1-N-Boc-3-Cyanopyrrolidine
- Product Name
- 1-N-Boc-3-Cyanopyrrolidine
- CAS No.
- 476493-40-0
- Chemical Name
- 1-N-Boc-3-Cyanopyrrolidine
- Synonyms
- TERT-BUTYL 3-CYANOPYRROLIDINE-1-CARBOXYLATE;N-Boc-3-cyanopyrrolidine;1-Boc-3-cyanopyrrolidine;N-1-BOC-3-CYANOPYRROLIDINE;1-N-BOC-3-CYANO-PYRROLIDINE;1,1-Dimethylethyl 3-cyano-1-pyrrolidinecarboxylate;3-CYANO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Pyrrolidinecarboxylic acid, 3-cyano-, 1,1-dimethylethyl ester
- CBNumber
- CB9135859
- Molecular Formula
- C10H16N2O2
- Formula Weight
- 196.25
- MOL File
- 476493-40-0.mol
1-N-Boc-3-Cyanopyrrolidine Property
- Boiling point:
- 307.9±35.0 °C(Predicted)
- Density
- 1.08±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -3.73±0.40(Predicted)
- form
- solid
- color
- Pale yellow
- CAS DataBase Reference
- 476493-40-0(CAS DataBase Reference)
Safety
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36/37/39
- RIDADR
- 3439
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B646200
- Product name
- 1-N-Boc-3-cyanopyrrolidine
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- B646200
- Product name
- 1-N-Boc-3-cyanopyrrolidine
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 37600
- Product name
- 1-N-Boc-3-Cyanopyrrolidine
- Packaging
- 1g
- Price
- $400
- Updated
- 2021/12/16
- Product number
- FB140623
- Product name
- tert-Butyl 3-cyanopyrrolidine-1-carboxylate
- Packaging
- 10g
- Price
- $450
- Updated
- 2021/12/16
- Product number
- 4H56-1-696
- Product name
- tert-Butyl 3-cyanopyrrolidine-1-carboxylate
- Purity
- 97.0%
- Packaging
- 5G
- Price
- $540
- Updated
- 2021/12/16
1-N-Boc-3-Cyanopyrrolidine Chemical Properties,Usage,Production
Uses
1-N-Boc-3-cyanopyrrolidine is used to prepare aroyl-substituted pyrrolidines with monoamine reuptake inhibition activities.
Synthesis
773837-37-9
141699-57-2
476493-40-0
A solution was prepared from tert-butyl 3-(methylsulfonyloxy)pyrrolidine-1-carboxylate (2.65 g, 10 mmol) and sodium cyanide (2.5 g, 50 mmol) in N,N-dimethylformamide (100 mL). The reaction mixture was stirred at 100°C for 16 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was poured into water and extracted with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated saline and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure and the resulting residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate=5:1) to afford 1-N-Boc-3-cyanopyrrolidine (1.92 g, 98% yield).
References
[1] Patent: CN107474024, 2017, A. Location in patent: Paragraph 0385; 0392; 0393; 0394
[2] Patent: WO2017/211759, 2017, A1. Location in patent: Page/Page column 59; 60
1-N-Boc-3-Cyanopyrrolidine Preparation Products And Raw materials
Raw materials
Preparation Products
1-N-Boc-3-Cyanopyrrolidine Suppliers
- Tel
- --
- Fax
- --
- export@ecochem.dk
- Country
- Europe
- ProdList
- 6371
- Advantage
- 66
- Tel
- --
- Fax
- --
- Sales@kemikalieimport.dk
- Country
- Europe
- ProdList
- 6685
- Advantage
- 47
View Lastest Price from 1-N-Boc-3-Cyanopyrrolidine manufacturers
- Product
- 1-N-Boc-3-Cyanopyrrolidine 476493-40-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-01