ChemicalBook > CAS DataBase List > kazinol B

kazinol B

Product Name
kazinol B
CAS No.
99624-27-8
Chemical Name
kazinol B
Synonyms
kazinol B;Aids096026;Aids-096026;6-[(2S)-7-hydroxy-3,4-dihydro-2H-chromen-2-yl]-2,2-dimethyl-7-(3-methylbut-2-enyl)chromen-8-ol;[2,6'-Bi-2H-1-benzopyran]-7,8'-diol, 3,4-dihydro-2',2'-dimethyl-7'-(3-methyl-2-buten-1-yl)-, (2S)-
CBNumber
CB91360139
Molecular Formula
C25H28O4
Formula Weight
392.49
MOL File
99624-27-8.mol
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kazinol B Property

solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
InChI
InChI=1S/C25H28O4/c1-15(2)5-9-19-20(13-17-11-12-25(3,4)29-24(17)23(19)27)21-10-7-16-6-8-18(26)14-22(16)28-21/h5-6,8,11-14,21,26-27H,7,9-10H2,1-4H3/t21-/m0/s1
InChIKey
QSCBHDIGHKHWKC-NRFANRHFSA-N
SMILES
[C@H]1(C2C=C3C(=C(O)C=2C/C=C(/C)\C)OC(C)(C)C=C3)OC2=CC(O)=CC=C2CC1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FK159345
Product name
Kazinol B
Packaging
1mg
Price
$300
Updated
2021/12/16
Biosynth Carbosynth
Product number
FK159345
Product name
Kazinol B
Packaging
2mg
Price
$500
Updated
2021/12/16
AK Scientific
Product number
W2781
Product name
KazinolB
Packaging
2mg
Price
$725
Updated
2021/12/16
Biosynth Carbosynth
Product number
FK159345
Product name
Kazinol B
Packaging
5mg
Price
$1000
Updated
2021/12/16
Biosynth Carbosynth
Product number
FK159345
Product name
Kazinol B
Packaging
10mg
Price
$1500
Updated
2021/12/16
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kazinol B Chemical Properties,Usage,Production

Uses

Kazinol B, a prenylated flavan with a dimethyl pyrane ring, is an inhibitor of nitric oxide (NO) production. Kazinol B improves insulin sensitivity by enhancing glucose uptake via the insulin-Akt signaling pathway and AMPK activation. Kazinol B has the potential for diabetes mellitus research[1][2].

target

Calcium Channel | Sodium Channel | ATPase | NOS | PI3K | PKC | p38MAPK | PPAR | GLUT | Akt | AMPK

IC 50

AMPK

References

[1] Hyejin Lee, et al. Kazinol B from Broussonetia kazinoki improves insulin sensitivity via Akt and AMPK activation in 3T3-L1 adipocytes. Fitoterapia. 2016 Jul;112:90-6. DOI:10.1016/j.fitote.2016.05.006
[2] Jae-Ha Ryu, et al. Fitoterapia. 2003 Jun;74(4):350-4.Inhibition of nitric oxide production on LPS-activated macrophages by kazinol B from Broussonetia kazinoki. DOI:10.1016/s0367-326x(03)00062-5

kazinol B Preparation Products And Raw materials

Raw materials

Preparation Products

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  • kazinol B
  • Aids096026
  • Aids-096026
  • 6-[(2S)-7-hydroxy-3,4-dihydro-2H-chromen-2-yl]-2,2-dimethyl-7-(3-methylbut-2-enyl)chromen-8-ol
  • [2,6'-Bi-2H-1-benzopyran]-7,8'-diol, 3,4-dihydro-2',2'-dimethyl-7'-(3-methyl-2-buten-1-yl)-, (2S)-
  • 99624-27-8