Licofelone

ChemicalBook > CAS DataBase List > Licofelone

Product Name: Licofelone
CAS No.: 156897-06-2
Chemical Name: Licofelone
Synonyms: icofeL;ML 3000;Licofelone;Licofelone, >=99%;Licofelone, ML-3000;Licofelone USP/EP/BP;16-dihydrotanshinone I;2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid;1H-Pyrrolizine-5-aceticacid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-diMethyl-7-phenyl-;6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl- 1H-pyrrolizine-5-acetic Acid
CBNumber: CB91385206
Molecular Formula: C23H22ClNO2
Formula Weight: 379.88
MOL File: 156897-06-2.mol

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Licofelone Property

Melting point:: 162-163°C
Boiling point:: 539.7±50.0 °C(Predicted)
Density: 1.23
storage temp.: -20°C Freezer
solubility: Chloroform, Methanol
pka: 4.47±0.10(Predicted)
form: Solid
color: Off-White to Light Yellow
CAS DataBase Reference: 156897-06-2(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10007692
Product name: Licofelone
Purity: ≥98%
Packaging: 1mg
Price: $55
Updated: 2024/03/01

Cayman Chemical

Product number: 10007692
Product name: Licofelone
Purity: ≥98%
Packaging: 5mg
Price: $158
Updated: 2024/03/01

Cayman Chemical

Product number: 10007692
Product name: Licofelone
Purity: ≥98%
Packaging: 10mg
Price: $289
Updated: 2024/03/01

Cayman Chemical

Product number: 10007692
Product name: Licofelone
Purity: ≥98%
Packaging: 50mg
Price: $1305
Updated: 2024/03/01

TRC

Product number: L397730
Product name: Licofelone
Packaging: 1mg
Price: $50
Updated: 2021/12/16

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Licofelone Chemical Properties,Usage,Production

Description

Cross-talk between lipoxygenase (LO) and cyclooxygenase (COX) pathways has been observed in human osteoarthritic synovial explants which creates an arachidonic acid shunting phenomenon, stimulating interleukin-1β (IL-1β) synthesis. Licofelone is a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LO) pathways, that decreases levels of prostaglandin E₂, leukotriene B₄, and lipoxins and prevents lipopolysaccharide-stimulated IL-1β expression. The IC₅₀ values for inhibition of human thrombocyte COX and human 5-LO are 0.16 μM and 0.23 μM, respectively. Unlike other non-steroidal anti-inflammatory drugs, licofelone causes little or no damage to the gastric mucosa in rabbit parietal cells. This is presumably the result of licofelone’s affects on acid-secretory mechanisms, mediated by the inhibition of 5-LO activity.

Chemical Properties

Yellowish Solid

Uses

Dual inhibitor of cyclooxygenase and 5-lipoxygenase. Anti-inflammatory.

in vitro

the 5-lox and cox inhibitory effect of licofelone was firstly identified via bovine thromobocyte intact cell assay and intact bovine pmn leukocytes. licofelone was also reported to inhibit pge2 in a dose-dependent manner in human whole blood assay. moreover, licofelone was found to suppress in vitro generation of reactive oxygen species and to reduce release of elastase from pmn leukocytes. all above findings revealed that licofelone had an inhibitory effect on cox-1/-2 and 5-lox. [1]

in vivo

the pharmacodynamic properties of licofelone were evaluated in various animal models and compared with those of commonly used nsaids. based on studies from a rat model of incisional pain, orally administration of licofelone had a longer duration of action and was more effective than indomethacin and zileuton. [1]

IC 50

inhibitor of cox-1, cox-2 and 5-lox with ic50 values of 0.16 m, 0.37 m and 0.23 m respectively in human.

References

[1]kulkarni sk and singh vp. licofelone-a novel analgesic and anti-inflammatory agent. curr top med chem. 2007; 7(3): 251-63.

Licofelone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Licofelone manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Licofelone 156897-06-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: Licofelone 156897-06-2
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1kg,5kg,50kg
Release date: 2020-01-18

156897-06-2, LicofeloneRelated Search:

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2-[6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid

Licofelone, ML-3000

[2,2-Dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid

ML 3000

2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid

Licofelone

6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl- 1H-pyrrolizine-5-acetic Acid

1H-Pyrrolizine-5-aceticacid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-diMethyl-7-phenyl-

Licofelone, >=99%

icofeL

Licofelone USP/EP/BP

16-dihydrotanshinone I

156897-06-2

C23H22ClNO2

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