(R)-1-BOC-3-HYDROXYMETHYLPIPERIDINE ETHYL ESTER
- Product Name
- (R)-1-BOC-3-HYDROXYMETHYLPIPERIDINE ETHYL ESTER
- CAS No.
- 194726-40-4
- Chemical Name
- (R)-1-BOC-3-HYDROXYMETHYLPIPERIDINE ETHYL ESTER
- Synonyms
- Ethyl (R)-1-Boc-nipecotate;Ethyl 1-Boc-D-nipecotate, 95%;Ethyl N-Boc-D-nipecotate, 95%;(R)-1-Boc-nipecotic Acid Ethyl Ester;Ethyl (R)-1-Boc-3-piperidinecarboxylate;Ethyl (R)-N-Boc-piperidine-3-carboxylate;[R]-1-BOC-Ethyl piperidine-3-carboxylate;[S]-1-BOC-Ethyl piperidine-3-carboxylate;Ethyl (R)-1-Boc-piperidine-3-carboxylate;(R)-ETHYL N-BOC-PIPERIDINE-3-CARBOXYLATE
- CBNumber
- CB91471002
- Molecular Formula
- C13H23NO4
- Formula Weight
- 257.33
- MOL File
- 194726-40-4.mol
(R)-1-BOC-3-HYDROXYMETHYLPIPERIDINE ETHYL ESTER Property
- Melting point:
- 35.0 to 39.0 °C
- Boiling point:
- 323.9±35.0 °C(Predicted)
- Density
- 1.077
- Flash point:
- >110℃
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- form
- powder to lump to clear liquid
- pka
- -2.40±0.40(Predicted)
- color
- White or Colorless to Almost white or Almost colorless
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36/37
- WGK Germany
- 3
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 696412
- Product name
- Ethyl (R)-N-Boc-piperidine-3-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $135
- Updated
- 2023/01/07
- Product number
- E0948
- Product name
- Ethyl (R)-1-(tert-Butoxycarbonyl)-3-piperidinecarboxylate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $151
- Updated
- 2025/07/31
- Product number
- 41510
- Product name
- Ethyl(R)-N-Boc-piperidine-3-carboxylate,95%
- Purity
- 95%
- Packaging
- 1G
- Price
- $107.52
- Updated
- 2021/12/16
- Product number
- 4H58-1-R16
- Product name
- (R)-1-Boc-ethyl piperidine-3-carboxylate
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 4H58-1-R16
- Product name
- (R)-1-Boc-ethyl piperidine-3-carboxylate
- Packaging
- 5G
- Price
- $320
- Updated
- 2021/12/16
(R)-1-BOC-3-HYDROXYMETHYLPIPERIDINE ETHYL ESTER Chemical Properties,Usage,Production
Synthesis
75-03-6
163438-09-3
194726-40-4
Under mechanical stirring, (R)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (1 kg, 4.36 mol) was dissolved in N,N-dimethylacetamide (3 L), followed by addition of potassium carbonate (0.664 kg, 4.80 mol). The resulting suspension was stirred at room temperature for 30 min. Ethyl iodide (0.75 kg, 4.80 mol) was slowly added through the addition funnel and stirring was continued at room temperature for 15 min, followed by warming to 50 °C and stirring for 1 h. The reaction was carried out by thin layer chromatography (TLC). The reaction process was monitored by thin layer chromatography (TLC, unfolding agent ratio ethyl acetate:hexane=1:1). Upon completion of the reaction, the reaction mixture was cooled to room temperature and diluted with ethyl acetate (5 L). Insoluble material was removed by diafiltration and the wet filter cake was washed with ethyl acetate (5L). The filtrates were combined and mixed with 5% w/v sodium thiosulfate solution (15L) with stirring, and the organic phase was separated by layering. The aqueous phase was extracted once more with ethyl acetate (5L). All organic layers were combined, washed with water (5L) and dried with anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to give a semi-solid product, which solidified on standing to ethyl (R)-1-Boc-piperidine-3-dicarboxylate in a yield of 1.1 kg and 99.5%.
References
[1] Patent: WO2014/135931, 2014, A1. Location in patent: Page/Page column 10
[2] Patent: US9657021, 2017, B2. Location in patent: Page/Page column 8; 9
(R)-1-BOC-3-HYDROXYMETHYLPIPERIDINE ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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