5,6-dihydro-1H-pyridin-2-one
- Product Name
- 5,6-dihydro-1H-pyridin-2-one
- CAS No.
- 6052-73-9
- Chemical Name
- 5,6-dihydro-1H-pyridin-2-one
- Synonyms
- 3,4-Dehydro-2-piperidone;5,6-Dihydro-2(1H)-pyridone;1,5,6-trihydropyridin-2-one;2,3-dihydro-1H-pyridin-6-one;5,6-dihdyro-1H-pyridin-2-one;5,6-Dihydro-2(1H)-pyridinone;5,6-dihydro-1H-pyridin-2-one;5,6-Dihydropyridin-2(1H)-one;2(1H)-Pyridinone, 5,6-dihydro-;1,2,5,6-tetrahydropyridin-2-one
- CBNumber
- CB91454850
- Molecular Formula
- C5H7NO
- Formula Weight
- 97.12
- MOL File
- 6052-73-9.mol
5,6-dihydro-1H-pyridin-2-one Property
- Melting point:
- 187-188℃
- Boiling point:
- 287.0±23.0 °C(Predicted)
- Density
- 1.052±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- Solid
- pka
- 15.07±0.20(Predicted)
- color
- Light brown to gray
- InChI
- InChI=1S/C5H7NO/c7-5-3-1-2-4-6-5/h1,3H,2,4H2,(H,6,7)
- InChIKey
- OXRRHYRRQWIHIV-UHFFFAOYSA-N
- SMILES
- C1(=O)NCCC=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D446515
- Product name
- 5,6-Dihydro-2(1H)-pyridinone
- Packaging
- 100mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- FD21959
- Product name
- 5,6-Dihydropyridin-2(1H)-one
- Packaging
- 10mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FD21959
- Product name
- 5,6-Dihydropyridin-2(1H)-one
- Packaging
- 25mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FD21959
- Product name
- 5,6-Dihydropyridin-2(1H)-one
- Packaging
- 50mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FD21959
- Product name
- 5,6-Dihydropyridin-2(1H)-one
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
5,6-dihydro-1H-pyridin-2-one Chemical Properties,Usage,Production
Uses
A new pyridone alkaloid as an intermediate in the synthesis of Piperlongumine (P482850).
Synthesis
1415686-28-0
6052-73-9
The general procedure for the synthesis of 5,6-dihydro-2(1H)-pyridinone from the compound (CAS:1415686-28-0) was as follows: intermediate 1 (41.6 g, 0.33 mol) was dissolved in 416 ml of anhydrous toluene, and the second-generation Grubbs catalyst (0.7 g) was added under stirring. The reaction mixture was heated to 85?90 °C and the reaction was continuously stirred for 7 hours. The reaction progress was monitored by gas chromatography (GC) and after confirming the completion of the reaction, the reaction mixture was cooled to room temperature. Subsequently, 8.5 ml of ammonia was added and stirring was continued for 1 hour. The reaction mixture was washed with water (3 x 30 ml) and the organic phase was dried with anhydrous Na2SO4. After filtration to remove the desiccant, the filtrate was concentrated to dryness under reduced pressure. To the concentrate, 300 ml of isopropyl ether was added and refluxed for 20 min, then cooled to -5?0 °C and allowed to stand for 6 h. The solid was collected by filtration. The solid was collected by filtration and washed with appropriate amount of isopropyl ether to give 24 g of intermediate 2 (white powdery solid) in 75% yield.
References
[1] Patent: CN106432189, 2017, A. Location in patent: Paragraph 0011; 0020
[2] European Journal of Medicinal Chemistry, 2012, vol. 57, p. 344 - 361
[3] European Journal of Medicinal Chemistry, 2016, vol. 107, p. 233 - 244
[4] European Journal of Medicinal Chemistry, 2017, vol. 125, p. 453 - 463
[5] Chemistry of Heterocyclic Compounds, 2016, vol. 52, # 3, p. 183 - 191
5,6-dihydro-1H-pyridin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5,6-dihydro-1H-pyridin-2-one manufacturers
- Product
- 5,6-dihydro-1H-pyridin-2-one 6052-73-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-21