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Licofelone

Product Name
Licofelone
CAS No.
156897-06-2
Chemical Name
Licofelone
Synonyms
icofeL;ML 3000;Licofelone;Licofelone, >=99%;Licofelone, ML-3000;Licofelone USP/EP/BP;16-dihydrotanshinone I;2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid;1H-Pyrrolizine-5-aceticacid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-diMethyl-7-phenyl-;6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl- 1H-pyrrolizine-5-acetic Acid
CBNumber
CB91385206
Molecular Formula
C23H22ClNO2
Formula Weight
379.88
MOL File
156897-06-2.mol
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Licofelone Property

Melting point:
162-163°C
Boiling point:
539.7±50.0 °C(Predicted)
Density 
1.23
storage temp. 
-20°C Freezer
solubility 
Chloroform, Methanol
pka
4.47±0.10(Predicted)
form 
Solid
color 
Off-White to Light Yellow
CAS DataBase Reference
156897-06-2(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10007692
Product name
Licofelone
Purity
≥98%
Packaging
1mg
Price
$55
Updated
2024/03/01
Cayman Chemical
Product number
10007692
Product name
Licofelone
Purity
≥98%
Packaging
5mg
Price
$158
Updated
2024/03/01
Cayman Chemical
Product number
10007692
Product name
Licofelone
Purity
≥98%
Packaging
10mg
Price
$289
Updated
2024/03/01
Cayman Chemical
Product number
10007692
Product name
Licofelone
Purity
≥98%
Packaging
50mg
Price
$1305
Updated
2024/03/01
TRC
Product number
L397730
Product name
Licofelone
Packaging
1mg
Price
$50
Updated
2021/12/16
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Licofelone Chemical Properties,Usage,Production

Description

Cross-talk between lipoxygenase (LO) and cyclooxygenase (COX) pathways has been observed in human osteoarthritic synovial explants which creates an arachidonic acid shunting phenomenon, stimulating interleukin-1β (IL-1β) synthesis. Licofelone is a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LO) pathways, that decreases levels of prostaglandin E2, leukotriene B4, and lipoxins and prevents lipopolysaccharide-stimulated IL-1β expression. The IC50 values for inhibition of human thrombocyte COX and human 5-LO are 0.16 μM and 0.23 μM, respectively. Unlike other non-steroidal anti-inflammatory drugs, licofelone causes little or no damage to the gastric mucosa in rabbit parietal cells. This is presumably the result of licofelone’s affects on acid-secretory mechanisms, mediated by the inhibition of 5-LO activity.

Chemical Properties

Yellowish Solid

Uses

Dual inhibitor of cyclooxygenase and 5-lipoxygenase. Anti-inflammatory.

in vitro

the 5-lox and cox inhibitory effect of licofelone was firstly identified via bovine thromobocyte intact cell assay and intact bovine pmn leukocytes. licofelone was also reported to inhibit pge2 in a dose-dependent manner in human whole blood assay. moreover, licofelone was found to suppress in vitro generation of reactive oxygen species and to reduce release of elastase from pmn leukocytes. all above findings revealed that licofelone had an inhibitory effect on cox-1/-2 and 5-lox. [1]

in vivo

the pharmacodynamic properties of licofelone were evaluated in various animal models and compared with those of commonly used nsaids. based on studies from a rat model of incisional pain, orally administration of licofelone had a longer duration of action and was more effective than indomethacin and zileuton. [1]

IC 50

inhibitor of cox-1, cox-2 and 5-lox with ic50 values of 0.16 m, 0.37 m and 0.23 m respectively in human.

References

[1]kulkarni sk and singh vp. licofelone-a novel analgesic and anti-inflammatory agent. curr top med chem. 2007; 7(3): 251-63.

Licofelone Preparation Products And Raw materials

Raw materials

Preparation Products

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Licofelone Suppliers

Canada 1 China 97 France 1 India 1 United Kingdom 2 United States 21 Global 123
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
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View Lastest Price from Licofelone manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Licofelone 156897-06-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
Licofelone 156897-06-2
Price
US $3.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1kg,5kg,50kg
Release date
2020-01-18

156897-06-2, LicofeloneRelated Search:

Dimethyl ether Dimethyl sulfoxide Dimethyl fumarate Dimethyl sulfide Crospovidone N,N-Dimethylformamide N-Vinyl-2-pyrrolidone Dacthal Polyvinylpyrrolidone ETHANE Dimethyl carbonate N-Methyl-2-pyrrolidone Dimethyl sulfate Pyrrolidine Sodium L-pyroglutamate METHYL-2-PYRROLIDONE 1-METHYL-PYRROLE-2-ACETIC ACID 2,5-DIMETHYL-1-PROPYL-1H-PYRROLE

  • 2-[6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
  • Licofelone, ML-3000
  • [2,2-Dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
  • ML 3000
  • 2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid
  • Licofelone
  • 6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl- 1H-pyrrolizine-5-acetic Acid
  • 1H-Pyrrolizine-5-aceticacid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-diMethyl-7-phenyl-
  • Licofelone, >=99%
  • icofeL
  • Licofelone USP/EP/BP
  • 16-dihydrotanshinone I
  • 156897-06-2
  • C23H22ClNO2
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Inhibitors