ChemicalBook > CAS DataBase List > HEMATOPORPHYRIN

HEMATOPORPHYRIN

Product Name
HEMATOPORPHYRIN
CAS No.
14459-29-1
Chemical Name
HEMATOPORPHYRIN
Synonyms
hp;Photodyn;NSC-59265;A-259H10.2;HEMATOPORPHYRIN;HAEMATOPORPHYRIN;HEMATOPORPHYRINE;hematoporphyrinix;HematoporphyrineBase;Hematoporphyrin Base
CBNumber
CB9134564
Molecular Formula
C34H38N4O6
Formula Weight
598.69
MOL File
14459-29-1.mol
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HEMATOPORPHYRIN Property

Melting point:
172.5°C
Boiling point:
649.58°C (rough estimate)
Density 
1.328
refractive index 
1.6000 (estimate)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO (Sparingly), Methanol (Slightly), Ethyl Acetate (Slightly)
form 
Solid
color 
Purple to Black
biological source
mouse
Merck 
13,4653
Stability:
Light Sensitive
EPA Substance Registry System
21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl- (14459-29-1)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
TS5500000
8-10-21
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
H245678
Product name
Hematoporphyrin(TechnicalGrade,~30%)
Packaging
500mg
Price
$175
Updated
2021/12/16
Usbiological
Product number
356334
Product name
HP
Packaging
48Tests
Price
$588
Updated
2021/12/16
Usbiological
Product number
356327
Product name
HP
Packaging
48Tests
Price
$588
Updated
2021/12/16
Usbiological
Product number
356330
Product name
HP
Packaging
48Tests
Price
$588
Updated
2021/12/16
Usbiological
Product number
383280
Product name
HP
Packaging
96Tests
Price
$599
Updated
2021/12/16
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HEMATOPORPHYRIN Chemical Properties,Usage,Production

Uses

antidepressant, antineoplastic

Uses

Hematoporphyrin (Photodyn, Sensibion) is a porphyrin prepared from hemin. It is a derivative of protoporphyrin IX, where the two vinyl groups have been hydrated (coverted to alcohols). It is used as a photosensitizer in photodynamic therapy. Acetylation of hematoporphyrin followed by hydrolysis of the product of that reaction affords a mixture called hematoporphyrin derivative (HPD), which is also used in photodynamic therapy. Hematoporphyrin has also been used as an antidepressant and antipsychotic since the 1920s.

Definition

ChEBI: A dicarboxylic acid that is protoporphyrin in which the vinyl groups at positions 7 and 12 are replaced by 1-hydroxyethyl groups.

Hazard

Toxic. Reported to be preferentially absorbed by cancerous tissues, making them fluoresce under UV light.

Purification Methods

Purify it by dissolving it in EtOH Hematoporphyrin and adding H2O or Et2O to give deep red crystals. It has also been recrystallised from MeOH. UV has max at 615.5, 565, 534.4 and 499.5nm in 0.1N NaOH, and 597, 619, 634, 653, 683 and 701nm in 2N HCl [Falk Porphyrins and Metalloporphyrins Elsevier, NY, p 175 1964, LCCCNo 63-19821.] It is used in the affinity chromatographic purification of Heme proteins [Olsen Methods Enzymol 123 324 1986]. The O-methyl-dimethyl ester has m 203-206o (from CHCl3/MeOH), and the O,O'-dimethyl-dimethyl ester has m 145o (from CHCl3/MeOH). [Paul Acta Chem Scand 5 389 1951, Beilstein 26 III/IV 3157, and 3158 for the HCl.]

HEMATOPORPHYRIN Preparation Products And Raw materials

Raw materials

Preparation Products

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HEMATOPORPHYRIN Suppliers

MedChemexpress LLC
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021-58955995
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609-228-5909
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Musechem
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+1-800-259-7612
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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TargetMol Chemicals Inc.
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support@targetmol.com
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Aladdin Scientific
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Matrix Scientific
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View Lastest Price from HEMATOPORPHYRIN manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Hematoporphyrin 14459-29-1
Price
US $60.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-06-04
airuikechemical co., ltd.
Product
Hematoporphyrin 14459-29-1
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
20 tons
Release date
2024-03-29
Dideu Industries Group Limited
Product
Hematoprophyrin
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-26

14459-29-1, HEMATOPORPHYRINRelated Search:


  • 1,3,5,8-tetramethyl-2,4-bis(alpha-hydroxyethyl)prophine-6,7-dipropionicacid
  • 21h,23h-porphine-2,18-dipropanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-te
  • 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-18-porphinedipropionicacid
  • hematoporphyrinix
  • ANTI-HPR antibody produced in mouse
  • 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H,23H-Porphine-2,18-dipropanoic acid
  • 7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H,23H-porphyrin-2,18-dipropionic acid
  • NSC-59265
  • Photodyn
  • 3-[18-(2-carboxyethyl)-7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-22,23-dihydroporphin-2-yl]propionic acid
  • 3-[18-(2-carboxyethyl)-7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoic acid
  • 1,3,5,8-Tetramethyl-2,4-bis(α-hydroxyethyl)porphine-6,7-dipropionic acid
  • HeMatoporphyrin >=45%
  • hp
  • 8,13-BIS(1-HYDROXYETHYL)-3,7,12,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONIC ACID
  • HAEMATOPORPHYRIN
  • HEMATOPORPHYRIN
  • HEMATOPORPHYRINE
  • HEMATOPORPHYRIN IX BASE
  • hematoporphyrin free base
  • HematoporphyrineBase
  • 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-
  • A-259H10.2
  • Hematoporphyrin (Technical Grade, ~30%)
  • Recombinant Human Haptoglobin/HP Protein, His Tag
  • Recombinant Human Haptoglobin/HP/HP Protein, His Tag
  • HEMATOPORPHYRIN USP/EP/BP
  • Hematoprophyrin USP/EP/BP
  • Hematoporphyrin Base
  • 14459-29-1
  • 14459-21-1
  • C34H38N4O6
  • BioChemical
  • Biochemicals and Reagents
  • Natural Dyes
  • Proteins and Derivatives
  • Plasma, Blood, and Related Proteins and Reagents
  • Plasma & Blood Proteins