2-Bromo-2-phenylacetic acid
- Product Name
- 2-Bromo-2-phenylacetic acid
- CAS No.
- 4870-65-9
- Chemical Name
- 2-Bromo-2-phenylacetic acid
- Synonyms
- A-BROMOPHENYLACETIC ACID;(S)-2-Bromo-2-Phenylacetic Acid;DL- NSC 59241;α-BromophenyL;TIMTEC-BB SBB007654;S-2--Bromo -2-phenyl;LABOTEST-BB LT00455397;Phenylbromoacetic acid;Bromo(phenyl)acetic acid;α-Bromophenylacetic acid
- CBNumber
- CB9154535
- Molecular Formula
- C8H7BrO2
- Formula Weight
- 215.04
- MOL File
- 4870-65-9.mol
2-Bromo-2-phenylacetic acid Property
- Melting point:
- 82-83 °C(lit.)
- Boiling point:
- 120-121 °C(Press: 0.02 Torr)
- Density
- 1.643±0.06 g/cm3(Predicted)
- storage temp.
- Store below +30°C.
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- pK1: 2.21 (25°C)
- color
- White to Almost white
- CAS DataBase Reference
- 4870-65-9(CAS DataBase Reference)
- NIST Chemistry Reference
- «ALPHA»-bromophenylacetic acid(4870-65-9)
Safety
- Hazard Codes
- C
- Risk Statements
- 34-36/37
- Safety Statements
- 26-27-28-36/37/39-45
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29163900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B75859
- Product name
- α-Bromophenylacetic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $63.35
- Updated
- 2025/07/31
- Product number
- B75859
- Product name
- α-Bromophenylacetic acid
- Purity
- 98%
- Packaging
- 25g
- Price
- $345
- Updated
- 2025/07/31
- Product number
- B0984
- Product name
- alpha-Bromophenylacetic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $35
- Updated
- 2025/07/31
- Product number
- B0984
- Product name
- alpha-Bromophenylacetic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $95
- Updated
- 2025/07/31
- Product number
- B695755
- Product name
- 2-Bromo-2-phenylaceticacid
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
2-Bromo-2-phenylacetic acid Chemical Properties,Usage,Production
Chemical Properties
Beige crystalline powder
Uses
α-Bromophenylacetic acid can be used as a reactant to prepare:
- Polymandelide by reacting with triethylamine.
- α-Mercaptophenylacetic acid by treating with sodium hydrosulfide (NaSH·H2O).
- β-Lactams by reacting with imines in the presence of triphenylphosphine as a mediator.
Uses
2-Bromo-2-phenylacetic Acid can be used as an inhibitor of mammalian collagenase and elastase.
Synthesis
103-82-2
4870-65-9
General procedure for the synthesis of α-bromophenylacetic acid from phenylacetic acid: 2-phenylacetic acid (376 mg, 2.7 mmol), N-bromosuccinimide (540 mg, 3.05 mmol), and carbon tetrachloride (5.5 mL) were added to a dry two-necked flask fitted with a condensing unit. Azobisisobutyronitrile (23 mg, 0.14 mmol) was added with stirring and the reaction was heated to reflux at 77°C with stirring for 2 hours. The progress of the reaction was monitored by nuclear magnetic resonance spectroscopy (1H NMR) until 2-phenylacetic acid was completely consumed. Upon completion of the reaction, the reaction was cooled naturally to room temperature, and the reaction mixture was diluted with hexane (10.0 mL) and filtered. The solvent was removed by rotary evaporation and purified by silica gel column chromatography (eluent: n-hexane/ether, 2:1, v/v) to afford α-bromophenylacetic acid as a white solid (95% yield).
References
[1] Patent: CN105384703, 2016, A. Location in patent: Paragraph 0014
[2] Journal of Organic Chemistry, 2016, vol. 81, # 20, p. 9620 - 9629
[3] Journal of Medicinal Chemistry, 1999, vol. 42, # 1, p. 50 - 59
[4] Journal of Medicinal Chemistry, 2003, vol. 46, # 20, p. 4333 - 4341
[5] Tetrahedron Letters, 2004, vol. 45, # 26, p. 5151 - 5154
2-Bromo-2-phenylacetic acid Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-Bromo-2-phenylacetic acid manufacturers
- Product
- 2-Bromo-2-phenylacetic acid 4870-65-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-11-11
- Product
- 2-Bromo-2-phenylacetic acid 4870-65-9
- Price
- US $30.00-20.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000KG
- Release date
- 2024-08-06
- Product
- 2-Bromo-2-phenylacetic acid 4870-65-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100
- Release date
- 2019-06-28