkephalin analogs.

Uses

It decreases racemization in peptide synthesis and inhibits formation of N-acylureas.

Purification Methods

Dissolve the imide in CHCl3, filter, evaporate and recrystallise from EtOAc. IR (nujol): max 1695, 1710 and 1770 (C=O), and 3100 (OH) cm-1. The O-acetyl derivative has m 113-114o (from EtOH) with IR bands at max 1730, 1770 and 1815 cm-1 only, and the O-benzoyl derivative has m 143-144o (from propan-2-ol or *C6H6). [Bauer & Miarka J Org Chem 24 1293 1959, Fujino et al. Chem Pharm Bull Jpn 22 1857 1974]. [Beilstein 21/10 V 188.]

N-Hydroxy-5-norbornene-2,3-dicarboximide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-Hydroxy-5-norbornene-2,3-dicarboximide manufacturers

Puyang Huicheng Electronic Materials Co., Ltd.

Product: N-Hydroxy-5-norbornene-2,3-dicarboximide 21715-90-2
Price: US $0.00-0.00/G
Min. Order: 1G
Purity: 99.9%
Supply Ability: 20ton
Release date: 2023-02-27

Henan Aochuang Chemical Co.,Ltd.

Product: N-Hydroxy-5-norbornene-2,3-dicarboximide 21715-90-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-26

Shanxi Naipu Import and Export Co.,Ltd

Product: N-Hydroxy-5-norbornene-2,3-dicarboximide 21715-90-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5000kg/month
Release date: 2021-10-20

21715-90-2, N-Hydroxy-5-norbornene-2,3-dicarboximideRelated Search:

Bismaleimide O-Phthalimide N-Chlorosuccinimide CHLOROPHOSPHONAZO III Dispersing agent 155 Succinimide HNTU 2-(5-Norborene-2,3-dicarboximido)-1,1,3,3-tetramethyluronium tetrafluoroborate Polyamideimide DIALIFOS 5-Norbornene-2,3-dicarboxylic acid 5-Norbornene-2-endo,3-exo-dicarboxylic acid EXO-NORBORNEOL Norbornene 5-NORBORNENE-2,3-DICARBOXIMIDE ENDO-N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE, 97 N-BENZYLOXYCARBONYLOXY-5-NORBORNENE-2,3-DICARBOXIMIDE, 99 N-Hydroxy-5-norbornene-2,3-dicarboximide

N-HYDROXY-5-NORBORNENE-2,3-DICARBOXYLIC ACID IMIDE

N-HYDROXY-5-NORBORNENE-2,3-DICARBOXYLIMIDE

N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE

N-HYDROXYBICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLIC ACID IMIDE

N-HYDROXYBICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXIMIDE

HONB

LABOTEST-BB LT00112336

3(2h)-dione,3a,4,7,7a-tetrahydro-2-hydroxy-7-methano-1h-isoindole-1

HONB, N-Hydroxybicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid imide

3a,4,7,7a-Tetrahydro-2-hydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione

4-Hydroxy-4-azatricyclo[5.2.1.02,6]deca-8-ene-3,5-dione

N-Hydroxybicyclo[2.2.1]hepta-5-ene-2,3-dicarbimide

N-Hydroxynorborna-5-ene-2,3-dicarbimide

N-Hydroxybicyclo[2.2.1]-5-heptene-2,3-dicarboxiMide

N-Hydroxy-5-norborne

2-Hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione

N-Hydroxy-5-norbornene-endo-2,3-dicarboximide97%

N-Hydroxy-5-norbornene-2,4-dicarboximide

N-Hydroxy-5-norbornene-2,3-dicarboxylic acid imide 97%

N-hydroxy-5-norbornene-2.3-dicarboxylimide(HONB)

N-Hydroxy-5-norbornene-2.3-dicarboxylic imide

endo-N-Hydroxybicyclo[2.2.1]hept-5-ene-2,3-dicarbo

Honb(N-Hydrozy-5-Norbornene-2.3-DicarboxylicImide)

N-Hydroxy-5-Norborene-2,3-Dicarboximide

N-Hydroxy-5-norbornene-2,3-dicarboximide, 99+%

Endo-N-Hydroxy-5-Norbornene-2,

HONB N-Hydroxy-5-norbornene-endo-2,3-dicarboximide N-Hydroxybicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid imide

HONB, endo-N-Hydroxy-5-norbornene-2,3-dicarboximide

ENDO-N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE HONB

HONB N-HYDROXY-5-NORBORNENE-2.3-DICARBOXYLIMIDE

N-HYDROXY-5-NORBORNENE-2,3-DICARBOXYLIC ACID IMIDE (HONB)

N-hydroxynorborn-5-ene-2,3-dicarboximide

N-Hydroxy-5-norbornene- 2,3-dicarboxylicacid imide,endo-N-Hydroxy-5- norbornene-2,3-dicarboximide

N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE (HONB)

N-HYDROXY-5-NORBONENE-2,3-DICARBOXYLIC IMIDE

N-Hydroxy-5-norbornene-2,3-dicarboximide [for Peptide Synthesis]

N-Hydroxy-5-norbornene-2,3-dicarboximide[forPeptideSynthesis]&gt

N-Hydroxy-5-norbornene-2,3-dicarboximide USP/EP/BP

TIANFU-CHEM 21715-90-2 N-Hydroxy-5-norbornene-2,3-dicarboximide

4-hydroxy-4-azatricyclo[5.2.1.02,]dec-8-ene-3,5-dione

N-Hydroxy-5-Norbornene-2,3-dimethylimide

21715-90-2

5C9H9NO3

Synthetic Reagents

Coupling

Coupling Reactions (Peptide Synthesis)

Peptide Synthesis

Condensation & Active Esterification

Active Esters/Additives

Coupling Reagent

Medical Intermediates

Biochemistry

Condensation & Active Esterification

Coupling Reactions (Peptide Synthesis)

Peptide Synthesis

Synthetic Organic Chemistry