ChemicalBook > CAS DataBase List > 1-N-Boc-3-Cyanopyrrolidine

1-N-Boc-3-Cyanopyrrolidine

Product Name
1-N-Boc-3-Cyanopyrrolidine
CAS No.
476493-40-0
Chemical Name
1-N-Boc-3-Cyanopyrrolidine
Synonyms
TERT-BUTYL 3-CYANOPYRROLIDINE-1-CARBOXYLATE;N-Boc-3-cyanopyrrolidine;1-Boc-3-cyanopyrrolidine;N-1-BOC-3-CYANOPYRROLIDINE;1-N-BOC-3-CYANO-PYRROLIDINE;1,1-Dimethylethyl 3-cyano-1-pyrrolidinecarboxylate;3-CYANO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Pyrrolidinecarboxylic acid, 3-cyano-, 1,1-dimethylethyl ester
CBNumber
CB9135859
Molecular Formula
C10H16N2O2
Formula Weight
196.25
MOL File
476493-40-0.mol
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1-N-Boc-3-Cyanopyrrolidine Property

Boiling point:
307.9±35.0 °C(Predicted)
Density 
1.08±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
-3.73±0.40(Predicted)
form 
solid
color 
Pale yellow
CAS DataBase Reference
476493-40-0(CAS DataBase Reference)
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Safety

Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36/37/39
RIDADR 
3439
HazardClass 
6.1
PackingGroup 
III
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B646200
Product name
1-N-Boc-3-cyanopyrrolidine
Packaging
250mg
Price
$70
Updated
2021/12/16
TRC
Product number
B646200
Product name
1-N-Boc-3-cyanopyrrolidine
Packaging
1g
Price
$150
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
37600
Product name
1-N-Boc-3-Cyanopyrrolidine
Packaging
1g
Price
$400
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140623
Product name
tert-Butyl 3-cyanopyrrolidine-1-carboxylate
Packaging
10g
Price
$450
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-696
Product name
tert-Butyl 3-cyanopyrrolidine-1-carboxylate
Purity
97.0%
Packaging
5G
Price
$540
Updated
2021/12/16
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1-N-Boc-3-Cyanopyrrolidine Chemical Properties,Usage,Production

Uses

1-N-Boc-3-cyanopyrrolidine is used to prepare aroyl-substituted pyrrolidines with monoamine reuptake inhibition activities.

Synthesis

773837-37-9

141699-57-2

476493-40-0

A solution was prepared from tert-butyl 3-(methylsulfonyloxy)pyrrolidine-1-carboxylate (2.65 g, 10 mmol) and sodium cyanide (2.5 g, 50 mmol) in N,N-dimethylformamide (100 mL). The reaction mixture was stirred at 100°C for 16 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was poured into water and extracted with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated saline and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure and the resulting residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate=5:1) to afford 1-N-Boc-3-cyanopyrrolidine (1.92 g, 98% yield).

References

[1] Patent: CN107474024, 2017, A. Location in patent: Paragraph 0385; 0392; 0393; 0394
[2] Patent: WO2017/211759, 2017, A1. Location in patent: Page/Page column 59; 60

1-N-Boc-3-Cyanopyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-N-Boc-3-Cyanopyrrolidine manufacturers

Career Henan Chemical Co
Product
1-N-Boc-3-Cyanopyrrolidine 476493-40-0
Price
US $0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
150KG
Release date
2019-07-01

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