ChemicalBook > CAS DataBase List > 2,4-dichloro-5-ethylpyrimidine
2,4-dichloro-5-ethylpyrimidine
- Product Name
- 2,4-dichloro-5-ethylpyrimidine
- CAS No.
- 34171-40-9
- Chemical Name
- 2,4-dichloro-5-ethylpyrimidine
- Synonyms
- 2,4-dichloro-5-ethylpyrimidine;2,4-Dichloro-5-ethyl-1,3-diazine;PyriMidine, 2,4-dichloro-5-ethyl-;2,4-Dichloro-5-ethylpyrimidine 97%
- CBNumber
- CB91464459
- Molecular Formula
- C6H6Cl2N2
- Formula Weight
- 177.03
- MOL File
- 34171-40-9.mol
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2,4-dichloro-5-ethylpyrimidine Property
- Boiling point:
- 246℃
- Density
- 1.335
- Flash point:
- 126℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.50±0.29(Predicted)
- Appearance
- White to off-white Solid
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P309+P311IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
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N-Bromosuccinimide Price
TRC
- Product number
- D436615
- Product name
- 2,4-Dichloro-5-ethylpyrimidine
- Packaging
- 10mg
- Price
- $70
- Updated
- 2021/12/16
TRC
- Product number
- D436615
- Product name
- 2,4-Dichloro-5-ethylpyrimidine
- Packaging
- 50mg
- Price
- $140
- Updated
- 2021/12/16
TRC
- Product number
- D436615
- Product name
- 2,4-Dichloro-5-ethylpyrimidine
- Packaging
- 1g
- Price
- $525
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR43523
- Product name
- 2,4-Dichloro-5-ethylpyrimidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $138
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0360884
- Product name
- 2,4-DICHLORO-5-ETHYLPYRIMIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.61
- Updated
- 2021/12/16
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2,4-dichloro-5-ethylpyrimidine Chemical Properties,Usage,Production
Uses
2,4-Dichloro-5-ethylpyrimidine is a reactant used for the synthesis of pyrimidine derivatives as inhibitors of dipeptidyl peptidase IV, TBK1/IKKε kinases, and as an inhibitor of a hedgehog signaling pathway.
Synthesis
4212-49-1
34171-40-9
Step A: Synthesis of 2,4-dichloro-5-ethylpyrimidine. To a mixture of 5-ethyluracil (1 g, 7.1 mmol) suspended in POCl3 (4.5 mL) was slowly added N,N-dimethylaniline (1 mL). The reaction mixture was heated under reflux conditions (~120°C) for 5 hours until the feedstock was completely dissolved and the solution took on a purple color. Once the reaction was complete, the mixture was allowed to cool to room temperature and slowly poured into ice (~40 g). The resulting precipitate was filtered and washed with ice water. The precipitate was dissolved in a minimal amount of dichloromethane (DCM) and purified by passing through a short silica gel column and separated by column chromatography using DCM as eluent to afford the target product, 2,4-dichloro-5-ethylpyrimidine (1.2 g, about 100% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ8.42 (s, 1H), 2.75 (q, 2H, J=7.6 Hz), 1.29 (t, 3H, J=7.6 Hz).
References
[1] Patent: EP1464335, 2004, A2. Location in patent: Page/Page column 329
[2] Nucleosides and Nucleotides, 1994, vol. 13, # 1-3, p. 235 - 243
[3] Patent: WO2004/41821, 2004, A1. Location in patent: Page 26-27
[4] Synthetic Communications, 1992, vol. 22, # 20, p. 2927 - 2934
[5] Collection of Czechoslovak Chemical Communications, 2006, vol. 71, # 4, p. 579 - 594
2,4-dichloro-5-ethylpyrimidine Preparation Products And Raw materials
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View Lastest Price from 2,4-dichloro-5-ethylpyrimidine manufacturers
Hebei Zhuanglai Chemical Trading Co Ltd
- Product
- 2,4-dichloro-5-ethylpyrimidine 34171-40-9
- Price
- US $100.00-50.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-11-12
Shaanxi Dideu Medichem Co. Ltd
- Product
- 2,4-Dichloro-5-ethylpyriMidine 34171-40-9
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-08-09
Shaanxi Dideu Medichem Co. Ltd
- Product
- 2,4-Dichloro-5-Ethylpyrimidine 34171-40-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15
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