6-Methylquinoline Property

Melting point:

-22°C

Boiling point:

256-260 °C (lit.)

Density 

1.067 g/mL at 20 °C (lit.)

vapor density 

>1 (vs air)

refractive index 

n20/D 1.614(lit.)

FEMA 

2744 | 6-METHYLQUINOLINE

Flash point:

>230 °F

storage temp. 

Store below +30°C.

solubility 

Chloroform (Slightly), Methanol (Slightly), soluble in alcohol and oils, and in Propylene glycol.

form 

Liquid

pka

5.21±0.10(Predicted)

color 

green-yellow

Specific Gravity

1.07

Odor

blossom odor, sweet, animalic upon dilution

Odor Type

animal

Water Solubility 

Not miscible or difficult to mix with water.

Sensitive 

Light Sensitive

JECFA Number

1302

BRN 

110336

LogP

2.54

CAS DataBase Reference

91-62-3(CAS DataBase Reference)

NIST Chemistry Reference

Quinoline, 6-methyl-(91-62-3)

EPA Substance Registry System

6-Methylquinoline (91-62-3)

Safety

Hazard Codes 

Xn

Risk Statements 

22-38-68-36/37/38

Safety Statements 

26-36-45-36/37/39

WGK Germany 

3

RTECS 

VC0550000

TSCA 

Yes

HS Code 

29334990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

6-Methylquinoline Chemical Properties,Usage,Production

Chemical Properties

6-Methylquinoline is a clear light yellow to light orange liquid that has a pungent, heavy odor. dissolved in 4 volumes of 50% ethanol or 60% ethanol of the same volume and in oily fragrances. May be synthesized from p-amino-benzaldehyde and acetone.

Occurrence

Reported found in Finnish and Japanese whiskey.

Application

6-Methylquinoline, is a building block used for the synthesis of various pharmaceutical compounds, and biologically active compounds. It can be used for the preparation of pyranobenzopyrone compounds, having anti-norovirus activity.

Uses

6-Methylquinoline can be used as primary carbon source in culture of Pseudomonas putida QP1. 6-Methylquinoline was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and fluorescent probes for determination of chloride in biological systems.

Definition

ChEBI: 6-methylquinoline is a member of quinolines.

General Description

Clear pale yellow liquid or oil with a quinoline odor.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

6-Methylquinoline is sensitive to prolonged exposure to light. May react vigorously with strong oxidizing agents and strong acids . Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Fire Hazard

6-Methylquinoline is probably combustible.

Biochem/physiol Actions

6-Methylquinoline undergoes biodegradation by quinoline-degrading culture of Pseudomonas putida.

Synthesis

6-Methylquinoline is obtain from coal tar, by synthesis from p-aminobenzaldehyde and acetone.

Purification Methods

Reflux it with BaO, then fractionally distil it. Further purified it via its recrystallised ZnCl2 complex (m 190o). [Cumper et al. J Chem Soc 1176 1962, Beilstein 20 III/IV 3498, 20/7 V 400.]