HEMATOPORPHYRIN

Product Name: HEMATOPORPHYRIN
CAS No.: 14459-29-1
Chemical Name: HEMATOPORPHYRIN
Synonyms: hp;Ba1-647;Photodyn;NSC-59265;A-259H10.2;HEMATOPORPHYRIN;HAEMATOPORPHYRIN;HEMATOPORPHYRINE;hematoporphyrinix;HematoporphyrineBase
CBNumber: CB9134564
Molecular Formula: C34H38N4O6
Formula Weight: 598.69
MOL File: 14459-29-1.mol

More

Less

HEMATOPORPHYRIN Property

Melting point:: 172.5°C
Boiling point:: 649.58°C (rough estimate)
Density: 1.328
refractive index: 1.6000 (estimate)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO (Sparingly), Methanol (Slightly), Ethyl Acetate (Slightly)
form: Solid
color: Purple to Black
biological source: mouse
Merck: 13,4653
Stability:: Light Sensitive
EPA Substance Registry System: 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl- (14459-29-1)

More

Less

Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: TS5500000
F: 8-10-21

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SAB1411905
Product name: ANTI-HPR antibody produced in mouse
Purity: purified immunoglobulin, buffered aqueous solution
Packaging: 50 μg
Price: $541
Updated: 2025/07/31

TRC

Product number: H245678
Product name: Hematoporphyrin(TechnicalGrade,~30%)
Packaging: 500mg
Price: $175
Updated: 2021/12/16

Usbiological

Product number: 356334
Product name: HP
Packaging: 48Tests
Price: $588
Updated: 2021/12/16

Usbiological

Product number: 356327
Product name: HP
Packaging: 48Tests
Price: $588
Updated: 2021/12/16

Usbiological

Product number: 356330
Product name: HP
Packaging: 48Tests
Price: $588
Updated: 2021/12/16

More

Less

HEMATOPORPHYRIN Chemical Properties,Usage,Production

Chemical Properties

Red-purple crystals, soluble in ethanol, slightly soluble in ether and chloroform, insoluble in water.

Uses

antidepressant, antineoplastic

Uses

Hematoporphyrin (Photodyn, Sensibion) is a porphyrin prepared from hemin. It is a derivative of protoporphyrin IX, where the two vinyl groups have been hydrated (coverted to alcohols). It is used as a photosensitizer in photodynamic therapy. Acetylation of hematoporphyrin followed by hydrolysis of the product of that reaction affords a mixture called hematoporphyrin derivative (HPD), which is also used in photodynamic therapy. Hematoporphyrin has also been used as an antidepressant and antipsychotic since the 1920s.

Definition

ChEBI: A dicarboxylic acid that is protoporphyrin in which the vinyl groups at positions 7 and 12 are replaced by 1-hydroxyethyl groups.

Hazard

Toxic. Reported to be preferentially absorbed by cancerous tissues, making them fluoresce under UV light.

in vivo

Hematoporphyrin (5-10 mg/kg; i.p. for 2 months) with the irradiation of red light rapidly decreases the tumor size of rats, due to necrosis caused both by direct action of the photoactivated porphyrin on the tumor cells and by secondary effects on blood vessels^[3].

Animal Model:	Wistar albino rats of both sexes (20 d; 60-80 g) bearing a subcutaneous solid Yoshida hepatoma AH-130^[3]
Dosage:	5, 10 mg/kg
Administration:	I.p. daily during the initial 10 days and biweekly for the next 2 months
Result:	No tumor could be palpated a few days after exposure of the rats to light. The skin healed completely and regrowth of the hair occurred. Massive coagulation necrosis of the tumor 24 h after phototreatment (×40).

IC 50

Human Endogenous Metabolite

Purification Methods

Purify it by dissolving it in EtOH Hematoporphyrin and adding H2O or Et2O to give deep red crystals. It has also been recrystallised from MeOH. UV has max at 615.5, 565, 534.4 and 499.5nm in 0.1N NaOH, and 597, 619, 634, 653, 683 and 701nm in 2N HCl [Falk Porphyrins and Metalloporphyrins Elsevier, NY, p 175 1964, LCCCNo 63-19821.] It is used in the affinity chromatographic purification of Heme proteins [Olsen Methods Enzymol 123 324 1986]. The O-methyl-dimethyl ester has m 203-206o (from CHCl3/MeOH), and the O,O'-dimethyl-dimethyl ester has m 145o (from CHCl3/MeOH). [Paul Acta Chem Scand 5 389 1951, Beilstein 26 III/IV 3157, and 3158 for the HCl.]

HEMATOPORPHYRIN Preparation Products And Raw materials

Raw materials

Hemin

Preparation Products

More

Less

HEMATOPORPHYRIN Suppliers

China 75 Europe 2 Germany 3 Japan 1 Switzerland 1 United Kingdom 7 United States 22 Global 111

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354;
Email: support@targetmol.com
Country: United States
ProdList: 39035
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 52923
Advantage: 58

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

RIA International LLC

Tel: --
Fax: --
Email: marketing@riausa.net
Country: United States
ProdList: 1324
Advantage: 50

Advance Scientific & Chemical

Tel: --
Fax: --
Email: sales@advance-scientific.com
Country: United States
ProdList: 6419
Advantage: 71

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

City Chemical LLC

Tel: --
Fax: --
Email: sales@citychemical.com
Country: United States
ProdList: 6708
Advantage: 72

ChromaDex

Tel: --
Fax: --
Email: sales@chromadex.com
Country: United States
ProdList: 2501
Advantage: 76

Frontier Scientific, Inc.

Tel: --
Fax: --
Email: sales@frontiersci.com
Country: United States
ProdList: 6222
Advantage: 86

City Chemicals Corporation

Tel: --
Fax: --
Country: United States
ProdList: 6460
Advantage: 72

Eastern Chemical Corp.

Tel: --
Fax: --
Email: eastern@u-g.com
Country: United States
ProdList: 2786
Advantage: 34

Pfaltz & Bauer, Inc.

Tel: --
Fax: --
Email: sales@pfaltzandbauer.com
Country: United States
ProdList: 6828
Advantage: 72

Spectrum Chemicals & Laboratory Products

Tel: --
Fax: --
Email: sales@spectrumchemical.com
Country: United States
ProdList: 6699
Advantage: 77

MP Biomedicals, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 6561
Advantage: 81

More

Less

View Lastest Price from HEMATOPORPHYRIN manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Hematoporphyrin 14459-29-1
Price: US $18.00-48.00/KG
Min. Order: 0.01KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-19

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Hematoporphyrin 14459-29-1
Price: US $60.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-06-04

airuikechemical co., ltd.

Product: Hematoporphyrin 14459-29-1
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 20 tons
Release date: 2024-03-29

14459-29-1, HEMATOPORPHYRINRelated Search:

HEMATOPORPHYRIN DIHYDROCHLORIDE,HEMATOPORPHYRIN IX DIHYDROCHLORIDE (Z)-Hex-4-en-1-ol 3-PENTEN-2-OL HEMATOPORPHYRIN 3-BUTEN-2-OL Allylacetic acid 3-Methyl-2-buten-1-ol 4-Penten-1-ol (E)-4-Hexen-1-ol 4-HEXENOIC ACID 3-METHYLPYRROLE PORPHINE HEMATOPORPHYRIN IX DIMETHYL ESTER 4-METHYL-3-PENTEN-2-OL 3,4-DIMETHYLPYRROLE 3-METHYL-3-BUTEN-2-OL 5-METHYL-4-HEXENOIC ACID 3-ETHYL-1H-PYRROLE

1,3,5,8-tetramethyl-2,4-bis(alpha-hydroxyethyl)prophine-6,7-dipropionicacid

21h,23h-porphine-2,18-dipropanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-te

7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-18-porphinedipropionicacid

hematoporphyrinix

ANTI-HPR antibody produced in mouse

7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H,23H-Porphine-2,18-dipropanoic acid

7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H,23H-porphyrin-2,18-dipropionic acid

NSC-59265

Photodyn

3-[18-(2-carboxyethyl)-7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-22,23-dihydroporphin-2-yl]propionic acid

3-[18-(2-carboxyethyl)-7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoic acid

1,3,5,8-Tetramethyl-2,4-bis(α-hydroxyethyl)porphine-6,7-dipropionic acid

HeMatoporphyrin >=45%

hp

8,13-BIS(1-HYDROXYETHYL)-3,7,12,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONIC ACID

HAEMATOPORPHYRIN

HEMATOPORPHYRIN

HEMATOPORPHYRINE

HEMATOPORPHYRIN IX BASE

hematoporphyrin free base

HematoporphyrineBase

21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-

A-259H10.2

Hematoporphyrin (Technical Grade, ~30%)

Recombinant Human Haptoglobin/HP Protein, His Tag

Recombinant Human Haptoglobin/HP/HP Protein, His Tag

HEMATOPORPHYRIN USP/EP/BP

Hematoprophyrin USP/EP/BP

Hematoporphyrin Base

Ba1-647

14459-29-1

14459-21-1

C34H38N4O6

BioChemical

Biochemicals and Reagents

Natural Dyes

Proteins and Derivatives

Plasma, Blood, and Related Proteins and Reagents

Plasma & Blood Proteins