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Efaproxiral

Product Name
Efaproxiral
CAS No.
131179-95-8
Chemical Name
Efaproxiral
Synonyms
Efaproxyn;faproxiral;Efaproxiral;EFAPROXIRALUM;Efaproxiral (RSR13);Efaproxiral free acid;EFAPROXIRAL;EFAPROXIRAL FREE ACID;FAPROXIRAL;2-[4-(3,5-Dimethylphenylcarbamoylmethyl)phenoxy]-2-methylpropionic acid;2-(4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid;Propanoic acid, 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl-
CBNumber
CB91359078
Molecular Formula
C20H22NO4.Na
Formula Weight
341.4
MOL File
131179-95-8.mol
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Efaproxiral Property

Melting point:
48-50°C
Boiling point:
554.5±50.0 °C(Predicted)
Density 
1.202±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
3.26±0.10(Predicted)
color 
Off-White to Tan
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28294
Product name
Efaproxiral
Packaging
100mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
28294
Product name
Efaproxiral
Packaging
1g
Price
$535
Updated
2024/03/01
Cayman Chemical
Product number
28294
Product name
Efaproxiral
Packaging
250mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
28294
Product name
Efaproxiral
Packaging
500mg
Price
$302
Updated
2024/03/01
TRC
Product number
E415000
Product name
Efaproxiral
Packaging
250mg
Price
$175
Updated
2021/12/16
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Efaproxiral Chemical Properties,Usage,Production

Description

Efaproxiral is an allosteric hemoglobin (Hb) modifier that reduces the affinity of Hb for oxygen, increasing the diffusion of oxygen from blood to tissue. In isolated human whole blood, efaproxiral (1.75 mM) increases the partial pressure of oxygen at which Hb is 50% saturated (p50) from 26.75 to 38.63 mm Hg and decreases the percent oxyhemoglobin (Hb-O2) saturation from 48 to 33.8% at a partial oxygen pressure (pO2) of 26 mm Hg. Efaproxiral (150 mg/kg) increases tumor pO2 from 5.2 to 13.1 mm Hg 30 minutes after administration in a RIF-1 mouse fibrosarcoma flank tumor model. Efaproxiral (100 μM) enhances radiation-induced cytotoxicity in EMT6 mouse breast cancer cells grown under hypoxic conditions and increases radiosensitization and inhibits tumor growth in a hypoxic Lewis lung tumor mouse model when administered at a dose of 100 mg/kg. It also increases the running capacity of normal mice and mice with left coronary artery (LCA) ligation-induced myocardial infarction (MI) when administered at a dose of 150 mg/kg.

Chemical Properties

Off-White to Tan Solid

Uses

Allosteric modifier of hemoglobin (HB). Binds in the central water cavity of the Hb molecule causing a conformational change such that bound oxygen is released more readily. Antineoplastic adjunct (radiosensitizer).

Efaproxiral Preparation Products And Raw materials

Raw materials

Preparation Products

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Efaproxiral Suppliers

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J & K SCIENTIFIC LTD.
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View Lastest Price from Efaproxiral manufacturers

Career Henan Chemical Co
Product
Efaproxiral 131179-95-8
Price
US $1.00/KG
Min. Order
1KG
Purity
95--99%
Supply Ability
1ton
Release date
2020-01-03

131179-95-8, EfaproxiralRelated Search:

N,N-Dimethyl-1,4-phenylenediamine Dimethylcarbamoyl chloride Folic acid Chlorodimethylphenylsilane POLY(PROPYLENE-CO-ETHYLENE) DIMETHYLAMINOPYRIDINE, POLYMER-BOUND phenoxybenzamine Efaproxiral sodium Diethoxydimethylsilane β-Alanine Dimethyldimethoxysilane Ascoric Acid EPDM RUBBER Phenoxyacetic acid sodium salt AKOS B013930 2-methyl-2-(4-methylphenoxy)propanoic acid 2-(4-HYDROXY-PHENYL)-N-PHENYL-ACETAMIDE 4-METHOXY-N-PHENYL-BENZENEETHANAMINE

  • EFAPROXIRAL;EFAPROXIRAL FREE ACID;FAPROXIRAL
  • 2-(4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid
  • Efaproxiral
  • Efaproxiral free acid
  • faproxiral
  • EFAPROXIRALUM
  • 2-[4-(3,5-Dimethylphenylcarbamoylmethyl)phenoxy]-2-methylpropionic acid
  • Propanoic acid, 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl-
  • Efaproxiral (RSR13)
  • Efaproxyn
  • 131179-95-8
  • C20H22NO4Na
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals