ChemicalBook > CAS DataBase List > 2,4,7-TRICHLOROQUINAZOLINE

2,4,7-TRICHLOROQUINAZOLINE

Product Name
2,4,7-TRICHLOROQUINAZOLINE
CAS No.
6625-94-1
Chemical Name
2,4,7-TRICHLOROQUINAZOLINE
Synonyms
2,4,7-TRICHLOROQUINAZOLINE;Quinazoline, 2,4,7-trichloro-;2,4-Dichloro-7-chloroquinazoline;2,4,7-trichloroquinazoline - [T87191];2,4,7-Trichloroquinazoline, 80% tech grade
CBNumber
CB91502502
Molecular Formula
C8H3Cl3N2
Formula Weight
233.48
MOL File
6625-94-1.mol
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2,4,7-TRICHLOROQUINAZOLINE Property

Melting point:
127 °C
Boiling point:
309.1±24.0 °C(Predicted)
Density 
1.600±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-1.14±0.30(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
T774728
Product name
2,4,7-Trichloroquinazoline
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
T774728
Product name
2,4,7-Trichloroquinazoline
Packaging
100mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
W7726
Product name
2,4,7-Trichloroquinazoline
Packaging
5g
Price
$289
Updated
2021/12/16
Matrix Scientific
Product number
188767
Product name
2,4,7-Trichloroquinazoline
Packaging
5g
Price
$676
Updated
2021/12/16
Matrix Scientific
Product number
188767
Product name
2,4,7-Trichloroquinazoline
Packaging
10g
Price
$1080
Updated
2021/12/16
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2,4,7-TRICHLOROQUINAZOLINE Chemical Properties,Usage,Production

Synthesis

13165-35-0

6625-94-1

Step B: Preparation of 2,4,7-trichloroquinazoline. 7-Chloro-1H-quinazoline-2,4-dione (2.0 g, 10 mmol) was suspended in acetonitrile (ACN, 50 mL), followed by the addition of phosphorus oxychloride (POCl3, 5.0 mL, 55 mmol) and diisopropylethylamine (DIEA, 5.0 mL, 28 mmol). The reaction mixture was heated to reflux for 36 hours. Upon completion of the reaction, it was cooled to room temperature and concentrated under reduced pressure. The residue was carefully quenched with ice water and sodium bicarbonate solution. The resulting solid product was collected by filtration and dried. Finally, purification by column chromatography (eluent: ethyl acetate/hexane, 0:100 to 10:90) afforded the target compound 2,4,7-trichloroquinazoline (2.1 g, 89% yield). The mass spectrometry (MS) and nuclear magnetic resonance (NMR) data were consistent with those reported in the literature (Bioorganic and Medicinal Chemistry, 2003, 11, 2439-2444).1H NMR (400 MHz, DMSO-d6) δ: 8.32 (d, J = 8.7 Hz, 1H), 8.20 (d, J = 1.9 Hz, 1H), 7.93 (dd, J = 9.0, 2.1 Hz, 1H).

References

[1] Pharmaceutical Chemistry Journal, 1987, vol. 21, # 7, p. 478 - 483
[2] Khimiko-Farmatsevticheskii Zhurnal, 1987, vol. 21, # 7, p. 802 - 807
[3] Journal of Medicinal Chemistry, 2008, vol. 51, # 24, p. 7855 - 7865
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 15, p. 7268 - 7274
[5] Patent: US2010/204226, 2010, A1. Location in patent: Page/Page column 22

2,4,7-TRICHLOROQUINAZOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4,7-TRICHLOROQUINAZOLINE Suppliers

China 114 Germany 1 India 1 United States 11 Global 127
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View Lastest Price from 2,4,7-TRICHLOROQUINAZOLINE manufacturers

Career Henan Chemical Co
Product
2,4,7-Trichloroquinazoline 6625-94-1
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-09

6625-94-1, 2,4,7-TRICHLOROQUINAZOLINERelated Search:

4,7-Dichloroquinazoline 2,4,7-TRICHLOROQUINAZOLINE

  • 2,4,7-TRICHLOROQUINAZOLINE
  • 2,4-Dichloro-7-chloroquinazoline
  • Quinazoline, 2,4,7-trichloro-
  • 2,4,7-Trichloroquinazoline, 80% tech grade
  • 2,4,7-trichloroquinazoline - [T87191]
  • 6625-94-1