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Levocetirizine dihydrochloride

Product Name
Levocetirizine dihydrochloride
CAS No.
130018-87-0
Chemical Name
Levocetirizine dihydrochloride
Synonyms
DDDB;LevocetrizineHCl;LEVOCETIRIZINE HCL;Levocetirizine HCI;LEVOCETIRIZINE 2HCL;Levocitirizine 2HCL;LEVOCETIRIZINE DIHCL;(R)-Cetirizine DiHCl;Xyzal Dihydrochloride;(R)-Form dihydrochloride
CBNumber
CB9135031
Molecular Formula
C21H27Cl3N2O3
Formula Weight
461.81
MOL File
130018-87-0.mol
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Levocetirizine dihydrochloride Property

Melting point:
215-220°C
alpha 
D25 -12.79° (c = 1 in water)
storage temp. 
room temp
solubility 
H2O: ≥23mg/mL
form 
powder
color 
White to Almost white
Merck 
14,2022
Stability:
Hygroscopic
CAS DataBase Reference
130018-87-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-50/53
Safety Statements 
60-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
AG0990000
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L7795
Product name
Levocetirizine dihydrochloride
Purity
≥98% (HPLC)
Packaging
10mg
Price
$97.2
Updated
2024/03/01
Sigma-Aldrich
Product number
L7795
Product name
Levocetirizine dihydrochloride
Purity
≥98% (HPLC)
Packaging
50mg
Price
$376
Updated
2024/03/01
TCI Chemical
Product number
L0264
Product name
Levocetirizine Dihydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$101
Updated
2024/03/01
TCI Chemical
Product number
L0264
Product name
Levocetirizine Dihydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$304
Updated
2024/03/01
Cayman Chemical
Product number
23992
Product name
(R)-Cetirizine (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$68
Updated
2024/03/01
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Levocetirizine dihydrochloride Chemical Properties,Usage,Production

Uses

Anti Histaminic

Uses

Levocetirizine dihydrochloride has been used as standard in the thin layer chromatography optimization and in preparation of racemic cetirizine standard for subcritical fluid chromatography-tandem mass spectrometry analysis.

General Description

Levocetirizine dihydrochloride,(R)-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl] ethoxy] acetic acid dihydrochloride, (Xyzal) is awhite, crystalline powder and is water soluble. ThisR-enantiomer is has a 30-fold higher affinity than the S-enantiomer,and dissociates more slowly from H1-receptors.Pharmacologically, it displays the same receptor and CNSselecitivity profile as the racemate, cetirizine,and thus the same therapeutic advantages. Levocetirizine isindicated for the relief of symptoms associated with allergicrhinitis (seasonal and perennial) in adults and children 6 yearsof age and older and for the treatment of the uncomplicatedskin manifestations of chronic idiopathic urticaria in adultsand children 6 years of age and older. Its pharmacokineticsand clearance profile are essentially the same as the racemate,cetirizine .

Biochem/physiol Actions

Levocetirizine hydrochloride is a nonsedating antihistamine. It is a histamine H1-receptor antagonist, the active isomer of cetirizine. Levocetirizine has high bioavailability, high affinity for and occupancy of the H1 receptor.

Levocetirizine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Levocetirizine dihydrochloride Suppliers

Americas 1 Austria 1 Belgium 1 Canada 1 China 289 Europe 3 France 1 Germany 5 India 149 Israel 1 Japan 1 Nepal 1 South Korea 4 United Arab Emirates 1 United Kingdom 13 United States 45 Global 517
CHEMOS GmbH & Co. KG
Tel
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Fax
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Email
chemos@chemos.de
Country
Germany
ProdList
6727
Advantage
58
BIOTREND Chemikalien GmbH
Tel
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Email
jaeger@biotrend.com
Country
Germany
ProdList
6115
Advantage
76
cfm Oskar Tropitzsch
Tel
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Fax
--
Country
Germany
ProdList
1136
Advantage
62
PARAGOS
Tel
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Fax
--
Email
info@paragos.com
Country
Germany
ProdList
6371
Advantage
39
Service Chemical Inc.
Tel
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Fax
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Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from Levocetirizine dihydrochloride manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Levocetirizine dihydrochloride 130018-87-0
Price
US $100.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-04-24
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Levocetirizine dihydrochloride 130018-87-0
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
98.0%~102.0%; USP41
Supply Ability
1500kg/month
Release date
2021-06-03
Hebei Yanxi Chemical Co., Ltd.
Product
Levocetirizine dihydrochloride 130018-87-0
Price
US $50.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2023-09-19

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  • LEVOCITIRIZINE DIHYDROCHLORIDE
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  • (2-(4-[(R)-(4-Chlorophenyl)(phenyl)methyl]piperazin-1-yl)ethoxy)acetic acid dihydrochloride
  • Levocitirizine 2HCL
  • (R)-Cetirizine diHCl (Levocetirizine diHCl)
  • Levocetirizine dihydrochloride [2-[4-[(R)-(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid dihydrochloride
  • 2-[2-[4-[(R)-(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride
  • DDDB
  • Cetirizine hydrochloride sinistral
  • (R)-Form dihydrochloride
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  • Levocetirizine Dihydrochloride (1359969)
  • (-)-Cetirizine Dihydrochloride
  • Xyzal Dihydrochloride
  • (R)-Cetirizine DiHCl
  • Levocetirizine HCI
  • LEVOCETIRIZINE HYDROCHLORIDE IP
  • Levocetirizine dihydrochloride IMpurity
  • Levocetirizine Dihydrochloride, ≥ 98.0%
  • Levocetirizine Dihydrochloride -IHS/IPS
  • 130018-87-0
  • 3008-87-0
  • C21H25ClN2O32ClH
  • Antibiotics
  • Levocitirizine 2HCl
  • API
  • Histamine receptor
  • API's
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